DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and Prdm16

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	XP_006539234.1	Gene:	Prdm16 / 70673	MGIID:	1917923	Length:	1277	Species:	Mus musculus

Alignment Length:	1574	Identity:	285/1574 - (18%)
Similarity:	456/1574 - (28%)	Gaps:	531/1574 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 EEQPSESLGANHESEIDEKV---------------DHFQPKESDSNEVEDKYFQSANEDSESEIE 258
            |..|....|.:.|.|.::.:               :.|.|||.                  |..|
Mouse    23 EPDPDLLAGQSAEEETEDGILSPIPMGPPSPFPTSEDFTPKEG------------------SPYE 69

  Fly   259 ETVYTPPVINLETDSESGDKEFISIKDNESPVLEIEGGTEKSQTSGDLYQADVGEYAST---APP 320
            ..||.|..|.:..|.|        ::::..|...:....::....|:.:    |.|..|   |..
Mouse    70 APVYIPEDIPIPPDFE--------LRESSIPGAGLGIWAKRKMEIGERF----GPYVVTPRAALK 122

  Fly   321 EVD----------ETTSQTIGVPSLEGSDTLDSPSLTMDVDLPCSEDGAPPNVIKIESDMEDEAH 375
            |.|          |.:||...:.. :.|:.|.|....:|.:...|  |:....|::....:|:.
Mouse   123 EADFGWEQMLTDTEVSSQESCIKK-QISEDLGSEKFCVDANQAGS--GSWLKYIRVACSCDDQN- 183

  Fly   376 SDSVKLKEHTVEVVPLIKLNGAHKALKEEKLEDGEVEEVEDPGEELEDPKEQSVITNHTGNNTKE 440
                         :.:.::|        |::....::::| |||||....::...:......:.:
Mouse   184 -------------LAMCQIN--------EQIYYKVIKDIE-PGEELLVHVKEGAYSLGVMAPSLD 226

  Fly   441 EDTTASQVSALPLILPVGTTRSRSISSRSSTVSSASQPHLVIDHPESEHNAKPPALKLSLKRRRS 505
            ||.|                      .|........|                  .:|.|:|.:.
Mouse   227 EDPT----------------------FRCDECDELFQ------------------CRLDLRRHKK 251

  Fly   506 KSSSVSQPEKQTKVEAGGFVSSLLLQRLQSNSNVIPPAISTESQ-QVLSCAKCNLQFDFERFQEL 569
            .:.|          .||..:...|.:.|:      |..:...|. |...|..|...|.
Mouse   252 YACS----------SAGAQLYEGLGEELK------PEGLGVGSDGQAHECKDCERMFP------- 293

  Fly   570 NKHQAQCSGIQSANSSQLSQKQERFFRCSQCCSV---------HQCWHFFLHMREVHRRYICLYC 625
            ||:        |.....:...:||.::|.||...         ||..|      :..:|:.|..|
Mouse   294 NKY--------SLEQHMIVHTEEREYKCDQCPKAFNWKSNLIRHQMSH------DSGKRFECENC 344

  Fly   626 NHVYPSVEKLSLHLENKHDIDQSHFAKD---------AWDQQQSKEDRARHLVCCTCQATFVQGS 681
            ..|:.....|..|:.::|...::|...|         ...|.:......:..:|..|..::.|.|
Mouse   345 VKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFS 409

  Fly   682 EFEDH--------------DCSQLMQPCA-------LCNQKGGHIIG--------------CKNN 711
            ....|              ||.|:....:       .|..|..:..|              ....
Mouse   410 NLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGSIFTPGLPLTPSPMMDKT 474

  Fly   712 KRKPTKRRRKV-------RRPPEPPLPVSQEAVEQPVPVEAIPEQLPQQLHLQSDIQNPFP---- 765
            |..||.....:       .||....||.|......|......|...|..|:.:..:..|.|
Mouse   475 KPSPTLNHGGLGFSEYFPSRPHPGSLPFSAAPPAFPALTPGFPGIFPPSLYPRPPLLPPTPLLKS 539

  Fly   766 ----AENIPAPEPVEDPPAPPIPKLVVPKIMLRVPKEFQKSVDAALSSTDTEDEELETAQPVEEA 826
                |::...|.|:.:|..|          ::.......:...||..|.:..|..||.|. .|:.
Mouse   540 PLNHAQDAKLPSPLGNPALP----------LVSAVSNSSQGATAATGSEEKFDGRLEDAY-AEKV 593

  Fly   827 VSAPPEDLPFDAPPPPPPALSYDDSTSSKLNRVL-AELERT---------KLDIERTKA-DIITK 880
            .:..|:              ..|.|....:|... .:|:.|         .||.:|.|. |....
Mouse   594 KNRSPD--------------MSDGSDFEDINTTTGTDLDTTTGTGSDLDSDLDSDRDKGKDKGKP 644

  Fly   881 KQSKIIMANAHLENVVPQVVDPPQHLQPQQEEQRRWSLTPPASPHNNHVNLPEPPPALITEFQGQ 945
            .:||.....|.:         ||..:....|        .||. ::.|...|.|...|:|.....
Mouse   645 VESKPEFGGASV---------PPGAMNSVAE--------VPAF-YSQHSFFPPPEEQLLTASGAA 691

  Fly   946 PDAVR------RNSLGSDCMDMDDSLNAPEMEGSRDFTEAQKETLEPAPPSQDTQTADEPLA--- 1001
            .|:::      ....|...|.|.:     :..||..:.........|..|.......|..||
Mouse   692 GDSIKAIASIAEKYFGPGFMSMQE-----KKLGSLPYHSVFPFQFLPNFPHSLYPFTDRALAHNL 751

