DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POSH and sh3rf2

DIOPT Version :9

Sequence 1:	NP_523776.1	Gene:	POSH / 36990	FlyBaseID:	FBgn0040294	Length:	838	Species:	Drosophila melanogaster
Sequence 2:	XP_009289332.1	Gene:	sh3rf2 / 100537944	ZFINID:	ZDB-GENE-141212-301	Length:	769	Species:	Danio rerio

Alignment Length:	886	Identity:	231/886 - (26%)
Similarity:	363/886 - (40%)	Gaps:	174/886 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQ-HKLRCPECRILVSCKIDELP 64
            |::..:.:||||.:|:|.||.::||||||||||:.|||....|. .:|.|||||..|...::|||
Zfish     1 MEDLAVMELLECPLCMEPLDVSAKVLPCQHTFCKSCLQQQETSHPDQLCCPECRAAVPGSVEELP 65

  Fly    65 PNVLLMRILEGMKQNAAAGKGEEKGEETETQPERAKPQPPAESVAPPDNQLLQLQSHQQSHQPAR 129
            .|.||.|:||.:.:........::.....:.|            |..|:.....|...:..|..:
Zfish    66 TNPLLHRLLESLHEWGPVSTPRDRSVRYMSSP------------AQEDHCSSYTQDLPKQEQNTQ 118

  Fly   130 HKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKV--S 192
            ..|       |.||:||......:|..|.||:|.::.|:|:||:.|:.....|..|:|.::|  .
Zfish   119 RVQ-------AQALYDFQGNAPGELTMKSGDIIYLRWRVDDNWYYGEGKDSRGLVPVNVLQVLSE 176

  Fly   193 VPLPMPQCIAMYDFKMGPNDEEG---CLEFKKSTVIQVMRRVDHNWAEGRIGQTIGIFPIAFVEL 254
            .|.|:..|.|:|||.....|.||   ||.|.|...|.::::|:.||.||::|..:||||:...|.
Zfish   177 QPQPLALCRALYDFNANNLDPEGSKECLTFFKGDSITLLKQVNENWVEGKLGDKVGIFPLQLTEP 241

  Fly   255 NAAAKKLLDSGLHTHPFCHPPKQQGQRALP--PVPVIDPTVVTESSSGSSNSTPGSSNSSSTSSS 317
            |.||.:||:.        | .::....|.|  .|.|.....:....:|.|..:...||.:..:|.
Zfish   242 NPAAYELLEK--------H-KRRDSVEAQPRSSVRVNADACIHRRLTGPSQKSSRPSNVNLLNSL 297

  Fly   318 NNCSPNHQISLPNTPQHVVASGSAS-------VRFRDKGAKEKRHSL---NALLGGGAPLSLLQT 372
             ||.|   :||...|.|:.:|...|       ..|.....:..|.:|   :..:.|.:|.::
Zfish   298 -NCPP---LSLSQQPPHISSSAQPSYSKTPQLATFNRPRLRSSRRNLPKRHRTMNGESPPAI--- 355

  Fly   373 NRHSAEILSLPHELSRLEVSSSTALKPTSAPQTSRVLKTTVQQQMQPNLPWGYLALFPYKPRQTD 437
                                :...:.|.::|..|. .|.:..||:..::   ..||:.|.|.:::
Zfish   356 --------------------TMALINPQASPMPSE-SKMSATQQLSISV---CAALYSYTPYRSE 396

  Fly   438 ELELKKGCVYIVTERCVDGWFKGKNWLDI----TGVFPGNYLTPLRARDQQQLMHQWKYVPQNAD 498
            ||||:||.:..|..:..:||.:|   |.:    .|:.|.||:||: .|...:.:.|.|
Zfish   397 ELELRKGEMVGVYGKFSEGWLRG---LSLKTGKVGILPTNYVTPV-LRTSARFLEQSK------- 450

  Fly   499 AQMAQVQQHPVAPDVRLNNMLSMQPPDLPPRQQQATATTTSCSVWSKP--VEALFSRKSEPKPET 561
                                     |.:|    .::|.:|......||  |.....|.:...| :
Zfish   451 -------------------------PAIP----NSSAVSTKRHASHKPQAVVLALDRVNTDSP-S 485

  Fly   562 ATASTTSSSSSGAVGLM-----------------RRLTHMKTRSKSPGASLQQVPKEAISTNVEF 609
            ||...|||:..|....:                 |.|.|..:.:.:...|||..|:: :.....|
Zfish   486 ATMPVTSSAGPGRAAQLGGKQGWSSVRRSFHATHRGLPHHGSYNSNSILSLQPPPQD-LGQIYTF 549

  Fly   610 TTNPSAKLHPVHVRSG--SCPSQLQHSQPLNETPAAKTAAQQQQFLPKQLPSAST-NSVSYGSQR 671
            ..:|...    ..|:|  |.|.:.||.  ..||.:....|.|....|.|..:.:| .|:......
Zfish   550 GRSPVLP----KKRNGLFSNPMKAQHW--AYETTSPSAGAYQPIINPGQKETTTTRQSILVKPDA 608

  Fly   672 VKGSKERPHLICARQSLDAATFRSMYNNAASPPPPTTSVAPAVYAGGQQQVIPGGGAQSQLHANM 736
            .|.:.|:|        :.:..|.:......:|..|:||.     ||......||.......:.:.
Zfish   609 YKNNAEKP--------VKSVRFLAHDTPQTAPKTPSTST-----AGLSSSSQPGFSTLDHWNPSA 660

  Fly   737 IIAPSHRKSHSLDASHVLSPSSNMIT---EAAIKASATTKSPYC----TRESRFRCIVPYPPNSD 794
            |:.   |..|:|......:|.:...|   .||:.:.|....|..    :..||.|.|..|...:|
Zfish   661 ILG---RDGHTLVLKDTKTPPARKSTGQDHAAMDSLALNMKPVLINNQSGSSRCRVIKGYNAKTD 722

  Fly   795 IELELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVE 835
            .||.|..|:::.|||.:.:|....|...:.|||||.:|.:|
Zfish   723 AELTLTEGEMVLVQRPRADGRVLVTQEISGKTGLFQSSVLE 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RING	11..53	CDD:238093	24/42 (57%)
		SH3	139..191	CDD:302595	18/51 (35%)
		SH3_SH3RF_2	199..251	CDD:212721	23/54 (43%)
		SH3_SH3RF_3	424..477	CDD:212717	19/56 (34%)
		SH3_SH3RF_C	782..836	CDD:212719	21/54 (39%)
sh3rf2	XP_009289332.1	RING_Ubox	8..54	CDD:327409	26/45 (58%)
		SH3	122..173	CDD:327375	18/50 (36%)
		SH3	183..237	CDD:327375	23/53 (43%)
		SH3	384..437	CDD:327375	19/55 (35%)
		SH3	710..763	CDD:327375	20/52 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151303at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920