DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and PRDM16

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_071397.3	Gene:	PRDM16 / 63976	HGNCID:	14000	Length:	1276	Species:	Homo sapiens

Alignment Length:	1674	Identity:	307/1674 - (18%)
Similarity:	469/1674 - (28%)	Gaps:	631/1674 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 QPSESLGANHESEIDEKVD------------------HFQPKESDSNEVEDKYFQSANEDSESEI 257
            :|:..|.|:|.:| ||..|                  .|.|||.                  |..
Human    23 EPNRDLLASHSAE-DEAEDSAMSPIPVGPPSPFPTSEDFTPKEG------------------SPY 68

  Fly   258 EETVYTPPVINLETDSESGDKEFISIKDNESPVLEIEGGTEKSQTSGDLYQADVGEYASTAPPEV 322
            |..||.|..|.:..|.|        ::::..|                  .|.:|.:|. ...|.
Human    69 EAPVYIPEDIPIPADFE--------LRESSIP------------------GAGLGVWAK-RKMEA 106

  Fly   323 DETTSQTIGVPSLEGSDT-LDSPSLTMDVDLPCSEDGAPPNVIKIESDMEDEAHSDSVKLKEHTV 386
            .|.....:.||.....:| .....:..||:: ..::|.   :.||..|:..|..
Human   107 GERLGPCVVVPRAAAKETDFGWEQILTDVEV-SPQEGC---ITKISEDLGSEKF----------- 156

  Fly   387 EVVPLIKLN--GAHKALK------------------EEKLEDGEVEEVEDPGEELEDPKEQSVIT 431
                .:..|  ||...||                  .|::....::::| |||||
Human   157 ----CVDANQAGAGSWLKYIRVACSCDDQNLTMCQISEQIYYKVIKDIE-PGEEL---------- 206

  Fly   432 NHTGNNTKEEDTTASQVSALPLILPVGTTRSRSISSRSSTVSSASQPHLVIDHPESEHNAKPPAL 496
                           .|.....:.|:||.                                ||.|
Human   207 ---------------LVHVKEGVYPLGTV--------------------------------PPGL 224

  Fly   497 -----------------KLSLKRRRSKSSSVSQPEKQTKVEAGGFVSSLLLQRLQSNSNVIPPAI 544
                             ||.|:|.:          |.|....|..:...|.:.|:      |..:
Human   225 DEEPTFRCDECDELFQSKLDLRRHK----------KYTCGSVGAALYEGLAEELK------PEGL 273

  Fly   545 STESQQVLSCAKCNLQFDFERFQELNKHQAQCSGIQSANSSQLSQKQERFFRCSQCCSV------ 603
            ...|.|...|..|...|.       ||:        |.....:...:||.::|.||...
Human   274 GGGSGQAHECKDCERMFP-------NKY--------SLEQHMVIHTEEREYKCDQCPKAFNWKSN 323

  Fly   604 ---HQCWHFFLHMREVHRRYICLYCNHVYPSVEKLSLHLENKHDIDQSHFAKD---------AWD 656
               ||..|      :..:|:.|..|..|:.....|..|:.::|...::|...|         ...
Human   324 LIRHQMSH------DSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLK 382

  Fly   657 QQQSKEDRARHLVCCTCQATFVQGSEFEDHDCSQLMQPCALCNQKGGHI-----IGCKN--NKRK 714
            |.:......:..:|..|..::.|.|.              ||..|..|.     |.||:  ....
Human   383 QHKHIHSTVKPFICEVCHKSYTQFSN--------------LCRHKRMHADCRTQIKCKDCGQMFS 433

  Fly   715 PTKRRRKVRRPPE------------PPLPVSQEAVEQPVPVEAIPEQLPQQLHLQSDIQNPFPAE 767
            .|....|.||..|            |.||::      |.|:....:..|...|........||:.
Human   434 TTSSLNKHRRFCEGKNHYTPGGIFAPGLPLT------PSPMMDKAKPSPSLNHASLGFNEYFPSR 492

