DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab4 and RAB2B

DIOPT Version :9

Sequence 1:	NP_523777.1	Gene:	Rab4 / 36992	FlyBaseID:	FBgn0016701	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_116235.2	Gene:	RAB2B / 84932	HGNCID:	20246	Length:	216	Species:	Homo sapiens

Alignment Length:	187	Identity:	113/187 - (60%)
Similarity:	138/187 - (73%)	Gaps:	0/187 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQE 68
            ||.||||::|||..|.||||||..|.:.:|:.....|||||||:|:||:.||.:|||||||||||
Human     2 TYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNIDGKQIKLQIWDTAGQE 66

  Fly    69 RFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVTF 133
            .|||:||||||||||||||||.|.|::||.||:||.|||..:|.|:||:|:|||.|||..|||..
Human    67 SFRSITRSYYRGAAGALLVYDITRRETFNHLTSWLEDARQHSSSNMVIMLIGNKSDLESRRDVKR 131

  Fly   134 LEASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYG 190
            .|...||:|:.|||:||||||..||||||:..:|.|..||:.|..|.....:||:.|
Human   132 EEGEAFAREHGLIFMETSAKTACNVEEAFINTAKEIYRKIQQGLFDVHNEANGIKIG 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	101/159 (64%)
RAB2B	NP_116235.2	PLN03108	1..216	CDD:178655	113/187 (60%)
		Effector region. /evidence=ECO:0000250	35..43		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..216		113/187 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910