Protein Alignment Ns2 and Gnl3l

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_932778.1
• Gene: Gnl3l / 237107
• MGIID: 2448557
• Length: 577
• Species: Mus musculus
• Alignment Length: 610
• Identity: 166/610 - (27%)
• Similarity: 263/610 - (43%)
• Gaps: 144/610 - (23%)

  Fly   108 KAVKDP-----YQVIMKPSQLP-VTLLNEAA------KYKRVHLLDTESFDSTFGPKKQRKRVSL 160
            |..|.|     .:|..:||..| :...|:.|      |.|||..:..:   .....:::|:|...
Mouse    16 KGCKKPARQNGKKVTSRPSSAPQIVHGNDHASREAELKKKRVEEMREK---QQVAREQERQRHRT 77

  Fly   161 KVRDLEDLSKAADDQADKYDSAKDLDLI--REDTGEKKAVRDWVFGAGQSKRIWNELHKVVDASD 223
            .....:|:.|...:...|.:..::|::.  .:|...:||             .:.|..|||:.||
Mouse    78 MESYCQDVLKRQQEFEQKEEVLQELNMFPQLDDEATRKA-------------YYKEFRKVVEYSD 129

  Fly   224 VLLQVLDARDPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLVPVWVTQRWVAILSAEYPTIAFHA 288
            |:|:|||||||:|.|...:||.:.:.:.:|.|..:|||:||||..:.::|:..|..|.||:||.|
Mouse   130 VILEVLDARDPLGCRCFQMEETVLRAEGNKKLVLVLNKIDLVPKEIVEKWLEYLLNELPTVAFKA 194

  Fly   289 SLQHP-------------------------FGKGALINLFRQLG---KLHLDKKQISVGFIGYPN 325
            |.||.                         ||..   ||.|.||   :|...:..|.||.:|.||
Mouse   195 STQHHQVKNLTRCKVPVDQASESLLKSRACFGAE---NLMRVLGNYCRLGEVRGHIRVGVVGLPN 256

  Fly   326 VGKSSVINALRSKKVCKVAPIAGETKVWQYITLMKRIFLIDCPGVVYPTAETDTEKVLKGVVRVE 390
            |||||:||:|:..:.|.|..:.|.||..|.:.|.|.|.|:|.||:| |...::...:|:..:.|:
Mouse   257 VGKSSLINSLKRSRACSVGAVPGVTKFMQEVYLDKFIRLLDAPGIV-PGPNSEVGTILRNCIHVQ 320

  Fly   391 LVTNPEDYVDSLLKRVRPEYISKNYKIEHWNTSTHFLEQLAQKTGKLLKGGEPDVTVTARMVLND 455
            .:.:|...|:::|:|...|.||..|.:..:.|:.|||..:|.:.||..|||.......|:.||.|
Mouse   321 KLADPVTPVETILQRCNLEEISSYYGVSGFQTTEHFLTAVAHRLGKKKKGGVYSQEQAAKAVLAD 385

  Fly   456 WQRGKLPFY-VPPEGFAVPKSQEGKEEEVVAEDPNEDAKSEAPTFVS-ESVKKAREFKQIQDFRK 518
            |..||:.|| :||....:                        ||.:| |.||:..|...|:|
Mouse   386 WVSGKISFYTLPPPTHTL------------------------PTHLSAEIVKEMTEVFDIED--- 423

  Fly   519 IRVGLEYEQED------VKDLDHI--DLELLEQQ---------KAERAAKKKARIHNLGE----- 561
                .|:..||      |.:.|.:  |::..|.:         |...|.:.::.::.:|.
Mouse   424 ----TEHANEDTMECLAVGESDELLGDMDPQEMEVRWLHSPLVKIADAIENRSTVYKIGNLTGYC 484

  Fly   562 -EDEESSDGADEFYSEDEYNEDLQRVVHKKAKSKKP--------------QQLAITSSGKFRVAK 611
             :...:..|..: .:.|.:.....|||...:..::|              |.||.....|.::.|
Mouse   485 TKPNRNQMGWPK-RNVDHHCPQNNRVVEVSSVDRRPMLQRILETDPLQQGQALASALKNKKKLQK 548

  Fly   612 ------IQPGDS-----DGAGSSDD 625
                  .:..||     |.:|:|||
Mouse   549 RSDKIATKLSDSMMSMLDLSGNSDD 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	17/82 (21%)
		NGP_1	214..370	CDD:206751	73/183 (40%)
		PTZ00121	<474..657	CDD:173412	37/201 (18%)
Gnl3l	NP_932778.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		14/61 (23%)
		Required for nucleolar localization. /evidence=ECO:0000250	9..28		3/11 (27%)
		PTZ00121	<19..166	CDD:173412	42/162 (26%)
		Nucleostemin_like	129..301	CDD:206753	68/174 (39%)