Protein Alignment POSH and SH3RF2

DIOPT Version :10

• Sequence 1: NP_523776.1
• Gene: POSH / 36990
• FlyBaseID: FBgn0040294
• Length: 838
• Species: Drosophila melanogaster
• Sequence 2: XP_011535869.1
• Gene: SH3RF2 / 153769
• HGNCID: 26299
• Length: 735
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 232/872 - (26%)
• Similarity: 356/872 - (40%)
• Gaps: 274/872 - (31%)

  Fly     1 MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPP 65
            ||:.||.|||||.||.|:||.|:||||||||||:.|||.:..:..:|||||||..|...|:.||.
Human     1 MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNIEALPA 65

  Fly    66 NVLLMRILEGMKQNAAAGKGE----------EKGEETETQPERAKPQPPAESVAPPDNQLLQLQS 120
            |:||:|:|:|::...::|:|.          :.|.::.|.|.|.:..|            .:|..
Human    66 NLLLVRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASP------------FRLVP 118

  Fly   121 HQQSHQPARHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFP 185
            :.:.|...        :|.|.||.::......||:|.|||:||::.::|.||:.|:.||..|.||
Human   119 NVRIHMDG--------VPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFP 175

  Fly   186 INYVKV--SVPLPMPQCIAMYDFKMGPNDE---EGCLEFKKSTVIQVMRRVDHNWAEGRIGQTIG 245
            .:.|:|  .:|.|.|.|.|:|:|.:...|:   :.||.|.|..:|.|:.|||.|||||::|..:|
Human   176 ASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVG 240

  Fly   246 IFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGSSNST---PG 307
            ||||.|||.|..|:.||:            |.:|:::.....:   ::|:.||.|::::.   ||
Human   241 IFPILFVEPNLTARHLLE------------KNKGRQSSRTKNL---SLVSSSSRGNTSTLRRGPG 290

  Fly   308 SSNS-----SSTSSSNNC-----SPN--HQISLPNTPQHVVASGSASVRFRDKGAKEKRHSLNAL 360
            |...     |.|::.|..     ||:  |.:.: :||. :::|.:.||..:   ..||....::.
Human   291 SRRKVPGQFSITTALNTLNRMVHSPSGRHMVEI-STPV-LISSSNPSVITQ---PMEKADVPSSC 350

  Fly   361 LG-----GGAPLSLLQTNRHSAEILSLPHELSRLEVSSSTALKPTSAPQTSRVLKTTVQQQMQPN 420
            :|     ..||:|    ..||..::|||..                            ||.:..|
Human   351 VGQVSTYHPAPVS----PGHSTAVVSLPGS----------------------------QQHLSAN 383

  Fly   421 LPWGYLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNWL-DITGVFPGNYLTPLRARDQQ 484
            :   ::||..|.....|||:|:||....|..:|.|||.:|.:.: ...|:||.||:.|:..:...
Human   384 M---FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445

  Fly   485 QLMHQWKYVPQNADAQMAQVQQHPVAPDVRLNNMLSMQPPDLPPRQQQATATTTSCSVWSKPVEA 549
                                     .||.|...:.:
Human   446 -------------------------FPDSRSPGLYT----------------------------- 456

  Fly   550 LFSRKSEPKPETATASTTSSSSSGAVGLMRRLTHMKTRSKSPGASLQQVPKEAISTNVEFTTNPS 614
                       |.|.||:|.||.|::              |.|...|..|.:::..       |:
Human   457 -----------TWTLSTSSVSSQGSI--------------SEGDPRQSRPFKSVFV-------PT 489

  Fly   615 AKLHPVH--------------------------VRSGSCPSQLQHSQP------LNETPAAKTAA 647
            |.::||.                          .|.||....||...|      |..:|......
Human   490 AIVNPVRSTAGPGTLGQGSLRKGRSSMRKSKWWQRDGSLQRPLQSGIPTLVVGSLRRSPTMVLRP 554

  Fly   648 QQQQFL-PKQLPSA-STNSVSYGSQRVKGSKERPHLICARQSLDAATFRSMYNNAASP------- 703
            ||.||. |:.:||: |...|..||:.....:  |.|.|..:..:|     ..::|||.
Human   555 QQFQFYQPQGIPSSPSAVVVEMGSKPALTGE--PALTCISRGSEA-----WIHSAASSLIMEDKE 612

  Fly   704 --------PPPTTSVAPAVYAGGQQQVIPGGGAQSQLHA----NMIIAPS-HRKSHSLDASHVLS 755
                    |.|..|..|::....:..   ..|.:.|:..    |....|: |..||
Human   613 IPIKSEPLPKPPASAPPSILVKPENS---RNGIEKQVKTVRFQNYSPPPTKHYTSH--------- 665

  Fly   756 PSSNMITE-AAIKAS---ATTKSPYCT 778
            |:|....: |.:|||   |.:..|..|
Human   666 PTSGKPEQPATLKASQPEAASLGPEMT 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RAD18	6..>113	CDD:227719	49/116 (42%)
		RING-HC_SH3RF3	8..53	CDD:438408	29/44 (66%)
		SH3	139..191	CDD:473055	21/51 (41%)
		SH3_SH3RF_2	199..251	CDD:212721	25/54 (46%)
		SH3_SH3RF_3	424..477	CDD:212717	20/53 (38%)
		SH3_SH3RF_C	782..836	CDD:212719
SH3RF2	XP_011535869.1	RING-HC_SH3RF2	11..55	CDD:438407	28/43 (65%)
		SH3_SH3RF2_1	128..181	CDD:212862	22/52 (42%)
		SH3_SH3RF2_2	191..247	CDD:212865	25/55 (45%)
		SH3_SH3RF2_3	384..438	CDD:212718	20/56 (36%)