Protein Alignment Rab4 and RAB19

DIOPT Version :10

• Sequence 1: NP_523777.1
• Gene: Rab4 / 36992
• FlyBaseID: FBgn0016701
• Length: 213
• Species: Drosophila melanogaster
• Sequence 2: NP_001008749.2
• Gene: RAB19 / 401409
• HGNCID: 19982
• Length: 217
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 87/217 - (40%)
• Similarity: 131/217 - (60%)
• Gaps: 19/217 - (8%)

  Fly     3 ETYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQ 67
            |.:|||||.::||.:..||:|::.||....:.:...:||||:|..|.:::.||.||:|:||||||
Human    12 ENFDYLFKIILIGDSNVGKTCVVQHFKSGVYTETQQNTIGVDFTVRSLDIDGKKVKMQVWDTAGQ 76

  Fly    68 ERFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVT 132
            ||||::|:||||.|..|::.||.|.|.:|.::.:|:::.....:.|:||:|:|||.||.|.|.|.
Human    77 ERFRTITQSYYRSAHAAIIAYDLTRRSTFESIPHWIHEIEKYGAANVVIMLIGNKCDLWEKRHVL 141

  Fly   133 FLEASTFAQENELI-FLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYGGAALRN 196
            |.:|.|.|::..|: .||||||..:|:||.|:..:|.::|:           .|...||.:||..
Human   142 FEDACTLAEKYGLLAVLETSAKESKNIEEVFVLMAKELIAR-----------NSLHLYGESALNG 195

  Fly   197 LQ-------TRQRSINKPDCTC 211
            |.       ..|....|..|||
Human   196 LPLDSSPVLMAQGPSEKTHCTC 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	71/160 (44%)
RAB19	NP_001008749.2	Rab19	15..179	CDD:133267	74/163 (45%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:Q9H0U4	39..54		4/14 (29%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:Q9H0U4	74..89		11/14 (79%)