Protein Alignment Ns2 and gnl3

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_001002297.1
• Gene: gnl3 / 321897
• ZFINID: ZDB-GENE-030131-616
• Length: 561
• Species: Danio rerio
• Alignment Length: 644
• Identity: 159/644 - (24%)
• Similarity: 267/644 - (41%)
• Gaps: 132/644 - (20%)

  Fly    38 PRTKGTIKRLQMYRNFKAK---RDRTGKILTPAPFQGRLPAGTMARVEPTPKWFSNSRVISQTAL 99
            |:.|...|||...:.:|.:   |:...|:...|..||                      ||:
Zfish     4 PKLKKASKRLSCAKRYKIQKKVREHNRKLKKAAKKQG----------------------ISR--- 43

  Fly   100 QKFQDEIGKAVKDPYQVIMKPSQLPV--TLLNEAAKYKRVHLLDTESFDSTFGPKKQRKRVSLKV 162
                    ||.||    |..|:..|.  .:|.||.:.|:    :.|:........||:::.:.:.
Zfish    44 --------KAKKD----IGVPNSAPFKEEVLREAEQRKQ----ELETLKEQNKIVKQQEKAAKRK 92

  Fly   163 RDLEDLSKAADDQADKYDSAKDLDLIREDTGEKKAVRDWVFGAGQSKRIWNELHKVVDASDVLLQ 227
            ::.:..|...:..|.|...|..:...|....:.|:.:.:.         ..||:||::||||:::
Zfish    93 KEKDAASSVKEPAAKKAKKAAKIKEARAAIVKVKSAKTFK---------CQELNKVIEASDVIVE 148

  Fly   228 VLDARDPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLVPVWVTQRWVAILSAEYPTIAFHASLQ- 291
            |||||||:|.|...:||.:.|.:..|.|.|||||:||||....::|:..|.||.||..|.:|:|
Zfish   149 VLDARDPLGCRCPQLEEMVLKHEGKKKLLFILNKIDLVPKDNLEKWLHFLEAECPTFLFKSSMQL 213

  Fly   292 -------------------HP-----FGKGALINLFRQLGKLHLDKKQISVGFIGYPNVGKSSVI 332
                               |.     |||..|:.....|......:..:.||.:|:|||||||:|
Zfish   214 KDRTVQQKRQQRGTNAVLDHSRAASCFGKDFLLQTLNDLANKKEGETMLKVGVVGFPNVGKSSII 278

  Fly   333 NALRSKKVCKVAPIAGETKVWQYITLMKRIFLIDCPGVVYPTAETDTEKVLKGVVRVELVTNPED 397
            |:|:..:.|......|.|:..|.:.:.|::.:||.||::...:...:...|:.:...|...:|::
Zfish   279 NSLKEMRACNAGVQRGLTRCMQEVHITKKVKMIDSPGILAALSNPGSAMALRSLQVEEKEESPQE 343

  Fly   398 YVDSLLKRVRPEYISKNYKIEHWNTSTHFLEQLAQKTGKLLKGGEPDVTVTARMVLNDWQRGKLP 462
            .|.:|||:...:::...|.:..:.:|..||...|.|.|.|.|||..|..:.|...||||...||.
Zfish   344 AVRNLLKQCNQQHVMLQYNVPDYRSSLEFLTTFAMKHGLLQKGGVADTELAATTFLNDWTGAKLS 408

  Fly   463 FYV-PPEGFAVPKSQEGKEEEVVAEDPNEDAKSEAPTFVSESVKKAREFKQIQDFRKIRVGLEYE 526
            :|. .||...:|...    .:.:..:...|...:|....:|:||::..|..:...      :.::
Zfish   409 YYSRVPERQGLPSYL----SDAIVTELQSDVDMDAVKKGNENVKRSVRFPNLASC------ISFD 463

  Fly   527 QE----DVKDLDHIDLELLEQQKAERAAKKKARIHNLGEEDEESSDGADEFYSEDEYNEDLQRVV 587
            ..    .|.|:..:..|:|         .|.|...:..||..:::...||..:|...:..::.:.
Zfish   464 SSGPTAGVLDVSELPKEIL---------TKAATTTDAEEEKMDTTTNTDEPEAESHISSTVEPIQ 519

  Fly   588 HKKAKSK-KPQQLAITSSGKFRVAKIQPGDSDGAGSSDDDGPSTSKAPRLTAKQKRSLE 645
            ....|.| ||.          :..|..|.::|                 ||:.|.::.|
Zfish   520 EPTEKRKDKPA----------KEVKFVPVNTD-----------------LTSMQNKNNE 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	24/134 (18%)
		NGP_1	214..370	CDD:206751	67/180 (37%)
		PTZ00121	<474..657	CDD:173412	28/177 (16%)
gnl3	NP_001002297.1	GN3L_Grn1	15..85	CDD:462569	21/110 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..58		13/66 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..110		5/33 (15%)
		Nucleostemin_like	144..316	CDD:206753	61/171 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	486..532		10/55 (18%)