Protein Alignment POSH and cindr

DIOPT Version :10

• Sequence 1: NP_523776.1
• Gene: POSH / 36990
• FlyBaseID: FBgn0040294
• Length: 838
• Species: Drosophila melanogaster
• Sequence 2: NP_001263129.1
• Gene: cindr / 43654
• FlyBaseID: FBgn0027598
• Length: 941
• Species: Drosophila melanogaster
• Alignment Length: 815
• Identity: 191/815 - (23%)
• Similarity: 278/815 - (34%)
• Gaps: 279/815 - (34%)

  Fly   144 FDFASGEATDLKFKKGDLILIKHRI---DNNWFVG--QANGQEGTFPINYVKV------------ 191
            :::|:.|..:|..:||.:|   |||   ...|:.|  :|:|..|.||.|:|:|
  Fly    11 YEYAAKEPDELDLQKGAII---HRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVSSNGNGT 72

  Fly   192 -----------SVPL------PMPQCIAMYDFKMGPNDEEGCLEFKKSTVIQVMRRVDHNWAEGR 239
                       :|.|      ...:|..:|.:.. .||:|  |......||:.:..|:..|..||
  Fly    73 TGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQ-VNDDE--LTLAVGDVIEFLGEVEEGWWRGR 134

  Fly   240 IGQTIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTES-SSGSSN 303
            :...:|:||..||:             |..|   .|....:|.    |.|..||.|.: :|.::|
  Fly   135 LRSKVGVFPSNFVQ-------------HIEP---SPVLASKRP----PTIGATVTTSALTSKAAN 179

  Fly   304 --------------STPGSSNSSSTSSSNNCSPNH-----QISLPNTPQHVVASGSASVRFRDKG 349
                          :.|.:|.|.|||::...:.:.     ..|.|..|..:| |||
  Fly   180 VANVAATATVPTGGAVPPASTSISTSTTKQATKSRATAAAAASAPAEPAAIV-SGS--------- 234

  Fly   350 AKEKRHSLNALLGGGAPLSLLQTNRHSAEILSLP----HELSRLEVSSSTALKPTSAPQTSRVLK 410
                    .|..||||          :|.:..||    .|..|:|
  Fly   235 --------GAAAGGGA----------AAAVPMLPPKPQREFCRVE-------------------- 261

  Fly   411 TTVQQQMQPNLPWGYLALFPYKPRQTDELELKKGCVYIV--TERCVDGWFKGKNWLDI---TGVF 470
                              |||.|:..||||||...:..|  ||....||:||    :|   .|||
  Fly   262 ------------------FPYAPQNDDELELKVDDIIAVISTELPDKGWWKG----EIRGKVGVF 304

  Fly   471 PGNYLTPLRARDQQQLMHQWKYVPQNADAQMAQVQQHPVAPDVRLNNMLSMQPPDLP-------- 527
            |.|::..|              .|..|.|.       |..|..|        |...|
  Fly   305 PDNFVKML--------------APSEATAA-------PPLPRPR--------PRTRPGMGGTGAG 340

  Fly   528 -----------PRQQQ------------ATATTTSCSVWSKPVEALFSRKSEPKPETATASTTS- 568
                       ||:.|            |:..||..:..::|..|....:::.|... ||||||
  Fly   341 SGSGIIDGVRTPRRTQRGGSFEFLGARMASFITTIFAPINEPPSATQITQNQRKVSN-TASTTSH 404

  Fly   569 -----SSSSGAVGLMRRLTHMKTRSKSPGASLQQVPKEAISTNVEFTTNPSAKLHPVHVRSGSCP 628
                 ||:|....:..:....:....|...|...:.|...|:|  .||:.:........|..|..
  Fly   405 MTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYIKKTGSSSN--STTSSTTTASSSAGRKESFG 467

  Fly   629 SQLQHSQPLNET--PAAKTAAQQQQFLPKQL----PSASTNSVSYGSQRVKGSKERPH--LICAR 685
            |:...:..|:||  |....|||::....|.|    |.....|||.|.||...|.....  ...|.
  Fly   468 SRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTKPPGVGASVSIGQQRSSTSSATTSSATTVAT 532

  Fly   686 QSLDAATFRSMYN----NAASPPPPTTSVAPAV-----YAGGQQQVIPG-----GGAQSQLHANM 736
            ....::..:||.|    ...|||||..|..|:|     ..||    :|.     ||.:......:
  Fly   533 GLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPLKKTPTGG----VPMTGNLLGGKKKNTEGKL 593

  Fly   737 IIAPSHRKSHSLDASHVLS-----PSSNMITEAAIKASAT-----------TKSPYCT--RESRF 783
            ..|.||..:..|.||.:||     |.|.......|:.:||           .::...|  |:.|.
  Fly   594 TTAVSHDLADGLAASKMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRV 658

  Fly   784 RCIVPYPPNSDIELELHLGD----IIYVQRKQKNG 814
            :.....||::.|.:   ||:    .:||.....:|
  Fly   659 KAPKRRPPSAAINV---LGESNNNSVYVNGSGMSG 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RAD18	6..>113	CDD:227719
		RING-HC_SH3RF3	8..53	CDD:438408
		SH3	139..191	CDD:473055	18/51 (35%)
		SH3_SH3RF_2	199..251	CDD:212721	15/51 (29%)
		SH3_SH3RF_3	424..477	CDD:212717	23/57 (40%)
		SH3_SH3RF_C	782..836	CDD:212719	9/37 (24%)
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	18/51 (35%)
		SH3_CD2AP-like_2	97..149	CDD:212807	17/67 (25%)
		SH3_CD2AP-like_3	258..310	CDD:212808	25/93 (27%)