Protein Alignment Rab4 and RAB25

DIOPT Version :10

• Sequence 1: NP_523777.1
• Gene: Rab4 / 36992
• FlyBaseID: FBgn0016701
• Length: 213
• Species: Drosophila melanogaster
• Sequence 2: NP_065120.2
• Gene: RAB25 / 57111
• HGNCID: 18238
• Length: 213
• Species: Homo sapiens
• Alignment Length: 171
• Identity: 85/171 - (49%)
• Similarity: 113/171 - (66%)
• Gaps: 0/171 - (0%)

  Fly     3 ETYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQ 67
            |.|:::||.::||.:|.||:.||..|..::|..||..||||||.:|.|.:|..:||.|||||||.
Human     7 EDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGL 71

  Fly    68 ERFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVT 132
            ||:|::|.:|||||.|||||:|.|...::..:..||.:....|...||::|||||.||.:||:|.
Human    72 ERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVP 136

  Fly   133 FLEASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKI 173
            ..||..||:.|.|:||||||....|||.||....|.|.||:
Human   137 TEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKV 177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	80/159 (50%)
RAB25	NP_065120.2	Rab11_like	11..174	CDD:206660	80/162 (49%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	35..49		7/13 (54%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	67..84		10/16 (63%)