DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POSH and SH3RF1

DIOPT Version :9

Sequence 1:	NP_523776.1	Gene:	POSH / 36990	FlyBaseID:	FBgn0040294	Length:	838	Species:	Drosophila melanogaster
Sequence 2:	NP_065921.2	Gene:	SH3RF1 / 57630	HGNCID:	17650	Length:	888	Species:	Homo sapiens

Alignment Length:	1014	Identity:	294/1014 - (28%)
Similarity:	428/1014 - (42%)	Gaps:	307/1014 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPP 65
            |||..|.|||||.|||||||.::||||||||||::||..||.|:::|||||||.||...::|||.
Human     1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPS 65

  Fly    66 NVLLMRILEGMKQNA-AAGKGEEKG-----------------EETETQPERAKPQPPAESVAPPD 112
            |:||:|:|:|:||.. ..|.|...|                 ...:.|..:...||..:|.:||.
Human    66 NILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPV 130

  Fly   113 NQLLQLQSHQQSHQPARHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQA 177
            ..:.|                   ||.|.||:::...|..||||.|||:|:::.::|.||:.|:.
Human   131 RGIPQ-------------------LPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEV 176

  Fly   178 NGQEGTFPINYVKVSVPLPM--PQCIAMYDFKMGPND-EEGCLEFKKSTVIQVMRRVDHNWAEGR 239
            ||..|.||.|:|::..|||.  |||.|:|||::...: ::.||.|.|..|:.|:||||.|||||.
Human   177 NGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGM 241

  Fly   240 IGQTIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGSSNS 304
            :...||||||::||.|:|||:|::..                 .||||.:|
Human   242 LADKIGIFPISYVEFNSAAKQLIEWD-----------------KPPVPGVD-------------- 275

  Fly   305 TPGSSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSASVRFRDKGAKEKRHSLNALLGGGAPLSL 369
               :...||.::.::.:|.|..:..||                    :||||..:|...... |.
Human   276 ---AGECSSAAAQSSTAPKHSDTKKNT--------------------KKRHSFTSLTMANKS-SQ 316

  Fly   370 LQTNRHSAEILSLP--------------HELSRLEVS-------SSTAL---KPTSAPQT----- 405
            ...||||.|| |.|              .|||.|..|       |:|.|   .|.|:|.|
Human   317 ASQNRHSMEI-SPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSF 380

  Fly   406 --------------------------SRVLKTT---------------------------VQQQM 417
                                      :.||.:|                           ::.|.
Human   381 TFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQT 445

  Fly   418 QPNLPWGYLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNW-LDITGVFPGNYLTPL--- 478
            :|::   |:|::||.||:.|||||:||.:::|.|||.||||||.:. ....|||||||:.|:
Human   446 RPSV---YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRA 507

  Fly   479 -----RARDQQQLMHQWK-----YVPQNADAQMAQVQQHPVA--PDVRLNNMLSMQPPDLPPR-- 529
                 :|:.......|..     ..|..|.....::|.:.||  |.|....::|.......|:
Human   508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAK 572

  Fly   530 -------------------------QQQATATTTSCSVWS----KPVEALFSRKSEPKPETATAS 565
                                     |::.||..|...|.:    .|.....|..|...|:.|...
Human   573 VLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLASPQPAPLM 637

  Fly   566 TTSSSSSGAVGLMRRLTHMKTRSKSP-------GASLQQVPKEAISTNVE-FTTNPSAKLHPVHV 622
            ..|::.:.|:.:.|....:...:.:|       .|||:..|...|.|.:. ..|:|.:
Human   638 PGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDS------- 695

  Fly   623 RSGSCPSQLQHSQPLNETPAAKTAAQQQQFLPKQLPSASTNSVSYGSQRVKGSKERPHLICARQS 687
            .|.:|.:.       :.|...|.:.::::.|.|.|..|||             |.:|.:
Human   696 ASSACGNS-------SATKPDKDSKKEKKGLLKLLSGAST-------------KRKPRV------ 734

  Fly   688 LDAATFRSMYNNAASPPPPTT--------------SVAPAVYAGGQQQ-----VIPGGGAQSQLH 733
                          |||...|              :|.|.:..||...     .:.|.|..:...
Human   735 --------------SPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAV 785

  Fly   734 ANMIIAPS--HRKSHSLDASHVLSPSSNMITEAAIKASATTKSPYCTRESRFRCIVPYPPNSDIE 796
            |...:|..  |||:.|||::..::|.......:.......::...|   .|.|.:|.|||.|:.|
Human   786 AGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVC---ERHRVVVSYPPQSEAE 847

  Fly   797 LELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVE 835
            |||..|||::|.:|:::||:|||..|..||||||.||||
Human   848 LELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RING	11..53	CDD:238093	29/41 (71%)
		SH3	139..191	CDD:302595	23/51 (45%)
		SH3_SH3RF_2	199..251	CDD:212721	27/52 (52%)
		SH3_SH3RF_3	424..477	CDD:212717	30/53 (57%)
		SH3_SH3RF_C	782..836	CDD:212719	32/54 (59%)
SH3RF1	NP_065921.2	RING	11..56	CDD:238093	31/44 (70%)
		SH3	137..190	CDD:302595	24/52 (46%)
		SH3_SH3RF1_2	200..254	CDD:212863	27/53 (51%)
		SH3_SH3RF1_3	449..503	CDD:212859	30/56 (54%)
		SH3_SH3RF_C	833..887	CDD:212719	32/54 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9642
eggNOG	1	0.900	-	-		E33208_3BCIE
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	382	1.000	Inparanoid score	I2058
Isobase	1	0.950	-	0	Normalized mean entropy	S4993
OMA	1	1.010	-	-		QHG47017
OrthoDB	1	1.010	-	-		D151303at33208
OrthoFinder	1	1.000	-	-		FOG0003366
OrthoInspector	1	1.000	-	-		otm42279
orthoMCL	1	0.900	-	-		OOG6_106609
Panther	1	1.100	-	-	O	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10491
SonicParanoid	1	1.000	-	-		X2254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820