Protein Alignment Ns2 and GNL1

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_005266.2
• Gene: GNL1 / 2794
• HGNCID: 4413
• Length: 607
• Species: Homo sapiens
• Alignment Length: 700
• Identity: 131/700 - (18%)
• Similarity: 226/700 - (32%)
• Gaps: 268/700 - (38%)

  Fly   111 KDPYQVIMKPSQL---------------PVTLLNEAAKYKRVHLLDTESFDST------------ 148
            |.|:.|..|..||               ..:.....::.:|....||...:|.
Human     4 KKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRRLNQQPS 68

  Fly   149 -------FGPKKQRKRVSLKVR-DLEDLSKAADDQADKYDSAKDLDL-IRE-------------- 190
                   :.|.:.|.......| ::|...:||.:|..:..||:.|:| |||
Human    69 QGLGPRGYDPNRYRLHFERDSREEVERRKRAAREQVLQPVSAELLELDIREVYQPGSVLDFPRRP 133

  Fly   191 -----------DTGEKKAVRDW---VFGAGQSKRI---------WNELHKVVDASDVLLQVLDAR 232
                       .:.|:::.:|:   :.||..|:::         |.:|.:|::.||::|.:.|.|
Human   134 PWSYEMSKEQLMSQEERSFQDYLGKIHGAYSSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIR 198

  Fly   233 DPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLVPVWVTQRWVAILSAEYPTI------AFHASLQ 291
            .|:......:.|::..|. ...|..:||||||.|..:...|.......||.:      :|....:
Human   199 HPVVNFPPALYEYVTGEL-GLALVLVLNKVDLAPPALVVAWKHYFHQHYPQLHVVLFTSFPRDPR 262

  Fly   292 HPFGKGALINLFRQ----------------------LGKLHLDKKQ------------------- 315
            .|....:::...|:                      :||:.|...:
Human   263 TPQDPSSVLKKSRRRGRGWTRALGPEQLLRACEAITVGKVDLSSWREKIARDVAGATWGNGSGEE 327

  Fly   316 ---------------------------------ISVGFIGYPNVGKSSVINALRSKKVCKVAPIA 347
                                             :::|.:|:|||||||:||.|..:||..|:...
Human   328 EEEEDGPAVLVEQQTDSAMEPTGPTQERYKDGVVTIGCVGFPNVGKSSLINGLVGRKVVSVSRTP 392

  Fly   348 GETKVWQYITLMKRIFLIDCPGVVYPTAETDTEKVLKGVVRVELVTNPEDYVDSLLKRV------ 406
            |.|:.:|...|...:.|.||||:::|:......:||.|:..:..:..|...|..|..|:
Human   393 GHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTAVGYLASRIPVQALL 457

  Fly   407 ---RPEYISKNYKIEH----WNTSTHFLEQLAQKTGKLLKGGEPDVTVTARMVLNDWQRGKLPFY 464
               .||  :::...||    |:....:.|:...||.|..:.   ||...|..:|.....|:|...
Human   458 HLRHPE--AEDPSAEHPWCAWDICEAWAEKRGYKTAKAARN---DVYRAANSLLRLAVDGRLSLC 517

  Fly   465 VPPEGFAVPKSQEGKEEEVVAEDPNEDAKSEAPTFVSESVKKAREFKQIQDFRKIRVGLEYEQED 529
            ..|.|::   .|:|                     ..||..:..|...:|.    |||...::|:
Human   518 FHPPGYS---EQKG---------------------TWESHPETTELVVLQG----RVGPAGDEEE 554

  Fly   530 VKDLDHIDLELLEQQKAERAAKKKARIHNLGEEDEESSDGADEFYSEDEYNEDLQRVVHKKAKSK 594
                                           ||:||.|...:|...||.
Human   555 -------------------------------EEEEELSSSCEEEGEEDR---------------- 572

  Fly   595 KPQQLAITSSGKFRVAKIQPGDSDGAGSSDDDGPSTSKAPRLTAKQKRSL 644
                                 |:|..|..|::.|:::....|..:...:|
Human   573 ---------------------DADEEGEGDEETPTSAPGSSLAGRNPYAL 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	17/102 (17%)
		NGP_1	214..370	CDD:206751	50/235 (21%)
		PTZ00121	<474..657	CDD:173412	24/170 (14%)
GNL1	NP_005266.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		11/76 (14%)
		RbgA	173..514	CDD:440775	74/346 (21%)
		HSR1_MMR1	177..418	CDD:206750	52/241 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..607		16/122 (13%)