DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MESR4 and ING1

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_005528.4	Gene:	ING1 / 3621	HGNCID:	6062	Length:	422	Species:	Homo sapiens

Alignment Length:	297	Identity:	60/297 - (20%)
Similarity:	88/297 - (29%)	Gaps:	129/297 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly  1861 QLQSSMTRMSEGSSCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVLAPPLQVGMQLIKPQPPP 1925
            |:.|.|..:.|..: ...|..::..:.|:.    .|.|:.:...:....|..:...|..||.
Human   233 QIVSQMVELVENRT-RQVDSHVELFEAQQE----LGDTAGNSGKAGADRPKGEAAAQADKPN--- 289

  Fly  1926 QLTWAKEDLPTPPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGSRPAKRHKPDPN 1990
                :|..    .:|||..|..::..:|.|.:|.......|::|.        |:..||.|
Human   290 ----SKRS----RRQRNNENRENASSNHDHDDGASGTPKEKKAKT--------SKKKKRSK---- 334

  Fly  1991 DHLPPIPTLKIRPSLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQPAPPPVLPTPLPVALPVP 2055
                                        :..:.||.                      |..||:.
Human   335 ----------------------------AKAEREAS----------------------PADLPID 349

  Fly  2056 PPPPPAATAFNQPIPPALLPNPGFATLQYFKANNIRYPIRPPAGARLAREGESVYCYCRCPYDEV 2120
            |         |:|                                          .||.|.....
Human   350 P---------NEP------------------------------------------TYCLCNQVSY 363

  Fly  2121 SEMIACDGDNCLIEWFHFECVGIMVAPQGKWFCAECR 2157
            .|||.||.|.|.||||||.|||:...|:|||:|.:||
Human   364 GEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCR 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980	24/45 (53%)
ING1	NP_005528.4	ING	<189..254	CDD:289749	5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..349		25/164 (15%)
		PHD_ING1_2	355..399	CDD:277059	24/43 (56%)
		PBR. /evidence=ECO:0000250\|UniProtKB:Q9H160	405..422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910