  Fly   768 NIPAPEPVED-PPAPP---------IPKLVVPKIMLRVPKEFQKSVDAALSSTDTEDEELET--- 819
            ..|...|... ||..|         .|..:.|:..|..|....||     ....|:|.:|.:
Human   493 PHPGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPTSLLKS-----PLNHTQDAKLPSPLG 552

  Fly   820 --AQPVEEAVSAPPEDLPFDAPPPPPPALSYDDSTSSKLNRVLAELE----------RTKLDIER 872
              |.|:..|||...:.....|.|........:||...||....:::.          .|..|::.
Human   553 NPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDT 617

  Fly   873 TKADIITKKQSKIIMANAHLENVVPQVVDPPQHLQPQQEEQRRW--SLTPPASP---------HN 926
            |..            ..:.|::.|....|..:......|.|.::  .|.||.:|         ::
Human   618 TTG------------TGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYS 670

  Fly   927 NHVNLPEPPPALITEFQGQPDAVR------RNSLGSDCMDMDDSLNAPEMEGSRDFTEAQKETLE 985
            .|...|.|...|:|......|:::      ....|...|.|.:     :..||..:..|......
Human   671 QHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQE-----KKLGSLPYHSAFPFQFL 730

  Fly   986 PAPPSQDTQTADEPLA------IQPLPPADGIMVAGPDTHTVDLQLDRPLDRFSMVDFVRLCLKS 1044
            |..|.......|..||      .:|..|.|.:.|.||..       :.|.|
Human   731 PNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSA-------ECPFD-------------- 774

  Fly  1045 VYSLCLYCNHARRIAVNVKQLVIHLIGQHRFTATVDSITAEELYAETIVAKLKSFLPNL------ 1103
                                                           :..|.|...|.|
Human   775 -----------------------------------------------LTTKPKDVKPILPMPKGP 792

  Fly  1104 ------ENEYMN---AASCCSLENGKYVEPFNERIYECFTCRFVTSTHKELYTHNRRLHIKSNIT 1159
                  |.:.::   .:...:.:||...||....:|                 ..|:|
Human   793 SAPASGEEQPLDLSIGSRARASQNGGGREPRKNHVY-----------------GERKL------- 833

  Fly  1160 CVMCQTNFYSYSEILCHICPGEVAGSVYDLQFRCCLCDMAPL----PSAFRL-----MVHLRKQH 1215
                     ...|.|..:||..:.             ...||    ||.|.:     .|..||..
Human   834 ---------GAGEGLPQVCPARMP-------------QQPPLHYAKPSPFFMDPIYSRVEKRKVT 876

  Fly  1216 QACDICLEDCQSQSKLSSHVWKHKLLHLCYRCGIAYRNKQDISKHLFWKHGTES-----AGCKQC 1275
            .......|.....|.|..|.....:              :.:::.|      ||     |.....
Human   877 DPVGALKEKYLRPSPLLFHPQMSAI--------------ETMTEKL------ESFAAMKADSGSS 921

  Fly  1276 LQKRWRHVYHFCVPP------------AEFPCEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGC 1328
            ||....|.::|..||            ..:.|..||.:|.::..|..|.|.|||:..|.|  :.|
Human   922 LQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRC--KYC 984

  Fly  1329 EEKFVSRKLLLKHASSHVAKELPQAVSVEQTADAAPTEKLEDIKEELEEGEDEKEGAHNQEKLLS 1393
            :..|.....|.:|.                                        ...||:||...
Human   985 DRSFSISSNLQRHV----------------------------------------RNIHNKEKPFK 1009

  Fly  1394 ESLTNNETPKKEESDRIDNSIEPPLSKSENRKRRKKSKRNKESLEDLNLIAPNLSESDSSDDSDS 1458
            ..|.|....::...||       .|.|.|:        .|....:...::..:|..|.||..|:|
Human  1010 CHLCNRCFGQQTNLDR-------HLKKHEH--------ENAPVSQHPGVLTNHLGTSASSPTSES 1059

