Protein Alignment Ns2 and GNL3L

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_061940.1
• Gene: GNL3L / 54552
• HGNCID: 25553
• Length: 582
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 163/613 - (26%)
• Similarity: 259/613 - (42%)
• Gaps: 144/613 - (23%)

  Fly    96 QTALQKFQDEIGKAVKDPYQVIMKPSQLPVTLLNEAAKYKRVHLLDTESFDSTFGPKKQRKRVSL 160
            |.|.|..:....|....|:.|      .|....|..|:.|:..:.:..........::::||.::
Human    27 QPAKQNGKKATSKVPSAPHFV------HPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTI 85

  Fly   161 KVRDLEDLSKAADDQADKYDSAKDLDLI--REDTGEKKAVRDWVFGAGQSKRIWNELHKVVDASD 223
            : ...:|:.:..::...|.:..::|::.  .:|...:||             .:.|..|||:.||
Human    86 E-SYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKA-------------YYKEFRKVVEYSD 136

  Fly   224 VLLQVLDARDPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLVPVWVTQRWVAILSAEYPTIAFHA 288
            |:|:|||||||:|.|...:||.:.:.:.:|.|..:|||:||||..|.::|:..|..|.||:||.|
Human   137 VILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKA 201

  Fly   289 SLQHP------------------------FGKGALINLFRQLG---KLHLDKKQISVGFIGYPNV 326
            |.||.                        ||..   ||.|.||   :|...:..|.||.:|.|||
Human   202 STQHQVKNLNRCSVPVDQASESLLKSKACFGAE---NLMRVLGNYCRLGEVRTHIRVGVVGLPNV 263

  Fly   327 GKSSVINALRSKKVCKVAPIAGETKVWQYITLMKRIFLIDCPGVVYPTAETDTEKVLKGVVRVEL 391
            ||||:||:|:..:.|.|..:.|.||..|.:.|.|.|.|:|.||:| |...::...:|:..|.|:.
Human   264 GKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIV-PGPNSEVGTILRNCVHVQK 327

  Fly   392 VTNPEDYVDSLLKRVRPEYISKNYKIEHWNTSTHFLEQLAQKTGKLLKGGEPDVTVTARMVLNDW 456
            :.:|...|:::|:|...|.||..|.:..:.|:.|||..:|.:.||..|||.......|:.||.||
Human   328 LADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADW 392

  Fly   457 QRGKLPFYVPPEGFAVPKSQEGKEEEVVAEDPNEDAKSEAPTFVS-ESVKKAREFKQIQDFRKIR 520
            ..||:.||:||                       .|....||.:| |.||:..|...|:|
Human   393 VSGKISFYIPP-----------------------PATHTLPTHLSAEIVKEMTEVFDIED----- 429

  Fly   521 VGLEYEQED-------------VKDLDHIDLEL----LEQQKAERAAKKKARIHNLGE------- 561
              .|...||             :.|.|.:::|:    ....|...|.:.|..::.:|:
Human   430 --TEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTN 492

  Fly   562 -------------EDEESSDGADEFYSEDEYNEDLQRVV----------------HKKAKSKKPQ 597
                         :....|:...:..|.|. ...|||::                :||...|:..
Human   493 PNRHQMGWAKRNVDHRPKSNSMVDVCSVDR-RSVLQRIMETDPLQQGQALASALKNKKKMQKRAD 556

  Fly   598 QLAITSSGKFRVAKIQPGDSDGAGSSDD 625
            ::|...|.....|      .|.:|::||
Human   557 KIASKLSDSMMSA------LDLSGNADD 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	13/82 (16%)
		NGP_1	214..370	CDD:206751	74/182 (41%)
		PTZ00121	<474..657	CDD:173412	36/206 (17%)
GNL3L	NP_061940.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		8/36 (22%)
		Required for nucleolar localization	9..35		3/7 (43%)
		Nucleostemin_like	136..307	CDD:206753	69/173 (40%)