Protein Alignment Rab4 and RAB39A

DIOPT Version :10

• Sequence 1: NP_523777.1
• Gene: Rab4 / 36992
• FlyBaseID: FBgn0016701
• Length: 213
• Species: Drosophila melanogaster
• Sequence 2: NP_059986.1
• Gene: RAB39A / 54734
• HGNCID: 16521
• Length: 217
• Species: Homo sapiens
• Alignment Length: 219
• Identity: 89/219 - (40%)
• Similarity: 131/219 - (59%)
• Gaps: 10/219 - (4%)

  Fly     1 MSETYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSS----HTIGVEFGSRIVNV-GGKSVKLQ 60
            |...:.|.|:.::||.:..|||||||.|.:.:|....|    .|:||:|.||::.: .||.:|||
Human     1 METIWIYQFRLIVIGDSTVGKSCLLHRFTQGRFPGLRSPACDPTVGVDFFSRLLEIEPGKRIKLQ 65

  Fly    61 IWDTAGQERFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASP-NIVILLVGNKKD 124
            :|||||||||||:||||||.:.|..||:|.|:|.||..:.:||.:|:....| .||.||||:|.|
Human    66 LWDTAGQERFRSITRSYYRNSVGGFLVFDITNRRSFEHVKDWLEEAKMYVQPFRIVFLLVGHKCD 130

  Fly   125 LEEARDVTFLEASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQY 189
            |...|.||..||...:.:..:.::|||||...||||:|...::.|...|:.||:..:....|::
Human   131 LASQRQVTREEAEKLSADCGMKYIETSAKDATNVEESFTILTRDIYELIKKGEICIQDGWEGVK- 194

  Fly   190 GGAALRNLQTRQRSINKP--DCTC 211
            .|.....:.:.:.:: ||  :|.|
Human   195 SGFVPNTVHSSEEAV-KPRKECFC 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	77/165 (47%)
RAB39A	NP_059986.1	Rab39	7..217	CDD:133311	87/211 (41%)
		Switch-I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	39..47		1/7 (14%)
		Switch-II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	71..87		13/15 (87%)