Protein Alignment Ns2 and ngp-1

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_492275.2
• Gene: ngp-1 / 172624
• WormBaseID: WBGene00003596
• Length: 651
• Species: Caenorhabditis elegans
• Alignment Length: 676
• Identity: 304/676 - (44%)
• Similarity: 416/676 - (61%)
• Gaps: 102/676 - (15%)

  Fly    16 FNHSNHSMNPERPKSGLKGVAHPRTKGTIKRLQMYRNFKAKRDRTGKILTPAPFQGRLPAGTMAR 80
            |..|||||||:| |...|..:. |:|.||.||:||::||..||..||||..||||..|.:||.||
 Worm    29 FRGSNHSMNPDR-KPDAKDKSQ-RSKATINRLRMYKSFKPIRDSKGKILKAAPFQDTLASGTQAR 91

  Fly    81 VEPTPKWFSNSRVISQTALQKFQDEIGKAVKDPYQVIMKPSQLPVTLLNEAAKYKRVHLLDTESF 145
            :||..|||.|:|:|.|..|||||..:||.:.||:||:||.::||::||.|.||.:|||:.:||||
 Worm    92 IEPNRKWFGNTRIIGQEQLQKFQANLGKVLSDPFQVVMKQTKLPISLLQEKAKTQRVHVTETESF 156

  Fly   146 DSTFGPKKQRKRVSLKVRDLEDLSKAADDQADKYDSAKDLDLIRE-DTGEKKAVRDWVFGAGQSK 209
            :.|||.|..||:..|....||::||:|:|:..||  ..:|||.|| :.|::....:.:|.||||.
 Worm   157 EYTFGKKSLRKKAKLTEASLEEMSKSAEDRDVKY--KPELDLSREKELGDRPENMNPLFRAGQSN 219

  Fly   210 RIWNELHKVVDASDVLLQVLDARDPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLVPVWVTQRWV 274
            |:|.||:||:|:|||::||:|||||||||.:::|||||||||||||..::|||||||.|||::|:
 Worm   220 RVWGELYKVIDSSDVVVQVVDARDPMGTRCRHVEEFLRKEKPHKHLVTVINKVDLVPTWVTRKWI 284

  Fly   275 AILSAEYPTIAFHASLQHPFGKGALINLFRQLGKLHLDKKQISVGFIGYPNVGKSSVINALRSKK 339
            ..||.|.||||||||:.:.|||||:|||.||..|||.|:.||||||||||||||||::|.||.||
 Worm   285 GELSKEMPTIAFHASINNSFGKGAVINLLRQFAKLHPDRPQISVGFIGYPNVGKSSLVNTLRKKK 349

  Fly   340 VCKVAPIAGETKVWQYITLMKRIFLIDCPGVVYPTAETDTEKVLKGVVRVELVTNPEDYVDSLLK 404
            |||.||||||||||||:.||:||:|||.||||||..:::|:.:||||||||.|.:||::|..:|.
 Worm   350 VCKTAPIAGETKVWQYVMLMRRIYLIDSPGVVYPQGDSETQIILKGVVRVENVKDPENHVQGVLD 414

  Fly   405 RVRPEYISKNYKIEHWNTSTHFLEQLAQKTGKLLKGGEPDVTVTARMVLNDWQRGKLPFYVPPEG 469
            |.:||::.:.|.|..:.....||.::|.|.|:|||||:||:...:::|||::||||||::|||.|
 Worm   415 RCKPEHLRRQYGIPEFTDVDDFLTKIAIKQGRLLKGGDPDIVAVSKVVLNEFQRGKLPYFVPPPG 479

  Fly   470 FAVPKSQEGKEEEVVAEDPNEDAKSEAPTFVSESVKKAREFKQIQDFRKIRVGLEYEQEDVKDLD 534
            .          ||...:|     .|:||  ::|..        ..|..::.:..:.|.:||
 Worm   480 C----------EERAKKD-----FSQAP--INEMC--------ADDDEQLPLDAQLELDDV---- 515

  Fly   535 HIDLELLEQQKAERAAKKKARIHNLGEEDEESSDGADEFYSEDEYNEDLQRVVHKKAKSKKPQQL 599
                               ||.....|:|:|:.|        ||..|:|             .::
 Worm   516 -------------------ARNGGPDEDDDEAID--------DEEQEEL-------------TEI 540

  Fly   600 AITSSGKFRVAKIQPGDSDGAG--------SSDDDGPSTSKAPRLTAKQ---------KRSLERS 647
            ..|.||...::    |.||.||        :.||:.||:|.:....:|.         ||..:::
 Worm   541 GSTCSGLTDLS----GISDLAGDLSDADDVADDDEKPSSSDSKTKKSKTDVASVRTRGKRGGKKA 601

  Fly   648 QKRKKIGSNFYETTNVKNRNRNKKKD 673
            .|.|..|....:..       ::|||
 Worm   602 NKAKLSGKTIVQAA-------SEKKD 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	68/129 (53%)
		NGP_1	214..370	CDD:206751	112/155 (72%)
		PTZ00121	<474..657	CDD:173412	40/199 (20%)
ngp-1	NP_492275.2	NGP1NT	60..190	CDD:462379	68/129 (53%)
		NGP_1	224..380	CDD:206751	112/155 (72%)
		P-loop containing Nucleoside Triphosphate Hydrolases	329..461	CDD:476819	76/131 (58%)