DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment POSH and sh3rf3

DIOPT Version :9

Sequence 1:	NP_523776.1	Gene:	POSH / 36990	FlyBaseID:	FBgn0040294	Length:	838	Species:	Drosophila melanogaster
Sequence 2:	XP_002937706.2	Gene:	sh3rf3 / 100490093	XenbaseID:	XB-GENE-6045188	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	919	Identity:	298/919 - (32%)
Similarity:	435/919 - (47%)	Gaps:	174/919 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPP 65
            |||.:|.||||||||||||||:::||||||||||:||..||:|:::||||||||||.|.:|:||.
Frog    45 MDESSLLDLLECSVCLERLDTSARVLPCQHTFCRRCLHSIVSSRNELRCPECRILVECGVDDLPA 109

  Fly    66 NVLLMRILEGMKQNAAAGKGEEKGEETETQPERAKPQ---------PPAESVAPPDN-----QLL 116
            |:||:|:|:|::|..   :|...|..|.|....:...         .|..|.|...|     .|.
Frog   110 NILLVRLLDGIRQRP---RGSPTGSPTATGQHGSSNNSNNHSSNCGSPGCSAAHTANASCTSSLR 171

  Fly   117 QL-QSHQQSHQPARHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQ 180
            .| .:.|.:...|::..:   ||...||:.:...|..||||.|||:|:::.::|.||:.|:.||.
Frog   172 DLATASQNALMLAKNISQ---LPCGRALYAYEGKEPGDLKFNKGDIIILRRKVDENWYHGELNGN 233

  Fly   181 EGTFPINYVKVSVPL--PMPQCIAMYDFKMGPNDEE-GCLEFKKSTVIQVMRRVDHNWAEGRIGQ 242
            .|.||.:||:...||  |.||..|:|||::...|:: .||.|.|..::.|:||||.|||||.:|.
Frog   234 RGFFPASYVQCIKPLTQPPPQGKALYDFEIKDKDQDKDCLTFTKDEILTVIRRVDDNWAEGMLGD 298

  Fly   243 TIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGSSNSTPG 307
            .||||||.:||||..||:|::.                         |...:|   :......|.
Frog   299 KIGIFPILYVELNETAKQLIEK-------------------------DKMCLT---AAQGYEVPV 335

  Fly   308 SSNSSSTSSSNNCSPNHQISLPNTPQ-HVVASGSASVRFRD-KGAKEKRHSLNALLGGGAPLSLL 370
            |.::|..           :|:..:|. :...:|||:.|..| |...:||||..| |......|..
Frog   336 SFDASML-----------VSVTQSPTLNSAGAGSANQRHIDIKRNTKKRHSFTA-LSMTHKSSHA 388

  Fly   371 QTNRHSAEI-------LSLPHELSRL----EVSSSTALKPTSA-----------PQTSRVL---K 410
            ..||||.||       .|.|...:|:    ::|||...:.:||           |:|..|:   .
Frog   389 MNNRHSMEISAPVLISSSDPRAAARIGELTQLSSSAPAQDSSAFGSSSVAGAAGPKTGTVIGEQG 453

  Fly   411 TTVQQQMQPNLPWGYLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNW-LDITGVFPGNY 474
            |:.:.|:..|:   ||||:.|||::.|||||:||.:|.|.|:|.||||||.:. ...:|||||||
Frog   454 TSPKIQLPLNI---YLALYAYKPQKNDELELRKGEMYRVIEKCQDGWFKGTSLRTGQSGVFPGNY 515

  Fly   475 LTPLRARDQQQLMHQWKYVPQNADAQMAQVQQ-HPVAPDVRLNNMLSMQPPDLPPRQQQATATTT 538
            :||: :|....|:|     .:|.....:...: .|:|                   ...:|..||
Frog   516 VTPV-SRVPAGLVH-----ARNCTMGASHTTRGSPLA-------------------VHTSTGGTT 555

  Fly   539 SCSVWSKPVEALFSRKSEPKPETATASTTSSSSSGAVGLMRRLTHMKTR-SKSPGASLQQVPKEA 602
            :|:...:|:..:...:..|......:|....|:........::.|...: .:.|.|::..:..::
Frog   556 NCTNVVRPILPITVPQLHPHQSPTNSSNMKISAQHQARSTIQMGHSSAQPQERPTATVSPLRTQS 620

  Fly   603 ISTNVEFTTNPSAKL-HPVHVRSGSCPSQLQHSQ----PLNETPAAKTAAQQQQFLPKQLPSAST 662
            ..:.:....|.:..: .|.|::....||...|..    ||....||.|        |..:.:|:.
Frog   621 SPSRLPANLNRTHSIVSPQHIQQSGLPSPPIHCARPVIPLTSAAAAIT--------PPNVSAANL 677

  Fly   663 N--------SVSYGSQRVKGSKERPHLICARQS----LDAATFRSMYNNAASPPPPTTSVAPAVY 715
            |        |:..||....|.:........|:.    |......|....:.|||..:.:..|.|.
Frog   678 NGEAANGPISLLTGSPTNTGCRTDERKTEKREKKSGLLKLLVGASAKKKSRSPPSISPTHDPQVV 742

  Fly   716 AGGQQQVIPG---------GGA-----QSQLHANMIIAPSHRKSHSLD-----ASHVLSPSSNMI 761
            ..|..|...|         |.|     :|::...|.:.|.|||:.|||     .|.|..|.|.||
Frog   743 VEGMIQGAVGLELSSMNSHGRAGSCPLESEMQGAMGMHPLHRKTGSLDLNFSFPSPVRQPVSAMI 807

  Fly   762 TEAAIKASATTKSPYCTRESRFRCIVPYPPNSDIELELHLGDIIYVQRKQKNGWYKGTHARTHKT 826
                    |....|......|:|.:|||||.|:.|:||..|||::|.:|:::||||||..|..:|
Frog   808 --------AVRPEPKTLFRERYRVVVPYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRT 864

  Fly   827 GLFPASFVE 835
            ||||.||||
Frog   865 GLFPGSFVE 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RING	11..53	CDD:238093	31/41 (76%)
		SH3	139..191	CDD:302595	22/51 (43%)
		SH3_SH3RF_2	199..251	CDD:212721	27/52 (52%)
		SH3_SH3RF_3	424..477	CDD:212717	31/53 (58%)
		SH3_SH3RF_C	782..836	CDD:212719	32/54 (59%)
sh3rf3	XP_002937706.2	RING-HC_SH3RF3	52..97	CDD:319664	34/44 (77%)
		SH3_SH3RF3_1	191..244	CDD:212861	23/52 (44%)
		SH3_SH3RF3_2	254..308	CDD:212864	27/53 (51%)
		SH3_SH3RF3_3	463..519	CDD:212858	33/58 (57%)
		SH3_SH3RF_C	820..874	CDD:212719	32/54 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8617
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2062
OMA	1	1.010	-	-		QHG47017
OrthoDB	1	1.010	-	-		D151303at33208
OrthoFinder	1	1.000	-	-		FOG0003366
OrthoInspector	1	1.000	-	-		otm49510
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10491
SonicParanoid	1	1.000	-	-		X2254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110