Protein Alignment Ns2 and Ns3

DIOPT Version :10

• Sequence 1: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: XP_061509955.1
• Gene: Ns3 / 1278372
• VectorBaseID: AGAMI1_012430
• Length: 624
• Species: Anopheles gambiae
• Alignment Length: 722
• Identity: 154/722 - (21%)
• Similarity: 265/722 - (36%)
• Gaps: 232/722 - (32%)

  Fly    54 KAKRDRTGKILTPAPF-QGR---LPAGTMARVEPTPKWFSNSRVISQTALQK--FQDEIGKA--V 110
            |.|.::.|:.|....| ||.   :..|:|.........:...|:..|:..::  ||:.:..|  .
Mosquito     3 KKKANQLGRSLIKDRFGQGNRKTVADGSMLHTTEVQDGYDWGRLNLQSVTEESSFQEFLRTAELA 67

  Fly   111 KDPYQVIMKPSQLPVTLLNEAAKYKRVHLLDTESFDSTFGPKKQRKRVSLKVRDLEDLSK-AADD 174
            ...:|.    .:|.:|.:|..:|   |.||.|          .:|..:..|..|::||.| ....
Mosquito    68 GTEFQA----EKLNITYVNPKSK---VGLLTT----------NERVEIIKKQVDMKDLLKIPRRP 115

  Fly   175 QADKYDSAKDLDLIREDTGEKKAVRDWVFGA--------------GQSKRIWNELHKVVDASDVL 225
            :..|..:|::|.|     .|..:..:|..|.              .::...|.:|.:||:.||::
Mosquito   116 KWTKDTTAEELLL-----AENASFLEWRRGLVALQEQDGMLMTPYEKNLDFWRQLWRVVERSDIV 175

  Fly   226 LQVLDARDPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLVPVWVTQRWVAILSAEYPTIAFHASL 290
            :|::|||:|:..|::.:|.::::..|:|....:|||.|.:.......|......:...:||::::
Mosquito   176 VQIVDARNPLLFRTEDLERYVQEVDPNKMNMILLNKSDFLTAEQRVHWAKYFDGQGVRVAFYSAV 240

  Fly   291 ----------------------------------------------------------------- 290
                                                                             
Mosquito   241 LAAEEAKKEQEAEEAAQQAAQNGDQADDEEEEEEKEQEEVKERLGNLKLSVDRAEKTLEKIEEKI 305

  Fly   291 -----QHPFGKGA------------LINLFRQLGKL-HLDKKQISVGFIGYPNVGKSSVINALRS 337
                 :.....||            ||.||:.|.:. .:.|..::||.:|||||||||.|||:..
Mosquito   306 EDLAREEDAEPGAIRNSSKLLTNAELIALFKSLHRAERVTKDVVTVGLVGYPNVGKSSTINAVFL 370

  Fly   338 KKVCKVAPIAGETKVWQYITLMKRIFLIDCPGVVYPT-AETDTEKVLKGVVRVELVTN---PEDY 398
            :|...|:...|:||.:|.:.:...:...||||:|.|: ..|..:.:|.|::.::.:.:   |.:.
Mosquito   371 EKKVSVSATPGKTKHFQTLYVDSELMFCDCPGLVMPSFCITKADMILNGILPIDQMRDHVPPVNL 435

  Fly   399 VDSLLKR--VRPEY---ISKNYKIEHWNT---STHFLEQLAQKTGKLLKGGEPDVTVTARMVLND 455
            :.:|:.|  :...|   |||..:.|..|.   |...|...|...|.:...|:||.:..:|.||.|
Mosquito   436 LCTLIPRHILEDTYGIMISKPLEGEDPNRPPYSEELLLAFAYNRGFMTANGQPDQSRGSRYVLKD 500

  Fly   456 WQRGKLPFYVPPEGFAVPKSQEGKEEEVVAEDPNEDAKSEAPTFVSESVKKAREFKQIQDFRKIR 520
            :..|||.:...|.|.                                          :||
Mosquito   501 YVNGKLLYCYAPPGV------------------------------------------VQD----- 518

  Fly   521 VGLEYEQEDVKDLDHIDLELL--EQQKAERAAKKKARIHNLGEEDEESSDGADEFYSEDEYNEDL 583
               |:.:...:..:..|::||  .||:|.:...||:           |:|..::|:.|
Mosquito   519 ---EFHRFPARKKEEADIKLLPPRQQRAMKMNLKKS-----------STDVDEQFFKE------- 562

  Fly   584 QRVVH--KKAKSKKPQQLAITSSGKFRVAKIQPGDSDGAGSSDDDGPSTSKAPRLTAKQKRSLER 646
             |..|  .|.:|..|....|..||            ..|..|..||...:..|  ...|||
Mosquito   563 -RASHGLVKGRSDFPNVRPIGPSG------------SAATLSTTDGVIVAGKP--WKHQKR---- 608

  Fly   647 SQKRKKI 653
             :||:|:
Mosquito   609 -EKREKL 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	29/133 (22%)
		NGP_1	214..370	CDD:206751	52/238 (22%)
		PTZ00121	<474..657	CDD:173412	34/184 (18%)
Ns3	XP_061509955.1	None