DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POSH and sorb-1

DIOPT Version :9

Sequence 1:	NP_523776.1	Gene:	POSH / 36990	FlyBaseID:	FBgn0040294	Length:	838	Species:	Drosophila melanogaster
Sequence 2:	NP_001360603.1	Gene:	sorb-1 / 3565590	WormBaseID:	WBGene00012891	Length:	1007	Species:	Caenorhabditis elegans

Alignment Length:	449	Identity:	109/449 - (24%)
Similarity:	181/449 - (40%)	Gaps:	103/449 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RILEGMKQNAAAGKGEEKGEETETQPERAKPQPPAESVAPP-DNQLLQLQS-----HQQSHQPAR 129
            |:.:..::.....|.|:..||...:.||.....|  |.||. .|.:.:|.|     .....:||.
Worm   615 RVKQSNEEELLRLKAEKLAEELRKEKERKHSFIP--SSAPSLQNNMDRLNSLLYDFSSDIQEPAH 677

  Fly   130 HKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVSV- 193
            .......:..|.|::.|....|.:|...:||:|.|...:|..|..|:.||:.|.||.:||:::.
Worm   678 RDYTPQPVMTATAVYKFEPRSARELPLNRGDIIRIIREVDGYWMEGERNGRSGIFPTSYVQINTG 742

  Fly   194 -PLPMPQCIAMYDFKMGPNDEEGCLEFKKSTVIQVMRRVDHNWAEG--RIGQTIGIFPIAFVELN 255
             .....:..|:|.|....:.|   |..|:..:|...|::|.||.||  :|| .:||||.::||
Worm   743 NQGDSQKMRAIYPFTARSDTE---LSLKRGEIITRRRQIDSNWLEGSNQIG-IVGIFPASYVE-- 801

  Fly   256 AAAKKLLDSGLHTHPFCHPPKQQGQRALPPV-------PVID-----------PTVVTESSSG-- 300
                               |.:|.::.:|.:       |.|:           .||:.:|:.|
Worm   802 -------------------PIEQVEQHIPTIVPNRPKTPKIEDQVYNQVYKPNETVIMQSNQGYY 847

  Fly   301 -SSNSTPG--------SSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSASVRFRDKGAKEKRHS 356
             .:...|.        |.:.|:...|.:.:| ||...|  |.|...|......:   |.|:..:.
Worm   848 DKAAVVPNNKVRFDLPSGSDSNLQISRSLNP-HQNQFP--PTHTQTSTQQPSNY---GMKKIEYE 906

  Fly   357 LNALLGGGAPLSLLQTNRHSAEILSLPHELSRLEVSSSTALKPTSAPQTSRVLKTTVQQQMQPNL 421
            ...::....|:.:.|..:.:.|                    |.:..:.:.:|......     :
Worm   907 REKVVEEVPPMHMDQYRKLNDE--------------------PKNPKKDTNILMNAASL-----I 946

  Fly   422 PWG---YLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNWL--DITGVFPGNYL 475
            |.|   |.|::||:|::.|||:|....:..|.|:|.||||.|.:..  |. |:|||||:
Worm   947 PKGSEMYRAVYPYQPQKEDELQLYTNDIIFVVEKCDDGWFIGTSLRTGDF-GIFPGNYV 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RING	11..53	CDD:238093
		SH3	139..191	CDD:302595	19/51 (37%)
		SH3_SH3RF_2	199..251	CDD:212721	19/53 (36%)
		SH3_SH3RF_3	424..477	CDD:212717	25/57 (44%)
		SH3_SH3RF_C	782..836	CDD:212719
sorb-1	NP_001360603.1	Sorb	505..553	CDD:383053
		SH3_Sorbs_1	687..739	CDD:212715	19/51 (37%)
		SH3_Sorbs_1	749..802	CDD:212715	21/77 (27%)
		SH3_Sorbs_3	952..1006	CDD:212714	24/54 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910