Protein Alignment Dcr-2 and dhx58

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: XP_002939087.3
• Gene: dhx58 / 100492559
• XenbaseID: XB-GENE-992480
• Length: 682
• Species: Xenopus tropicalis
• Alignment Length: 742
• Identity: 153/742 - (20%)
• Similarity: 261/742 - (35%)
• Gaps: 264/742 - (35%)

  Fly    11 YQLRLV-DHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGGKRALFMCNTVELARQQ- 73
            ||..:: ..|...|.|::||||:|||..|:.|..|..:     ::...|.| |:.|.|.|..|.
 Frog     6 YQWEVIAPALEGKNIIIWLPTGAGKTRAALYVAMRHLE-----MKRNAKVA-FIVNKVHLVDQHF 64

  Fly    74 -------------AMAVRRCTNFKVGFYVGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVT- 124
                         .:|:...|..|..|               :.:.:.|.|::.|||:..:.::
 Frog    65 SNEFQPHLKDKYTVVAISGDTEHKCFF---------------AQKTQDNDVIICTAQILQNALSS 114

  Fly   125 ---QTYVALSSLSVVIIDECHHGTGHHPFREFMRLF---TIANQTKLPRVVGLTGVLIKGNEITN 183
               :.:|.|:..:::|||||||......:.:.|..:   .|..:.|||:::|||     .:..|.
 Frog   115 GSEEMHVELTDFTLLIIDECHHTHKDGVYNKLMEGYLERKICRKGKLPQILGLT-----ASPGTG 174

  Fly   184 VATKLKELEITYRGNIITVSDTKEMENVMLYATKPTEVMVSFPHQEQVLTVTRLISAEIEKFYVS 248
            .||                |..|.:|:::.....              |...|::|||:.:
 Frog   175 RAT----------------SFHKAVEHILQICAN--------------LDTWRIMSAEVHR---- 205

  Fly   249 LDLMNIGVQPIRRSKSL-QCLRDP---------------------SKKSFVKQLFNDFLYQMKEY 291
            .||.....||.::...: |..|||                     |:..|..|::...:.::::.
 Frog   206 EDLEAKAKQPNKQYDLVAQRTRDPFGDKLKELMKTIHGYLRTAEFSESEFGTQVYEQKVVELEKE 270

  Fly   292 GI----------------YAASIAI---------ISLIVEFDIK----RRQ---AETLSVKLMHR 324
            |.                |..|:.:         ..|:.||.:.    |:|   .:|..::|..|
 Frog   271 GAVEADRMKRTCALHLRKYNDSLLVHDTVRMTDAYELLAEFYVTEKFIRKQNDPTDTFLIQLFDR 335

  Fly   325 TALTLCEKIRHLLVQKLQDMTYDDDDDNVNTEEVIMNFSTPKVQRFLMSLKVSFADKDPKDICCL 389
            ...||.|            :.:|.            .|..||:.:....||..|.......  .:
 Frog   336 NQATLLE------------LAHDS------------RFENPKLTKLEEILKDQFQFSSVSR--GI 374

  Fly   390 VFVERRYTCKCIYGLLLNYIQSTPELRNVLT-------------PQFMVGRNNISPDFESVLERK 441
            :|...|              |||..|.|.::             |....|.:|.|..    :.:.
 Frog   375 IFTRTR--------------QSTHSLHNWISGKDYFQKMGIKTAPLTGAGYSNQSKH----MTQN 421

  Fly   442 WQKSAIQQFRDGNANLMICSSVLEEGIDVQACNHVFILDPVKTFNMYVQSKGRARTTEA--KFVL 504
            .|:..|::||.|..||::.:||.|||:|:..||.|.....:......||::||||..::  .|:.
 Frog   422 EQREVIEKFRKGELNLLVSTSVAEEGLDIPQCNVVVRYGLMTNEIAMVQARGRARHEDSCYSFLA 486

  Fly   505 FTADKE--REKTIQQIYQYRKAHNDIAEYLKDRVLEKTE--PELYEIKGHFQDDIDPFTNENGAV 565
            .:..||  ||:|           |:|.|.|..|.::..:  ||     ..:::.|.....|
 Frog   487 KSGGKEIRREQT-----------NEILEDLMKRAIKHVQEMPE-----QEYEEKIKELQKE---- 531

  Fly   566 LLPNNALAILHRYCQTIPTDAFGFVIPWFHVLQEDERDRIF----------GVS----------- 609
                   :::.|..:.:               :.||:...|          |.|
 Frog   532 -------SLIARKVKQV---------------KRDEKRNTFYPEQVRFYCRGCSQAVAHGDDFRT 574

  Fly   610 AKGKHVISINMPVNCMLRDTIYSDPMD 636
            .:|.|.|:||........  :||.|::
 Frog   575 IEGTHYININPDFRIYYE--VYSPPIE 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	51/214 (24%)
		Dicer_PBD	241..343	CDD:277191	26/155 (17%)
		SF2_C_dicer	360..506	CDD:350189	40/160 (25%)
		Dicer_dimer	571..670	CDD:460900	14/87 (16%)
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333
		RIBOc	1448..1649	CDD:238333
		dsrm	1653..1717	CDD:425434
dhx58	XP_002939087.3	MPH1	1..>533	CDD:440728	139/657 (21%)
		DEXHc_RLR-3	1..201	CDD:350833	56/250 (22%)
		RLR_C_like	555..666	CDD:472430	10/47 (21%)