Protein Alignment POSH and EndoB

DIOPT Version :10

• Sequence 1: NP_523776.1
• Gene: POSH / 36990
• FlyBaseID: FBgn0040294
• Length: 838
• Species: Drosophila melanogaster
• Sequence 2: NP_611410.1
• Gene: EndoB / 37218
• FlyBaseID: FBgn0034433
• Length: 390
• Species: Drosophila melanogaster
• Alignment Length: 304
• Identity: 73/304 - (24%)
• Similarity: 111/304 - (36%)
• Gaps: 74/304 - (24%)

  Fly    78 QNAAAGKGEEKGEETETQPERAKPQPPAESVAPPDNQLLQLQSHQ-QSHQPARHKQRRFLLPHAY 141
            ||.|     |:.:.|:|..|:......:..:..|.|::......: :..:|.|......|   |.
  Fly    45 QNLA-----ERADVTKTWTEKIVRDTESVLIPNPQNRVEDFIFEKIEKSKPKRLSNLEHL---AL 101

  Fly   142 ALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVS---VPLPMPQCIAM 203
            .:.:.......||.:.:.   |||        ||||..:.|....:::..|   ...|:.:.:
  Fly   102 DMIEAGGDFGQDLPYGQA---LIK--------VGQAEQKLGQCEHDFIATSGICFTQPLRKFL-- 153

  Fly   204 YDFKMGP-NDEEGCLEFKKSTVIQVMRRVDHNWAEGRIGQTI--GIFPIAFVE------------ 253
             |.:|.. ..|.|.||.|:..:.....||..  |...:||..  ||.|.|.:|
  Fly   154 -DGEMKTIGKERGILETKRLDLDACKNRVKK--ARSMLGQQSKDGISPEAVLEQAERDLRVAQAE 215

  Fly   254 --LNAAAKKLLDSGL---------HTHPF----------CHPPKQQGQRALP----PVPVIDPTV 293
              ..|...|||..|:         |.|.|          |....:|.||.|.    |.|.| |..
  Fly   216 FDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQRELANLGGPTPYI-PLD 279

  Fly   294 VTESSSGSSNSTPGSS--NSSSTSSSNNCSPNHQISLPNTPQHV 335
            |.|:|:..||.:.|::  ...:..|:|..:..|:   ||.|.||
  Fly   280 VNEASASKSNISSGAAARGPGNNHSANMAATGHK---PNQPMHV 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RAD18	6..>113	CDD:227719	8/34 (24%)
		RING-HC_SH3RF3	8..53	CDD:438408
		SH3	139..191	CDD:473055	11/51 (22%)
		SH3_SH3RF_2	199..251	CDD:212721	15/54 (28%)
		SH3_SH3RF_3	424..477	CDD:212717
		SH3_SH3RF_C	782..836	CDD:212719
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	54/244 (22%)
		SH3_Endophilin_B	327..378	CDD:212736