DRSC/TRiP Functional Genomics Resources

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Protein Alignment POSH and SH3RF3

DIOPT Version :10

Sequence 1:NP_523776.1 Gene:POSH / 36990 FlyBaseID:FBgn0040294 Length:838 Species:Drosophila melanogaster
Sequence 2:NP_001092759.1 Gene:SH3RF3 / 344558 HGNCID:24699 Length:882 Species:Homo sapiens


Alignment Length:931 Identity:311/931 - (33%)
Similarity:450/931 - (48%) Gaps:192/931 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPP 65
            |||.:|.|||||||||||||||:|||||||||||:||:.||.|:|:||||||||||.|.:||||.
Human    46 MDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPA 110

  Fly    66 NVLLMRILEGMKQNAAAGKGEEKGEETETQPERAKP-QP-PAESVAP-------------PDN-- 113
            |:||:|:|:|::|...||          |.|..:.| :| |.:|.||             |.:  
Human   111 NILLVRLLDGIRQRPRAG----------TSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPV 165

  Fly   114 -----------QLLQLQSHQQSHQPARHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHR 167
                       .|.:|.:.:.:  ||  .:...|||:..||:.:...|..||||.|||:|:::.:
Human   166 FLSAAAGSTAGSLRELATSRTA--PA--AKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRK 226

  Fly   168 IDNNWFVGQANGQEGTFPINYVKVSVPLP--MPQCIAMYDFKMGPNDEE-GCLEFKKSTVIQVMR 229
            :|..|:.|:.:|.:|..|.:|::...|||  .||..|:|||:|...|:: .||.|.|..::.|:|
Human   227 VDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLR 291

  Fly   230 RVDHNWAEGRIGQTIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVV 294
            |||.|||||.:|..|||||:.:||||.:||:|::.   ..| |.........:||          
Human   292 RVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEM---DKP-CPAAASSCNASLP---------- 342

  Fly   295 TESSSGSSNS---TPGSSNSSSTSS-------SNNCSPNHQISLPNTPQHVVASGSASVRFRDKG 349
              |.||:..|   :|..|:|.:.|:       ..|....|..:            :.||..|...
Human   343 --SDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFT------------ALSVTHRSSQ 393

  Fly   350 AKEKRHSLNALLGGGAPLSLLQTN-RHSAEILSLPHELS----RLEVSSSTALKPTSAPQTSRVL 409
            |...|||:..    .||:.:..:: |.:|.|..|.| ||    ..:||||....||:.|:.:.| 
Human   394 AASHRHSMEI----SAPVLISSSDPRAAARIGDLAH-LSCAAPTQDVSSSAGSTPTAVPRAASV- 452

  Fly   410 KTTVQQQMQP--NLPWG-YLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNW-LDITGVF 470
              :.:|...|  .||.. ||||:.|||:::|||||.||.:|.|.|:|.||||||.:. ..::|||
Human   453 --SGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVF 515

  Fly   471 PGNYLTPLRARDQQQLMHQWKYVPQNAD-------------AQMAQVQQHPVAPDVRLNNMLSMQ 522
            ||||:||:            ..||....             |:......||.:..  |:::.:..
Human   516 PGNYVTPV------------SRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS--LSSLATAT 566

  Fly   523 PPDLPPRQQQATATTTSCSVWSKPVEALFSRKSEPKPETA--TASTTSSSSSGA----VGLMRRL 581
            .|.||....||.|...:.   |.|..:.....::|....|  |.||.:.|::.|    ...:..|
Human   567 RPALPITTPQAHAQHPTA---SPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPL 628

  Fly   582 THMKTRSKSPGASL----------------QQVPKEAIS-TNVEFTTNP----SAKLH------P 619
            ....:.|:.|..||                |..|:.||. |:......|    :|.|:      |
Human   629 RTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGP 693

  Fly   620 VHVRSGSCPSQLQHSQPLNETPAAKTAAQQQQFLPKQLPSASTNSVSYGSQRVKGSKERPHLICA 684
            :.|.|.|.|:..  ...|:|..:.|  .:::..|.|.|..|||...|.....|..:.: |.:   
Human   694 IGVLSTSSPTNT--GCKLDEKKSEK--KEKKSGLLKLLAGASTKKKSRSPPSVSPTHD-PQV--- 750

  Fly   685 RQSLDAATFRSMYNNAASPPPPTTSVAPAVYAGGQQQVIPGGGAQSQLHANMIIAPSHRKSHSLD 749
              ::||     :...|..|...:.|:      .|:....|   .:|::...|.:.|.|||:.|||
Human   751 --AVDA-----LLQGAVGPEVSSLSI------HGRAGSCP---IESEMQGAMGMEPLHRKAGSLD 799

  Fly   750 ASHVLSPSSNMITEAAIKASATTKSPYCTRESRFRCIVPYPPNSDIELELHLGDIIYVQRKQKNG 814
            .:.. |||    .:|.:..:|....|......|:|.:|.|||.|:.|:||..|||::|.:|:::|
Human   800 LNFT-SPS----RQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDG 859

  Fly   815 WYKGTHARTHKTGLFPASFVE 835
            |||||..|..:|||||.||||
Human   860 WYKGTLQRNGRTGLFPGSFVE 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POSHNP_523776.1 RAD18 6..>113 CDD:227719 66/121 (55%)
RING-HC_SH3RF3 8..53 CDD:438408 37/44 (84%)
SH3 139..191 CDD:473055 18/51 (35%)
SH3_SH3RF_2 199..251 CDD:212721 27/52 (52%)
SH3_SH3RF_3 424..477 CDD:212717 31/54 (57%)
SH3_SH3RF_C 782..836 CDD:212719 31/54 (57%)
SH3RF3NP_001092759.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..42
RING-HC_SH3RF3 53..98 CDD:438408 37/44 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..159 10/44 (23%)
SH3_SH3RF3_1 197..250 CDD:212861 19/52 (37%)
SH3_SH3RF3_2 260..314 CDD:212864 27/53 (51%)
DUF5585 338..731 CDD:465521 118/445 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..399 6/42 (14%)
Interaction with RAC1. /evidence=ECO:0000269|PubMed:20696164 369..439 21/86 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..458 9/27 (33%)
SH3_SH3RF3_3 467..523 CDD:212858 32/55 (58%)
PLN02217 <516..649 CDD:215130 32/149 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..664 19/91 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..747 16/57 (28%)
SH3_SH3RF_C 827..881 CDD:212719 31/54 (57%)
Blue background indicates that the domain is not in the aligned region.

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