Protein Alignment Ns2 and GNL2

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_001310552.1
• Gene: GNL2 / 29889
• HGNCID: 29925
• Length: 799
• Species: Homo sapiens
• Alignment Length: 795
• Identity: 356/795 - (44%)
• Similarity: 473/795 - (59%)
• Gaps: 148/795 - (18%)

  Fly    10 KPRTQG---FNHSNHSMNPERPKSGLKGVAHPRTKGTIKRLQMYRNFKAKRDRTGKILTPAPFQG 71
            ||:.:|   .|.|..|.||:|.:..  |..:.|.:.||:||.|||. |.:|:..|||:.|..:|.
Human     3 KPKYKGRSTINPSKASTNPDRVQGA--GGQNMRDRATIRRLNMYRQ-KERRNSRGKIIKPLQYQS 64

  Fly    72 RLPAGTMARVEPTPKWFSNSRVISQTALQKFQDEIGKAVKDPYQVIMKPSQLPVTLLNEAAK--Y 134
            .:.:||:|||||..|||.|:|||.|::|||||:|:...:||||:|:||.|:||::||::..:  .
Human    65 TVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVVMKQSKLPMSLLHDRIRPHN 129

  Fly   135 KRVHLLDTESFDSTFGPKKQRKRVSLKVRDLEDLSKAADDQADKYDSAKDLDLIREDTGEKKAVR 199
            .:||:||||||::|||||.||||.:|...|::.|.:.|:...:.||..||.||:.||||.:...:
Human   130 LKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDRDLVTEDTGVRNEAQ 194

  Fly   200 DWVFGAGQSKRIWNELHKVVDASDVLLQVLDARDPMGTRSKYIEEFLRKEKPHKHLFFILNKVDL 264
            :.::..|||||||.||:||:|:|||::|||||||||||||.:||.:|:||||.|||.|:|||.||
Human   195 EEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDL 259

  Fly   265 VPVWVTQRWVAILSAEYPTIAFHASLQHPFGKGALINLFRQLGK--------------------- 308
            ||.|.|:||||:||.:|||:||||||.:||||||.|.|.||.||
Human   260 VPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKPWHLTFHALLGFPGLLCILCP 324

  Fly   309 -----------------------------------------------LHLDKKQISVGFIGYPNV 326
                                                           ||.|||||||||||||||
Human   325 WSPCSFYVLWLERALPKFKLQIPGQTSAPEGSRGTRLPYQILKASCSLHTDKKQISVGFIGYPNV 389

  Fly   327 GKSSVINALRSKKVCKVAPIAGETKVWQYITLMKRIFLIDCPGVVYPTAETDTEKVLKGVVRVEL 391
            |||||||.|||||||.|||||||||||||||||:|||||||||||||:.:::|:.||||||:||.
Human   390 GKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEK 454

  Fly   392 VTNPEDYVDSLLKRVRPEYISKNYKIEHWNTSTHFLEQLAQKTGKLLKGGEPDVTVTARMVLNDW 456
            :.:|||::.::|:|.:||||||.|||:.|..:..|||:||.:|||||||||||:....:||||||
Human   455 IKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDW 519

  Fly   457 QRGKLPFYVPP---EGFAVPKSQEGKEEEVVAE----DPNEDAKSEAPTFVSESVKKAR------ 508
            |||::||:|.|   |....|:.......|||.|    :|.|:. :|.....|||:.|..
Human   520 QRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEV-TETAGEGSESIIKEETEENSH 583

  Fly   509 -----EFKQI-----QDFRKIRVGLEYEQEDVKDLDHIDLELLEQQKAERAAKKKARIHNLGEED 563
                 |.:||     |:|.||.|..::..:|:..::..|||    ::.|..:.::.      ||.
Human   584 CDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLE----EELESFSDEEE------EEQ 638

  Fly   564 EESSDGADEFYSEDE---YNEDLQRVV----HKKAKSKKPQQLAITSSGKFRVAKIQPGDSDGAG 621
            |:..|.|:|..||.|   ...|.:.|:    .|.||.:|  .|....:.||...:|..|.|:...
Human   639 EQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQK--FLDKAKAKKFSAVRISKGLSEKIF 701

  Fly   622 SS------------DDDGPS----------------TSKAPR-LTAKQKRSLERSQKRKKIGSNF 657
            :.            ||..||                ::|||| ||:|::|...|.|:.||:|..:
Human   702 AKPEEQRKTLEEDVDDRAPSKKGKKRKAQREEEQEHSNKAPRALTSKERRRAVRQQRPKKVGVRY 766

  Fly   658 YETTNVKNRNRNKKK 672
            |||.|||||||||||
Human   767 YETHNVKNRNRNKKK 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	64/131 (49%)
		NGP_1	214..370	CDD:206751	124/223 (56%)
		PTZ00121	<474..657	CDD:173412	62/238 (26%)
GNL2	NP_001310552.1	NGP1NT	43..174	CDD:462379	64/131 (49%)
		NGP_1	209..433	CDD:206751	124/223 (56%)
		RbgA	218..524	CDD:440775	172/305 (56%)