Protein Alignment Dcr-2 and ifih1

DIOPT Version :10

• Sequence 1: NP_523778.2
• Gene: Dcr-2 / 36993
• FlyBaseID: FBgn0034246
• Length: 1722
• Species: Drosophila melanogaster
• Sequence 2: XP_031749133.1
• Gene: ifih1 / 100488298
• XenbaseID: XB-GENE-1011111
• Length: 999
• Species: Xenopus tropicalis
• Alignment Length: 801
• Identity: 180/801 - (22%)
• Similarity: 315/801 - (39%)
• Gaps: 203/801 - (25%)

  Fly     5 EIKPRGYQLRLV-DHLTKSNGIVYLPTGSGKTFVAILVLKRFSQDFDKPIESGG-KRALFMCNTV 67
            :|..|.||:.:. ..|...|.|:.||||||||.||:.:.:   :...|..|.|. .:|:.:.|.|
 Frog   295 QITLRNYQMEVAKPALEGKNIIICLPTGSGKTRVAVYITR---EHLCKRREEGRLAKAIVLVNKV 356

  Fly    68 ELARQQAMAVRRCTNFKVGFY--------VGEQGVDDWTRGMWSDEIKKNQVLVGTAQVFLDMVT 124
            .|..|         :::..||        |.:...|...:..:...::::.|::.|||:..:.:.
 Frog   357 PLVEQ---------HYRREFYPFLKDHYQVTKISGDSQLKNSFHKVVQEHDVVICTAQILENSLI 412

  Fly   125 QTY------VALSSLSVVIIDECHHGTGHHPFREFM------RLFTIAN------QTKLPRVVGL 171
            |..      |.||..|::|||||||......:...|      ::....|      |..||:::||
 Frog   413 QAAEDEEEGVQLSDFSLIIIDECHHTQKDAVYNNIMIRYIKKKMQNKRNSKMEKAQVPLPQILGL 477

  Fly   172 T---GV----LIKGNE--ITNVATKLKELEI-TYRGNI-------------ITVSDTKEMENVML 213
            |   ||    .||.:|  |..:...:...:| |.:.|.             :.:||.|:...
 Frog   478 TASPGVGGAKNIKKSEEHILRICANMDAFKIMTVQENAEQLRKQVKDPYKEVKISDEKKKNP--- 539

  Fly   214 YATKPTEVMVSFPHQEQVLTVTRLISAEIEKFYVSLDLMNIGVQPIRRSKSLQCLRDPSKKSFVK 278
            :..|..|:|.......::...:...|...|::.:..|  ....:..:|.:.: |.....|.:...
 Frog   540 FGDKLKEIMGKIEEYSKLYPTSDHGSQSYEQWVIQTD--KTAAKEGKRKEHV-CAEHLRKYNDAL 601

  Fly   279 QLFNDFLYQMKEYGIYAASIAIISLIVEFDIKRRQAETLSVKLMHRTALTLCEKIRHLLVQKLQD 343
            |: ||.: :|.:        ::|.|...::.::::...|:....|...|.:.|..|.|:     |
 Frog   602 QI-NDTI-RMTD--------SLIHLRKFYEEEKKRKILLNEGSEHVAPLNIEETDRFLI-----D 651

  Fly   344 MTYDDDDDNVNTEEVIMNFSTPKVQ-RFLMSLKVSFADKDPKD--ICCLVFVERRYTCKCIYGLL 405
            :.||      |.:|:......||.: ..|.:|:.|..::..::  ...::|.:.|.:     .:.
 Frog   652 LFYD------NEKELTAIAKNPKYENENLYALRSSLLEEFTRNGQARGIIFTKTRQS-----AVA 705

  Fly   406 LN-YIQSTPELRNV-LTPQFMVGRNNISPDFESVLERKWQKSAIQQFRDGNANLMICSSVLEEGI 468
            || :|....:...| :...:::|..:.| ||:.:.:.: ||..|.:|..|..||::.:||.|||:
 Frog   706 LNQWISDNEKFTEVGIRSSYLIGAGHNS-DFKPMTQNE-QKQIIHKFSTGELNLLVATSVAEEGL 768

  Fly   469 DVQACNHVFILDPVKTFNMYVQSKGRARTTEAKFVLFTADK----EREKTIQQIYQYRKAHNDIA 529
            |::.||.|.....|......||::||||..::.:||.....    ||:..  .:|:....|..||
 Frog   769 DIKECNVVIRYGLVTNEIAMVQARGRARADDSSYVLVAPSSSGAIERDSV--NVYKEEMMHKAIA 831

  Fly   530 EYLK-DRVLEKTEPELYEIKGHFQDDIDPFTNENGAVLLPNNALA--ILHRYCQTIPTDAFGFVI 591
            :..| ||..             :.|.|:.|   ....::.....|  .:|:..|:.|:      :
 Frog   832 KVQKMDRAT-------------YIDKIEEF---QAQTIMEKKVKAKKAIHKVYQSNPS------L 874

  Fly   592 PWFHVLQEDERDRIFGVSAKGKHVISINMPVNCMLRDTIYSDPMDNVKTAKISAAFKACKVLYSL 656
            ..|| .::..:....|...:   ||:....||               .|.|.       |.|||.
 Frog   875 VTFH-CKKCSKQACCGTDIQ---VIATAHHVN---------------TTPKF-------KTLYSK 913

  Fly   657 GELNERFVPKTLKERVASIADVHFEHWNKYGDSV---------TATVNKA--------------- 697
            |.      .|||:|:        |..:...||.:         |..|:|.
 Frog   914 GP------NKTLQEK--------FADYQINGDIICKECGKTWGTTMVHKGIEVPCLQISKFVVKY 964

  Fly   698 -DK--SKDRTYK--TECPLEF 713
             ||  :|| ||.  :|.|::|
 Frog   965 DDKKMTKD-TYNKWSELPIKF 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-2	NP_523778.2	DEXHc_dicer	6..204	CDD:350792	62/248 (25%)
		Dicer_PBD	241..343	CDD:277191	17/101 (17%)
		SF2_C_dicer	360..506	CDD:350189	40/150 (27%)
		Dicer_dimer	571..670	CDD:460900	21/100 (21%)
		PAZ	843..1004	CDD:198017
		RIBOc	1194..1391	CDD:238333
		RIBOc	1448..1649	CDD:238333
		dsrm	1653..1717	CDD:425434
ifih1	XP_031749133.1	DD	8..95	CDD:472698
		CARD_2	108..199	CDD:465251
		MPH1	296..>836	CDD:440728	137/587 (23%)
		DEXHc_RLR-2	296..511	CDD:350832	60/226 (27%)
		MDA5_C	872..989	CDD:276945	34/160 (21%)