  Fly  1459 D--APRSSHQEQPKLPMRSSVDDLDMPKVMLSPSSESDADELDGKS--------KLEDKEEKPLD 1513
            |  |.....::.....:|:.:.:.:|.:........:|...:||.:        |.||.||:. |
Human  1060 DNHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQIVDGSAQCPGLASEKQEDVEEED-D 1123

  Fly  1514 GSTEEKALDADDELEPKKEEDQVDVSIWKNLLQNQAVAIPEEQAV-KDEEREDSLVNLPPAKLHV 1577
            ...||   |.:|.|..|.::|.|..:             ||.||. :|||.|:     |.|.|.|
Human  1124 DDLEE---DDEDSLAGKSQDDTVSPA-------------PEPQAAYEDEEDEE-----PAASLAV 1167

  Fly  1578 AW-------SDHDYCKLYRTPAPSPVKQKSANKSSIKTPGENASSDSDSSSSSSSSDS-DSSSCS 1634
            .:       .||:...|...|.|:..|.....:::     |.|....|..:|:..|:: ..:.|.
Human  1168 GFDHTRRCAEDHEGGLLALEPMPTFGKGLDLRRAA-----EEAFEVKDVLNSTLDSEALKHTLCR 1227

  Fly  1635 CGSNCSCSSSNSSSSSGNSDDSDSSTARGSPQKRSRKKSLKVK-KSSES 1682
            ...|.:.:...|.|         ..|...:|.:.|....|||. .:|||
Human  1228 QAKNQAYAMMLSLS---------EDTPLHTPSQGSLDAWLKVTGATSES 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	4/15 (27%)
		C2H2 Zn finger	1295..1315	CDD:275370	7/19 (37%)
		C2H2 Zn finger	1323..1341	CDD:275370	4/17 (24%)
		PHD_ING	2110..2156	CDD:276980
PRDM16	NP_071397.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		13/63 (21%)
		SET	84..209	CDD:214614	29/196 (15%)
		C2H2 Zn finger	283..303	CDD:275368	6/34 (18%)
		zf-H2C2_2	295..319	CDD:290200	6/23 (26%)
		C2H2 Zn finger	311..331	CDD:275368	5/19 (26%)
		zf-C2H2	337..358	CDD:278523	5/20 (25%)
		C2H2 Zn finger	339..357	CDD:275368	5/17 (29%)
		zf-C2H2	366..388	CDD:278523	3/21 (14%)
		C2H2 Zn finger	368..388	CDD:275368	2/19 (11%)
		zf-C2H2_8	369..450	CDD:292531	18/94 (19%)
		zf-C2H2	394..416	CDD:278523	7/35 (20%)
		C2H2 Zn finger	396..416	CDD:275368	7/33 (21%)
		C2H2 Zn finger	425..443	CDD:275368	4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..657		26/140 (19%)
		Interaction with CTBP1, CTBP2 and ZNF516. /evidence=ECO:0000250\|UniProtKB:A2A935	679..1038		88/554 (16%)
		Mediates interaction with SKI and regulation of TGF-beta signaling. /evidence=ECO:0000269\|PubMed:19049980	739..1276		140/756 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..804		7/92 (8%)
		COG5048	931..>1083	CDD:227381	40/208 (19%)
		zf-C2H2	951..973	CDD:278523	7/21 (33%)
		C2H2 Zn finger	953..973	CDD:275368	7/19 (37%)
		zf-H2C2_2	965..989	CDD:290200	9/25 (36%)
		zf-C2H2	979..1002	CDD:278523	6/64 (9%)
		C2H2 Zn finger	981..1002	CDD:275368	5/62 (8%)
		zf-C2H2	1008..1030	CDD:278523	5/28 (18%)
		C2H2 Zn finger	1010..1030	CDD:275368	5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1065		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1163		23/79 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100