  Fly  1002 ---IQPLPPADGIMVAGPDTHTVDLQLDRPLDRFSMVDFVRLCLKSVYSLCLYCNHARRIAVNVK 1063
               .:|..|.|.:.|.||..       :.|.|
Mouse   752 LVKAEPKSPRDALKVGGPSA-------ECPFD--------------------------------- 776

  Fly  1064 QLVIHLIGQHRFTATVDSITAEELYAE-TIVAKLKSFLPNLENEYMNAASCCS----LENGKYVE 1123
                              :|.:...|: .::|.....:|:...|.....|..|    .:||...|
Mouse   777 ------------------LTTKPKEAKPALLAPKVPLIPSSGEEQPLDLSIGSRARASQNGGGRE 823

  Fly  1124 PFNERIYECFTCRFVTSTHKELYTHNRRLHIKSNITCVMCQTNFYSYSEILCHICPGEVAGSVYD 1188
            |....:|                 ..|:..:                ||.|..:||.::.... .
Mouse   824 PRKNHVY-----------------GERKPGV----------------SEGLPKVCPAQLPQQP-S 854

  Fly  1189 LQFRCCLCDMAPLPSAFRL-----MVHLRKQHQACDICLEDCQSQSKLSSHVWKHKLLHLCYRCG 1248
            |.:        ..||.|.:     .|..||......:..|.....|.|..|.....:
Mouse   855 LHY--------AKPSPFFMDPIYSRVEKRKVADPVGVLKEKYLRPSPLLFHPQMSAI-------- 903

  Fly  1249 IAYRNKQDISKHLFWKHGTES-----AGCKQCLQKRWRHVYHFCVPP------------AEFPCE 1296
                  :.:::.|      ||     |.....||....|.::|..||            ..:.|.
Mouse   904 ------ETMTEKL------ESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCR 956

  Fly  1297 QCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRKLLLKHASSHVAKELPQAVSVEQTAD 1361
            .||.:|.::..|..|.|.|||:..|.|  :.|:..|.....|.:|..:...||.|....:.....
Mouse   957 YCGKIFPRSANLTRHLRTHTGEQPYRC--KYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCF 1019

  Fly  1362 AAPTEKLEDIKEELEEGEDEKEGAHNQEKLLSESLTNNETPKKEESDRIDNSIEPPLSKSENRKR 1426
            ...|.....:|:.      |.|||...:.  |..|||:          :..|...|.|:|:|...
Mouse  1020 GQQTNLDRHLKKH------EHEGAPVSQH--SGVLTNH----------LGTSASSPTSESDNHAL 1066

  Fly  1427 RKKSKRNKESLEDLNLIAPNLSESDSSDDSDSDAPRSSHQEQPKLPMRSSVDDLDMPKVMLSPSS 1491
            ..: |.:....|..|.||.:                ..:|...::..|..:.|||.     :|..
Mouse  1067 LDE-KEDSYFSEIRNFIANS----------------EMNQASTRMDKRPEIQDLDS-----NPPC 1109

  Fly  1492 ESDADELDGKSKLEDKEEKPLDGSTEEKALDA--DDELEPKKEEDQVDVSIWKNLLQNQAVAIPE 1554
            ...|     .:|.||.||:      ||:.|:.  ||.|..|.:||.|..:             ||
Mouse  1110 PGSA-----SAKPEDVEEE------EEEELEEEDDDSLAGKSQEDTVSPT-------------PE 1150

  Fly  1555 EQAV-KDEEREDSLVNLPPAKLHVAWSDHDYCKLYR-----TPAPSPVKQKSANKSSIKTPGENA 1613
            .|.| :|||.|:      |..|.:.:.....|...|     ...|:|...|..:   ::...|.|
Mouse  1151 PQGVYEDEEDEE------PPSLTMGFDHTRRCVEERGGGLLALEPTPTFGKGLD---LRRAAEEA 1206

  Fly  1614 SSDSDSSSSSSSSD 1627
            ....|..:|:..|:
Mouse  1207 FEVKDVLNSTLDSE 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	4/15 (27%)
		C2H2 Zn finger	1295..1315	CDD:275370	7/19 (37%)
		C2H2 Zn finger	1323..1341	CDD:275370	4/17 (24%)
		PHD_ING	2110..2156	CDD:276980
Prdm16	XP_006539234.1	PR-SET_PRDM16	61..223	CDD:380990	38/217 (18%)
		C2H2 Zn finger	233..253	CDD:275368	4/37 (11%)
		zf-C2H2	283..305	CDD:333835	6/36 (17%)
		C2H2 Zn finger	285..305	CDD:275368	6/34 (18%)
		zf-H2C2_2	297..321	CDD:372612	6/23 (26%)
		zf-C2H2	311..333	CDD:333835	5/21 (24%)
		C2H2 Zn finger	313..333	CDD:275368	5/19 (26%)
		zf-C2H2	339..360	CDD:333835	5/20 (25%)
		C2H2 Zn finger	341..359	CDD:275368	5/17 (29%)
		zf-C2H2	368..390	CDD:333835	3/21 (14%)
		C2H2 Zn finger	370..390	CDD:275368	2/19 (11%)
		zf-C2H2	396..418	CDD:333835	5/21 (24%)
		C2H2 Zn finger	398..418	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..445	CDD:275368	3/17 (18%)
		zf-C2H2	953..975	CDD:333835	7/21 (33%)
		C2H2 Zn finger	955..975	CDD:275368	7/19 (37%)
		zf-H2C2_2	967..991	CDD:372612	9/25 (36%)
		zf-C2H2	981..1004	CDD:333835	6/24 (25%)
		C2H2 Zn finger	983..1004	CDD:275368	5/22 (23%)
		zf-C2H2	1010..1032	CDD:333835	2/21 (10%)
		C2H2 Zn finger	1012..1032	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100