DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab4 and rab4a

DIOPT Version :9

Sequence 1:	NP_523777.1	Gene:	Rab4 / 36992	FlyBaseID:	FBgn0016701	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_001119853.1	Gene:	rab4a / 403031	ZFINID:	ZDB-GENE-040525-1	Length:	213	Species:	Danio rerio

Alignment Length:	215	Identity:	162/215 - (75%)
Similarity:	188/215 - (87%)	Gaps:	6/215 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSETYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTA 65
            ||||||:|||||:||:||:|||||||.|||.:|||||:|||||||||:|::|..|.|||||||||
Zfish     1 MSETYDFLFKFLVIGNAGTGKSCLLHQFIEKRFKDDSNHTIGVEFGSKIISVVNKFVKLQIWDTA 65

  Fly    66 GQERFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARD 130
            ||||||||||||||||||||||||.|||:::|||||||.|||.|||.||||:|.||||||:..|:
Zfish    66 GQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADRE 130

  Fly   131 VTFLEASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYGGAALR 195
            |||||||.|||||||:||||||.|||||||||::|::.||.|||:|||||||:|||||||.||||
Zfish   131 VTFLEASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALR 195

  Fly   196 NLQTRQR----SINKPDCTC 211
            .|::.:|    ||.  :|.|
Zfish   196 QLRSPRRAQAESIQ--ECGC 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	126/159 (79%)
rab4a	NP_001119853.1	RAB	9..172	CDD:197555	128/162 (79%)
		Rab4	9..169	CDD:206696	126/159 (79%)
		Effector region. /evidence=ECO:0000250	37..45		6/7 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I1696
eggNOG	1	0.900	-	-		E2759_KOG0086
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2359
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1146851at2759
OrthoFinder	1	1.000	-	-		FOG0001311
OrthoInspector	1	1.000	-	-		otm26014
orthoMCL	1	0.900	-	-		OOG6_102241
Panther	1	1.100	-	-	O	PTHR47979
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1999
SonicParanoid	1	1.000	-	-		X808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860