DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and ich

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_001262393.1	Gene:	ich / 41069	FlyBaseID:	FBgn0286204	Length:	592	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	105/547 - (19%)
Similarity:	184/547 - (33%)	Gaps:	192/547 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1472 PMRSSVDDLDMPKVMLSP------SSESDADELDGKSKLEDKEEKPLDGSTEEKALDADDELEPK 1530
            |..|.|:.|     ::||      :|..|...|||...|       |:...:....|||.    |
  Fly     9 PSESEVESL-----LMSPCWGPPQTSAQDQYLLDGHKLL-------LEHDLDSLPSDADQ----K 57

  Fly  1531 KEEDQVDVSIWKNLLQNQAVAIPEEQAVKDEEREDSLVNLPPAKLHVAW------SDHDYCKL-- 1587
            ...|.:|     |||.|.:    ...|:.|      |..|||...:...      |.|.|..:
  Fly    58 NSLDVLD-----NLLLNGS----SLNALSD------LKPLPPFTGYTGHLSINGISGHHYHAIAQ 107

  Fly  1588 ---------YRTPAPSPVKQKSANKSSIKTPGENASSDSDSSSSSSSSDSDSSSC---------- 1633
                     |...|..|  |..:|.:|  |...|..|:|:|::|:..:...||:|
  Fly   108 RLPDESNNNYMQSAYHP--QNQSNPTS--TTQSNGGSNSNSNNSNEHNIVSSSTCLPESVLSGSG 168

  Fly  1634 -SCGSNCSC------------------------SSSNSSSSSGNSDDSDSSTARGSPQKRSRKKS 1673
             ..|.|.:|                        .:.:.|.|:.|.:.|..|.|..:|
  Fly   169 GGGGGNDACLADVKLFADSQLDSKLYSVADSCVMNGSGSGSAANGNGSGPSIATLTP-------- 225

  Fly  1674 LKVKKSSESLK-------------IDQNGQNE-----QNQVEDTTAVN----ENNNPVAPPSPKP 1716
              :.:.::||.             :|.|..::     .:.:.|||..|    ::||
  Fly   226 --IDQVADSLHNSGVRIYKDLTEYVDMNSIDDIAAIIGSAIADTTVPNQLDKDDNN--------- 279

  Fly  1717 PMYNESDFDTAFSDTDEEFYDSHPQKLANELLTQKREAL---MAEHAPMRP------------SN 1766
                  |...::.|.|.....:..|:.:.::|..::::|   :..|:|: |            |:
  Fly   280 ------DTRDSWMDLDAWIDGNCIQQESAKVLVSQQDSLGDFILPHSPL-PMHASSSTLQSLLSH 337

  Fly  1767 NY-DIVENSRPSTPSLPEEASAFADKREKVRNKKKKRERKSTCKSGKLQPVASTTPPPMDRIPGM 1830
            .| .:::|...:.|.....:.......:....|...:...||....:|....|::..|    ||
  Fly   338 GYMPLLQNRLQNGPPNGNSSGGGGGANQGAGIKGDPQAPTSTSYCNELAAATSSSCSP----PG- 397

  Fly  1831 PGMIAPLEPPTPILSHPESSLFP----VTPLTHRQ----LQSSMTRMSEGSSCS-DADG------ 1880
             .:::..:.|..::.:|.....|    .|...|:|    :|:|...:.:...|| |..|
  Fly   398 -SVVSTTDNPNGLMINPRYLSNPTNNQATGNLHQQGGYSMQASGLSLKDNGLCSPDLLGNYPHTT 461

  Fly  1881 --------------QLKRSKRQRRPNK 1893
                          :.|||:.|::.|:
  Fly   462 TASTTGSEMRTGAPKAKRSRSQKKSNQ 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980
ich	NP_001262393.1	C2H2 Zn finger	538..558	CDD:275368
		zf-H2C2_2	550..575	CDD:316026
		C2H2 Zn finger	566..586	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100