DRSC/TRiP Functional Genomics Resources

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Protein Alignment MESR4 and prdm16

DIOPT Version :9

Sequence 1:NP_001097359.1 Gene:MESR4 / 36986 FlyBaseID:FBgn0034240 Length:2171 Species:Drosophila melanogaster
Sequence 2:XP_021334166.1 Gene:prdm16 / 796720 ZFINID:ZDB-GENE-080613-2 Length:1336 Species:Danio rerio


Alignment Length:1563 Identity:296/1563 - (18%)
Similarity:467/1563 - (29%) Gaps:580/1563 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   286 NESPVLEIEGGTEKSQTSGDLYQADVGEYASTAPPEVDETTSQTIGVPSLEGSDTLDSPSLTMDV 350
            |:|..::....||.:..:|:               ..:|.|..:|..|...|.   .||.     
Zfish    13 NDSEAVDSMYDTEPNLVTGE---------------SAEEETEDSIMSPVAVGP---ASPQ----- 54

  Fly   351 DLPCSED-----GAP-------PNVIKIESDMEDEAHSDSVKLKEHTVEVVPL-----IKLNGAH 398
              ||:||     |:|       |:.|.|.:|:|         |:|.:|....|     :|:....
Zfish    55 --PCNEDFTPKEGSPYEVPVYIPDDIPIPADLE---------LRESSVPGAGLGIWAKVKIRMGE 108

  Fly   399 KALKEEKLEDGEVEEVEDPGEELEDPKEQSVITNHTGNNTKEEDTTASQVSALPLILP-VGTTR- 461
            :......|:...|:|.....|::.:..|                 |:||.|.:..::. :|..: 
Zfish   109 RFGPYNGLQSATVKETTYGWEQMLNDHE-----------------TSSQDSCIKKVMDNMGNVKF 156

  Fly   462 ------SRSISSRSSTVSSASQPHLVIDHPESEHNAKPPALKLSLKRRRSKSSSVSQPEKQTK-- 518
                  ..|.|.....|.:|.. ||       |||       |::       ..:|:.:...|  
Zfish   157 CLDGALEASGSCWLKYVRTAPS-HL-------EHN-------LAM-------CHISEDQIYYKAI 199

  Fly   519 --VEAGGFVSSLLLQRLQSNSNVIPP---AISTESQQVLSCAKCNLQFDFERFQELNKHQA-QCS 577
              :|.|   ..||   :.....|.|.   |.:.|.:|:..|..|:..|..:  .||.:||. .||
Zfish   200 RDIEIG---EELL---VYMKDGVFPEGSMAPNLEDEQMYRCEHCDELFTSK--LELRRHQKYSCS 256

  Fly   578 GIQSANS--SQLSQ--KQER------FFRCSQC-------CSVHQCWHFFLHMREVHRRYICLYC 625
               |.||  ..||:  ||||      ...|..|       .|:.|  |..:|..|  |.|.|..|
Zfish   257 ---SGNSIFDSLSEDFKQEREDSDEPVHECKDCEKIFPSEYSLGQ--HMIVHTEE--REYKCDQC 314

  Fly   626 NHVYPSVEKLSLH-----------LENKHDIDQSHFAKDAWDQQ--QSKEDRARHLVCCTCQATF 677
            ...:.....|..|           .||...:..|.|...:..|:  :|:...||...|..|..||
Zfish   315 PKAFNWKSNLIRHQMSHDSGKRFECENCDKVGDSVFTDPSNLQRHIRSQHVGARAHTCPECGKTF 379

  Fly   678 VQGSEFEDH-------------------------DC---SQLMQP-----CA------------- 696
            ...|..:.|                         .|   |:|..|     |.             
Zfish   380 ATSSGLKQHKHIHSSVKPFSCKSEQSCLSLRYNYQCPKTSRLAPPQDCDSCCFIGEVCHKSYTQF 444

