DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment POSH and Sh3rf2

DIOPT Version :10

Sequence 1:NP_523776.1 Gene:POSH / 36990 FlyBaseID:FBgn0040294 Length:838 Species:Drosophila melanogaster
Sequence 2:NP_001139771.1 Gene:Sh3rf2 / 269016 MGIID:2444628 Length:735 Species:Mus musculus


Alignment Length:839 Identity:234/839 - (27%)
Similarity:341/839 - (40%) Gaps:228/839 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPP 65
            ||:.||.|||||.||.|:||.|:||||||||||:.|||.|..:..:|||||||.||.|.|:.||.
Mouse     1 MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAHKELRCPECRTLVFCSIEALPA 65

  Fly    66 NVLLMRILEGMKQNAAAGKGE--EKGEETETQPERAKPQPPAESVAPPDNQLLQLQSHQQSHQPA 128
            |:||:|:|:|::...::.||.  .:......|..|.....|....|.|...:..::.|...    
Mouse    66 NLLLVRLLDGVRSGQSSWKGGSFRRPRILTLQDNRKAKSSPRSLQASPFRLVPSVRIHMDG---- 126

  Fly   129 RHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKV-- 191
                    :|.|.||.::......||||.|||:||::.::|.||:.|:.||..|.||.:.|:|  
Mouse   127 --------VPRAKALCNYRGKNPGDLKFNKGDVILLRRQLDENWYQGEINGVSGIFPASSVEVIK 183

  Fly   192 SVPLPMPQCIAMYDFKMGPNDE---EGCLEFKKSTVIQVMRRVDHNWAEGRIGQTIGIFPIAFVE 253
            .:|.|.|.|.|:|:|.:...|:   :.||.|.|..||.|:.|||.|||||::|..:|||||.|||
Mouse   184 QLPQPPPLCRALYNFDLRDKDKSENQDCLTFLKDDVITVISRVDENWAEGKLGDKVGIFPILFVE 248

  Fly   254 LNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGSSNSTPGSSNSSS----- 313
            .|.:|:.||::..|          |..|......:..|:....:::.|...:|||....|     
Mouse   249 PNVSARHLLENKGH----------QLSRTRHLSLMSSPSRGKATNTSSLRKSPGSRRKGSGQFSM 303

  Fly   314 TSSSNNC-----SP-NHQISLPNTPQHVVASGSASVRFRDKGAKEKRHSLNALLGGGAPLSLLQT 372
            |::.|..     || .||:...:||. :::|.|.|| ....|.|           ...|.|    
Mouse   304 TTALNTLNRTVHSPEGHQMVEISTPM-LISSNSPSV-LTQHGDK-----------ADFPTS---- 351

  Fly   373 NRHSAEILSLPHELSRLEVSSSTALKPTSAPQTSRVLKTTVQQQMQPNLPWGYLALFPYKPRQTD 437
                          |..:||||.....:....|:.|...:.||.:..|:   ::||..|...:.:
Mouse   352 --------------STGQVSSSQPAPASPGHSTAMVSVPSSQQHLSNNM---FVALHTYSAHRPE 399

  Fly   438 ELELKKGCVYIVTERCVDGWFKGKNWL-DITGVFPGNYLTPL---RARDQQQLMHQWKYVPQNAD 498
            ||:|:||....|..:..|||.||.:.| ..||:||.:|:.|:   .||.....            
Mouse   400 ELDLQKGEGIRVLGKYQDGWLKGLSLLTGRTGIFPSDYVIPVFSSTARKTSSF------------ 452

  Fly   499 AQMAQVQQHPVAPDVRLNNMLSMQPPDLPPRQQQATATTTSCSVWSKPVEALFSRKSEPKPETAT 563
                        ||.|                     :.|.|:.|:                   
Mouse   453 ------------PDSR---------------------SPTVCTTWA------------------- 465

  Fly   564 ASTTSSSSSGAVGLMRRLTHMKTRSKSPGASLQQVPKEAISTNVEFTTNPSA-------KLHPVH 621
            .||:|.||.|:      ......|...|..|: .||...::.: ..|..|.:       |:....
Mouse   466 LSTSSVSSQGS------FAEGDPRQSGPFKSV-FVPTAVVNPS-RSTPGPGSSGQGSLRKVRSSM 522

  Fly   622 VRSGSCPSQLQHSQP------LNETPAAKTAAQQQQFLPKQ--LPSASTNSVSYGSQRV------ 672
            .::||....:|...|      |..:|......|:.||.|.|  .||.:...|..||:.:      
Mouse   523 RKNGSLQRPVQSGIPTFMVGSLRCSPTMVIRPQRFQFYPPQGMTPSPTPIMVEMGSKSIYTGEPA 587

  Fly   673 -----KGSKER------------------------------PHLICARQSLDAATFRSM----YN 698
                 :|||.|                              |.::...::....|.:.:    :.
Mouse   588 LTCINRGSKTRIHSAGNSIIMEGKETPIKSEPPPKPPASAPPSILVKPENSKNGTEKQVKTVRFQ 652

  Fly   699 NAASPPPPTTSVA---------PAVYAGGQQQVIPGGGAQSQLHANMIIAPSHRKS-HS 747
            | .||||...|.:         ||...|.|.:.:..||       .|.|..:||.. ||
Mouse   653 N-YSPPPTKHSASSPTSGKHDHPATLKGSQHEAVSSGG-------EMTILFAHRSGCHS 703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POSHNP_523776.1 RAD18 6..>113 CDD:227719 52/108 (48%)
RING-HC_SH3RF3 8..53 CDD:438408 30/44 (68%)
SH3 139..191 CDD:473055 22/51 (43%)
SH3_SH3RF_2 199..251 CDD:212721 26/54 (48%)
SH3_SH3RF_3 424..477 CDD:212717 20/53 (38%)
SH3_SH3RF_C 782..836 CDD:212719
Sh3rf2NP_001139771.1 RING-HC_SH3RF2 11..55 CDD:438407 29/43 (67%)
SH3_SH3RF2_1 128..181 CDD:212862 23/52 (44%)
SH3_SH3RF2_2 191..247 CDD:212865 26/55 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..302 9/49 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..378 15/74 (20%)
Interaction with PAK4. /evidence=ECO:0000250|UniProtKB:Q8TEC5 372..465 32/140 (23%)
SH3_SH3RF2_3 386..440 CDD:212718 20/56 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..534 5/37 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..720 20/100 (20%)
Interaction with PPP1CA. /evidence=ECO:0000250 647..652 0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

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