Protein Alignment Ns2 and NUG1

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_010921.1
• Gene: NUG1 / 856723
• SGDID: S000000808
• Length: 520
• Species: Saccharomyces cerevisiae
• Alignment Length: 563
• Identity: 158/563 - (28%)
• Similarity: 245/563 - (43%)
• Gaps: 138/563 - (24%)

  Fly    29 KSGLKGVAHPRTKGTIKRLQMYRNFKAKRDRTGKILTPAPFQGRLPAGTMARVEPTPKWFSN--- 90
            |.|:|..|....|   |..:|     ||:|.|.:                :|.:..|...||
Yeast    16 KEGIKKKASAHRK---KEKKM-----AKKDVTWR----------------SRSKKDPGIPSNFPY 56

  Fly    91 -SRVISQTALQKFQD------------EIGKAVKDP-----YQVIMKPSQLPVTLLNEAAKYKRV 137
             ::::.:...:|.:|            |..||.|:.     .:.:::..:..:..|.|:|:....
Yeast    57 KAKILEEIEAKKMKDLEERELAKQQRLEARKAAKEQGVDAMDEDMIEDDENGLAALVESAQQAAA 121

  Fly   138 HLLDTESFDSTFGPKKQRKRVSLKVRDLEDLSKAADDQADKYDSAKDLDLIREDT-GEKKAVRDW 201
            ....|.|.|:             .||         ||:.|..|  .::|...||. ||.:..:
Yeast   122 EYEGTPSNDA-------------DVR---------DDELDVID--YNIDFYGEDVEGESELEK-- 160

  Fly   202 VFGAGQSKRIWNELHK-VVDASDVLLQVLDARDPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLV 265
                  |::.::::.| |:|||||:|.|||||||..|||:.:||.:.:.: .|.|..|||||||:
Yeast   161 ------SRKAYDKIFKSVIDASDVILYVLDARDPESTRSRKVEEAVLQSQ-GKRLILILNKVDLI 218

  Fly   266 PVWVTQRWVAILSAEYPTI------------AFHASLQHPFGKGALINLFRQLGKLHLDKKQISV 318
            |..|.::|:..|.:.:|||            :|:..|.......||:...:........|:.|.|
Yeast   219 PPHVLEQWLNYLKSSFPTIPLRASSGAVNGTSFNRKLSQTTTASALLESLKTYSNNSNLKRSIVV 283

  Fly   319 GFIGYPNVGKSSVINALRSK-----KVCKVAPIAGETKVWQYITLMKRIFLIDCPGVVYPT---- 374
            |.|||||||||||||||.::     |.|.|...||.|...:.|.:..::.::|.||:.:|:
Yeast   284 GVIGYPNVGKSSVINALLARRGGQSKACPVGNEAGVTTSLREIKIDNKLKILDSPGICFPSENKK 348

  Fly   375 ---AETDTEKVLKGVVRVELVTNPEDYVDSLLKRV-----RPEYISKNYKI-----EHWNTST-H 425
               .|.:.|..|...:..:.:.:|...|..|:||:     ..|...|.|:|     ...:|.| |
Yeast   349 RSKVEHEAELALLNALPAKHIVDPYPAVLMLVKRLAKSDEMTESFKKLYEIPPIPANDADTFTKH 413

  Fly   426 FLEQLAQKTGKLLKGGEPDVTVTARMVLNDWQRGKLPFYVPPEGFAVPKSQEGKEEEVVAEDPNE 490
            ||..:|:|.|:|.|||.|::......|||||:.||:..:|.|...|....|:.:....:    |.
Yeast   414 FLIHVARKRGRLGKGGIPNLASAGLSVLNDWRDGKILGWVLPNTSAAASQQDKQNLSTI----NT 474

  Fly   491 DAKSEAP------TFVSE------------SVKKAREFKQIQD 515
            ..| :||      |.|||            |:.||.:..:.||
Yeast   475 GTK-QAPIAANESTIVSEWSKEFDLDGLFSSLDKAIDASKDQD 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	26/150 (17%)
		NGP_1	214..370	CDD:206751	68/173 (39%)
		PTZ00121	<474..657	CDD:173412	14/60 (23%)
NUG1	NP_010921.1	GN3L_Grn1	13..89	CDD:462569	19/96 (20%)
		MMR_HSR1	<138..214	CDD:460387	32/86 (37%)
		Nucleostemin_like	177..340	CDD:206753	63/163 (39%)