  Fly   697 --LCNQKGGHI-----IGCKN--NKRKPTKRRRKVRRPPE------------PPLPVSQEAVEQP 740
              ||..|..|.     |.||:  .....|....|.||..|            |.:|::..     
Zfish   445 SNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYNPGGIFTPGIPMTSS----- 504

  Fly   741 VPVEAIPEQLPQQLHLQSDIQNPFPAENIPAPEPVEDPPAPPIPKLVVPKIMLRVPKEFQKSVDA 805
             |:....:..|...|......:.||:....|..|..  |.||    ..|.|....|..|      
Zfish   505 -PILGKSKSHPGLNHSGLGFGDYFPSRPHHAGLPFS--PGPP----AFPAISHGFPGIF------ 556

  Fly   806 ALSSTDTEDEELETAQPVEEAVSAPPEDLPFDAPPPPPPALSYDDSTSSKLNRVLAELERTKLDI 870
                                    ||...|  .||..||:.......::..:..|..|:...|.:
Zfish   557 ------------------------PPSLYP--RPPLLPPSSLLKSPLNNSQDGKLPHLDAPALSV 595

  Fly   871 ERTKADIITKKQSKIIMANAHLENVVPQVVDPPQHLQPQQEEQRRWSLTPPASPHNNHVNLPEPP 935
                       .|.:..:|.::.:          .|..|.||.|...|....:.:.|.|.:.:  
Zfish   596 -----------ASSMNNSNGNIGS----------SLSSQSEENRESKLDLSFTENKNKVKMND-- 637

  Fly   936 PALITEFQGQPDAVRRNSLGSDCMDMDDSLNAPEMEGSRDFTEAQKETLEPAPPSQDTQTADEPL 1000
               :::.....|.  ..|.|:|......:::..::|...: ::.:|...:||..|:..:.:...:
Zfish   638 ---MSDGSDLEDV--NTSSGTDLDTTTGTVSGSDLESEAE-SDREKSRRKPAQESKQDEVSSSSV 696

  Fly  1001 AIQPLPPADGIMVAGPDTHTVDLQLDRPLDRFSMVDFVRLCLKSVYSLCLYCNHARRIAVNVKQL 1065
            ::               :.:.:|..:||.                                    
Zfish   697 SV---------------SSSGNLPCERPF------------------------------------ 710

  Fly  1066 VIHLIGQHRF------------TATVDSITAEELYAETIVAKLKSFLP---NLENEYMNAASCCS 1115
               |..||.|            .||.|||.|....||      |.|.|   .|:.:.|.:.:..|
Zfish   711 ---LSSQHSFFPPPEEQALPPSGATTDSIKAIASIAE------KYFGPGFMGLQEKKMGSLNYHS 766

  Fly  1116 LENGKYVEPFNERIYECFTCR------FVTSTHKELYTHNRRLHIKSNITCVMCQTNFYSYSEIL 1174
            :...:::..|...:|. ||.|      |.....|....|.::||..:.                 
Zfish   767 MFPFQFLPNFPHSLYP-FTDRALNPGMFFKPEPKSPREHIQKLHTATG----------------- 813

  Fly  1175 CHICPGEVAGSVYDLQFRCCLCDMAPLP-------------------SAFRLMVHLRK------- 1213
                    |.|.:||..:  ..::.|||                   ....|.:..|.       
Zfish   814 --------ADSPFDLTTK--PKEIKPLPPPPSKPALPSNALLASGEEQPLDLSIGSRSRASHNGG 868

  Fly  1214 -------------------QHQACDICLEDCQSQSK----------------------------L 1231
                               :|.|.:..|...|...:                            :
Zfish   869 THEQRKNHVYGTNCKAAKDEHPALNQNLHQPQMPQQHTSLPQPPVPQQQPSLHYAKPSPFFMDPI 933

