Protein Alignment Rab4 and RAB6A

DIOPT Version :10

• Sequence 1: NP_523777.1
• Gene: Rab4 / 36992
• FlyBaseID: FBgn0016701
• Length: 213
• Species: Drosophila melanogaster
• Sequence 2: NP_002860.2
• Gene: RAB6A / 5870
• HGNCID: 9786
• Length: 208
• Species: Homo sapiens
• Alignment Length: 203
• Identity: 69/203 - (33%)
• Similarity: 120/203 - (59%)
• Gaps: 8/203 - (3%)

  Fly     9 FKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQERFRSV 73
            ||.:.:|....||:.|:..|:...|.:....|||::|.|:.:.:..::::||:|||||||||||:
Human    14 FKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSL 78

  Fly    74 TRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVTFLEAST 138
            ..||.|.:|.|::|||.|:.:||...|.|::|.||....:::|:|||||.||.:.|.|:..|...
Human    79 IPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGER 143

  Fly   139 FAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYGGAALRNLQTRQRS 203
            .|:|..::|:|||||.|.||::.|.:.:..:.....|.:...|.:        ..::..:.:::.
Human   144 KAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDM--------IDIKLEKPQEQP 200

  Fly   204 INKPDCTC 211
            :::..|:|
Human   201 VSEGGCSC 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	65/159 (41%)
RAB6A	NP_002860.2	Rab6	14..174	CDD:206654	65/159 (41%)
		Switch 1. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	32..50		5/17 (29%)
		Switch 2. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	69..88		12/18 (67%)