DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab4 and RAB11B

DIOPT Version :9

Sequence 1:	NP_523777.1	Gene:	Rab4 / 36992	FlyBaseID:	FBgn0016701	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_004209.2	Gene:	RAB11B / 9230	HGNCID:	9761	Length:	218	Species:	Homo sapiens

Alignment Length:	171	Identity:	90/171 - (52%)
Similarity:	114/171 - (66%)	Gaps:	4/171 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ETYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQ 67
            :.||||||.::||.:|.|||.||..|..::|..:|..||||||.:|.:.|.||::|.||||||||
Human     6 DEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQ 70

  Fly    68 ERFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVT 132
            ||:|::|.:|||||.|||||||.....::..:..||.:.|..|..||||:|||||.||...|.|.
Human    71 ERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVP 135

  Fly   133 FLEASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKI 173
            ..||..||::|.|.|:||||....||||||    |.||.:|
Human   136 TDEARAFAEKNNLSFIETSALDSTNVEEAF----KNILTEI 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	83/159 (52%)
RAB11B	NP_004209.2	Rab11_like	9..173	CDD:206660	89/168 (53%)
		Effector region. /evidence=ECO:0000255	40..48		5/7 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910