  Fly  1232 SSHVWKHKLLHLCYRCGIAYRNKQDISKHLFWKHGTESA----------------GCKQCLQKRW 1280
            .|.|.|.|||.........|.....:   ||  |...||                .....||...
Zfish   934 YSRVEKRKLLDPVGALKEKYLRPTPL---LF--HPQVSAMENMTEKLESFSALKLDAPNSLQHSS 993

  Fly  1281 RHVYHFCVPP------------AEFPCEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFV 1333
            .|:::|..||            ..:.|..||.:|.::..|..|.|.|||:..|.|  :.|:..|.
Zfish   994 HHLFNFRSPPPSLSDAILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRC--KYCDRSFS 1056

  Fly  1334 SRKLLLKHASSHVAKELPQAVSV------EQTADAAPTEKLEDIKEELEEGEDEKEGAHNQEKLL 1392
            ....|.:|..:...||.|....:      :||          ::...|::.|.|......|..:|
Zfish  1057 ISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQT----------NLDRHLKKHEHENIPVSQQSGIL 1111

  Fly  1393 SESLTNNETPKK---------EESDRIDNSIEPPLSKSENRKRRKKSKRNKESLEDLN-----LI 1443
            |...||..:|..         |:.|...:.|...:|.||..:....|::..|..|:.:     |.
Zfish  1112 SNLGTNISSPNSESDNHALLDEKEDSYFSEIRNFISNSELNQACSSSEKRSELAEEEHPQSHTLT 1176

  Fly  1444 APNLSESDSSDDSDSDAPRSSHQEQPKLPMRSSVDDLDMPKVMLSPSSESDADELDGKSKLEDKE 1508
            |..|.|.:...:.|.:....|..|:       |.|:...|..|:..:.:            ||:|
Zfish  1177 ASKLEEEEEEMEGDDEDEEGSLTEK-------SQDETASPATMVQGTYD------------EDEE 1222

  Fly  1509 EKPLDGSTE--EKALDADD---ELEP-----------KKEEDQVDVSIWKNLLQNQAVAIPEEQA 1557
            ..||..|.|  .:.::.|.   :|||           |..|:..|:   |::.....    |.:|
Zfish  1223 PTPLPMSYEHTRRCIEEDAGLLDLEPLPGFPKGMEFHKAAEEPYDI---KDIFSPSV----ESEA 1280

  Fly  1558 VKD 1560
            :|:
Zfish  1281 LKE 1283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MESR4NP_001097359.1 C2H2 Zn finger 1272..1288 CDD:275368 4/15 (27%)
C2H2 Zn finger 1295..1315 CDD:275370 7/19 (37%)
C2H2 Zn finger 1323..1341 CDD:275370 4/17 (24%)
PHD_ING 2110..2156 CDD:276980
prdm16XP_021334166.1 SET 85..210 CDD:214614 32/178 (18%)
C2H2 Zn finger 234..275 CDD:275368 18/45 (40%)
C2H2 Zn finger 283..303 CDD:275368 5/21 (24%)
zf-H2C2_2 298..319 CDD:316026 8/24 (33%)
C2H2 Zn finger 311..331 CDD:275368 4/19 (21%)
C2H2 Zn finger 339..361 CDD:275368 5/21 (24%)
zf-C2H2 370..392 CDD:306579 6/21 (29%)
C2H2 Zn finger 372..392 CDD:275368 6/19 (32%)
C2H2 Zn finger 400..454 CDD:275368 8/53 (15%)
C2H2 Zn finger 463..481 CDD:275368 4/17 (24%)
COG5048 998..>1174 CDD:227381 42/187 (22%)
zf-C2H2 1018..1040 CDD:306579 7/21 (33%)
C2H2 Zn finger 1020..1040 CDD:275368 7/19 (37%)
zf-H2C2_2 1032..1056 CDD:316026 9/25 (36%)
zf-H2C2_5 1046..1071 CDD:316431 6/26 (23%)
C2H2 Zn finger 1048..1069 CDD:275368 5/22 (23%)
C2H2 Zn finger 1077..1097 CDD:275368 3/29 (10%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24393
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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