DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and TAF3

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_114129.1	Gene:	TAF3 / 83860	HGNCID:	17303	Length:	929	Species:	Homo sapiens

Alignment Length:	1156	Identity:	223/1156 - (19%)
Similarity:	383/1156 - (33%)	Gaps:	399/1156 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1162 MCQTNFYSYSEILCHICPGEVAGSV-YD-LQFRCC--LCDMAPLPSAFRLMVHLRKQHQAC---- 1218
            ||:    |||..|..:...::..:: :| :|...|  |.|:        |..:|::..:.|
Human     1 MCE----SYSRSLLRVSVAQICQALGWDSVQLSACHLLTDV--------LQRYLQQLGRGCHRYS 53

  Fly  1219 ------DICLEDCQSQSKLSSHVWKHKLLHLCYRCGIAYRNKQDISKHLFWKHGTESAGCKQCLQ 1277
                  |..|:|.....:|               .|::....:|
Human    54 ELYGRTDPILDDVGEAFQL---------------MGVSLHELED--------------------- 82

  Fly  1278 KRWRHVYHFCVPPAEFPCEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRKLLLKHA 1342
                  |...:.|..||.:...|..||...|:..|.          ..:..||:
Human    83 ------YIHNIEPVTFPHQIPSFPVSKNNVLQFPQP----------GSKDAEER----------- 120

  Fly  1343 SSHVAKELPQAVSVEQ-------------TADA--APTEKLEDIKEE-------------LEEGE 1379
            ..::...||..||.::             :|:|  .|.|:.::::||             |:..|
Human   121 KEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPE 185

  Fly  1380 DEKEGAHNQEKLLS--------------ESLTNNETPK----------KEESDRIDNSIEPPL-- 1418
            .|:..|..:.:|||              |.|::..|.|          ::.:|....|.|||:
Human   186 AEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLA 250

  Fly  1419 --SKS--------ENRKRRKKSKRNKESLEDLNLIAPNLSESDSSDDSDSDAPRSSHQEQPKLPM 1473
              :||        |.:....|:| .|.|.......:|..::|.:...|...:|::..:|: |.|.
Human   251 PVAKSQMPTAKPLETKSFTPKTK-TKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEK-KSPG 313

  Fly  1474 RSSVDDLDMPKVMLSPSSESDADELDGKSKLEDKEEKPLDGSTEEKALDADDELEPKKEEDQVDV 1538
            ||.     .||   ||.|......:.......:...:....:..||.  :.:.::.|:.:...|.
Human   314 RSK-----SPK---SPKSPKVTTHIPQTPVRPETPNRTPSATLSEKI--SKETIQVKQIQTPPDA 368

  Fly  1539 SIWKNLLQNQAVAIPEEQAVKDEEREDSLVNLPPAKLHVAWSDHDYCKLYRTPAPSPVKQKSANK 1603
            .  |...:||    |::..|.|:..|.|:    .|.:..|.::       |.|.|......|.::
Human   369 G--KLNSENQ----PKKAVVADKTIEASI----DAVIARACAE-------REPDPFEFSSGSESE 416

  Fly  1604 SSIKT-----PGENASSDSDSSSSSSSSDSDSSSCSCGSNCSCSSSNSSSSSGNSDDSDSSTARG 1663
            ..|.|     .|...::...|:|:::.:.|.|:........| ||.||.:...:.|:.......|
Human   417 GDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTS-SSDNSWTMDASIDEVVRKAKLG 480

  Fly  1664 SPQ--------------------------------------KRSRKKSLKVKKSSESLKIDQNGQ 1690
            :|.                                      |:..||.||.|...:..:.|:..:
Human   481 TPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRERE 545

  Fly  1691 NEQN----QVEDTTAVNENNNPVAPPSPKP--PMYNESDFDTAFSDTDEEFYDSHPQ-KLANELL 1748
            .::|    :.:|.....|.:......:..|  ....|.:.| .:....:||.|..|: ||.:.|:
Human   546 KDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEAD-PYKFKIKEFEDVDPKVKLKDGLV 609

  Fly  1749 TQKREALMAEHAPMRPSNNYDIVENSRPSTPSLPEEASAFADKREKVRNKKKKRERKSTCKSGKL 1813
            .:::|    :|...:...                |:.....|||||.:.|.|.||.|.
Human   610 RKEKE----KHKDKKKDR----------------EKGKKDKDKREKEKVKDKGREDKM------- 647

  Fly  1814 QPVASTTPPPMDRIPGMPGMIAPLEPPTPILSHPESSLFP-----VTPLTHRQLQSSMTRMSEGS 1873
                        :.|..|.::.|.|...|:.|...:|..|     :.|:...:|.....::.|
Human   648 ------------KAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKE-- 698

  Fly  1874 SCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVLAPPLQVGMQLIKPQPPPQLTWAKEDLPTPP 1938
                     |..|:.::..|                                    .|::.....
Human   699 ---------KEKKKDKKEKK------------------------------------KKKEKEKEK 718

  Fly  1939 KQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGSRPAKRHKPDPNDHLPPIPTLKIRP 2003
            |::.|.......              .||.|::           ::||.:         .:|:.|
Human   719 KEKEREKEKRER--------------EKREKEK-----------EKHKHE---------KIKVEP 749

  Fly  2004 -SLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQ--PAP-------PPVLPTPLPVALPVPPPP 2058
             :|.|:...|..:....:..:  ::.::.|||.|:  |||       ||..|.|.|..:.|.|.|
Human   750 VALAPSPVIPRLTLRVGAGQD--KIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAP 812

  Fly  2059 PPAATAFNQPIPPALLPNPGFATLQYFKANNIRYPIRPPAGARLAREGESVYCY----------- 2112
            .|..........|||||:||.|.    ...:.:.|:|     .:..|..|.|..
Human   813 VPLPLLAQAAAGPALLPSPGPAA----SGASAKAPVR-----SVVTETVSTYVIRDEWGNQIWIC 868

  Fly  2113 --CRCPYDEVSEMIACDGDNCLIEWFHFECVGIMVAP--QGKWFCAECRPK 2159
              |..| |:.|.||.|  |:| .:|:|:.|||||.||  :.:|||.:|..|
Human   869 PGCNKP-DDGSPMIGC--DDC-DDWYHWPCVGIMTAPPEEMQWFCPKCANK 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	1/15 (7%)
		C2H2 Zn finger	1295..1315	CDD:275370	5/19 (26%)
		C2H2 Zn finger	1323..1341	CDD:275370	2/17 (12%)
		PHD_ING	2110..2156	CDD:276980	22/60 (37%)
TAF3	NP_114129.1	BTP	5..79	CDD:128846	16/96 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..152		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..197		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..358		30/148 (20%)
		PTZ00449	<229..388	CDD:185628	36/176 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..578		28/173 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..658		18/93 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..748		13/136 (10%)
		PRK12323	<777..>847	CDD:237057	26/78 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..807		11/28 (39%)
		PHD_TAF3	867..912	CDD:276997	21/48 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900