DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab4 and RAB2A

DIOPT Version :9

Sequence 1:	NP_523777.1	Gene:	Rab4 / 36992	FlyBaseID:	FBgn0016701	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_002856.1	Gene:	RAB2A / 5862	HGNCID:	9763	Length:	212	Species:	Homo sapiens

Alignment Length:	186	Identity:	109/186 - (58%)
Similarity:	135/186 - (72%)	Gaps:	0/186 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQER 69
            |.||||::|||..|.||||||..|.:.:|:.....|||||||:|::.:.||.:|||||||||||.
Human     3 YAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQES 67

  Fly    70 FRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVTFL 134
            |||:||||||||||||||||.|.||:||.||.||.|||..::.|:||:|:|||.|||..|:|...
Human    68 FRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKE 132

  Fly   135 EASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYG 190
            |...||:|:.|||:||||||..||||||:..:|.|..||:.|..|.....:||:.|
Human   133 EGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIG 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	98/159 (62%)
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	108/184 (59%)
		Required for interaction with PRKCI. /evidence=ECO:0000269\|PubMed:14570876	2..19		9/15 (60%)
		Effector region. /evidence=ECO:0000250	35..43		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910