Protein Alignment MESR4 and ING3

DIOPT Version :9

• Sequence 1: NP_001097359.1
• Gene: MESR4 / 36986
• FlyBaseID: FBgn0034240
• Length: 2171
• Species: Drosophila melanogaster
• Sequence 2: NP_061944.2
• Gene: ING3 / 54556
• HGNCID: 14587
• Length: 418
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 112/548 - (20%)
• Similarity: 159/548 - (29%)
• Gaps: 235/548 - (42%)

  Fly  1680 SESLKIDQNGQNEQNQVEDTTA---VNENNNPVAPPSPKPPMYNE------SDFDTAFSDTDE-- 1733
            :|..::|...||..:|:|...:   :|...|       ||....|      .|:..|..|.||
Human    23 TEMREMDLQVQNAMDQLEQRVSEFFMNAKKN-------KPEWREEQMASIKKDYYKALEDADEKV 80

  Fly  1734 -------EFYDSHPQKLANELLTQKREALMAEHA---------------PMRPSNNYDI-----V 1771
                   :..|.|.:||..||...|.| |.|::|               |.:|.||:..     |
Human    81 QLANQIYDLVDRHLRKLDQELAKFKME-LEADNAGITEILERRSLELDTPSQPVNNHHAHSHTPV 144

  Fly  1772 ENSR-------PSTPSLPEE-------ASAFADKREKVRNKKKKRERKSTCKSGKLQPVASTTPP 1822
            |..:       .:|..:||:       .|.......| .|....|...||..|.....|.|:
Human   145 EKRKYNPTSHHTTTDHIPEKKFKSEALLSTLTSDASK-ENTLGCRNNNSTASSNNAYNVNSS--- 205

  Fly  1823 PMDRIPGMPGMIAPLEPPTPILSHPESSLFPVT-----PLTHRQLQSSMTRMSEGSSCSDADGQL 1882
                              .|:.|:...||...|     .:...|...:..:|.||...|    .|
Human   206 ------------------QPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMKEGRRTS----SL 248

  Fly  1883 KRSKRQRRPNKF------------YGYTSDDENMSAVLAPPLQVGMQLIKPQPPPQLTWAKEDLP 1935
            |.|....:.|.|            .||:|.    ||::....|              ..:.....
Human   249 KASYEAFKNNDFQLGKEFSMARETVGYSSS----SALMTTLTQ--------------NASSSAAD 295

  Fly  1936 TPPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGSRPAKRHKPDPNDHLPPIPTLK 2000
            :...::::|||.||....|.|:...:.||...|.                            |:.
Human   296 SRSGRKSKNNNKSSSQQSSSSSSSSSLSSCSSSS----------------------------TVV 332

  Fly  2001 IRPSLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQPAPPPVLPTPLPVALPVPPPPPPAATAF 2065
            ...|...|..|.|||
Human   333 QEISQQTTVVPESDS-------------------------------------------------- 347

  Fly  2066 NQPIPPALLPNPGFATLQYFKANNIRYPIRPPAGARLAREGESVYCYCRCPYDEVS--EMIACDG 2128
            |..:.....||                              |..||.|    ::||  ||:.||.
Human   348 NSQVDWTYDPN------------------------------EPRYCIC----NQVSYGEMVGCDN 378

  Fly  2129 DNCLIEWFHFECVGIMVAPQGKWFCAEC 2156
            .:|.|||||:.|||:..||:|||:|.:|
Human   379 QDCPIEWFHYGCVGLTEAPKGKWYCPQC 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980	24/47 (51%)
ING3	NP_061944.2	ING	3..102	CDD:404028	21/85 (25%)
		TNG2	4..410	CDD:227367	112/548 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..165		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..325		9/52 (17%)
		PHD_ING3	362..406	CDD:277060	24/47 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910