DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and CG1602

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_610291.2	Gene:	CG1602 / 35684	FlyBaseID:	FBgn0033186	Length:	577	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	145/830 - (17%)
Similarity:	231/830 - (27%)	Gaps:	379/830 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 LSQKQERF-FRCSQC---CSVHQCWHFFLHMREVHRRYICLYCNHVYPSVEKLSLHLENKHDIDQ 647
            :|:..|:| .|||.|   ..|.|...|.||:|.||.:.
  Fly     9 VSRDYEKFLMRCSYCPTDVEVAQWQEFVLHIRNVHSKV--------------------------- 46

  Fly   648 SHFAKDAWDQQQSKEDRARHLVCCTCQATFVQGSEFEDHDCSQLMQPCALCNQKGGHIIGCKNNK 712
                       :|.||                  :||         |....:.:.||:
  Fly    47 -----------RSMED------------------DFE---------PVGENSTESGHV------- 66

  Fly   713 RKPTKRRRKVRRPPEPPLPVSQEAVEQPVPVEAIPEQLPQ------QLHLQSDIQNPFPAENIPA 771
                       .|||          |:|...|:|.:|...      |||
  Fly    67 -----------DPPE----------EKPQAEESIFQQDESADGACVQLH---------------- 94

  Fly   772 PEPVEDPPAPPIPKLVVPKIMLRVPKEFQKSVDAALSST-DTEDEELETAQPVEEAV--SAPPED 833
                                           :||..||| :||:.::......||:|  ..|.|.
  Fly    95 -------------------------------IDAVRSSTNETEESDVSLVTDEEESVQDEDPSEP 128

  Fly   834 LPFDAPPPPPPALSYDDSTSSKLNRVL---------------------------AELERTKLDIE 871
            ...||.....|...:..|...:.:|.:                           ..|:|..:|:|
  Fly   129 ALDDANLKTTPTYKFHPSFFRRDHRTIKFIEIYKEHPCLWNPAHSDYKEPKKCKEALKRMAIDLE 193

  Fly   872 RTKADIITKKQSKIIMANAHLE-NVVPQVV----DPPQ-----------HLQPQQEEQRRWSLTP 920
            .|.:..:.:...|:.:...|:: |.|.:.|    ..||           .|....:|:
  Fly   194 ATVSVFLNEMALKLAIKKVHMQFNTVHKRVVSGKQKPQSLAFSIYKLCCFLNASNDEE------- 251

  Fly   921 PASPHNNHVNLPEPPPALITEFQGQPDAVRRNSLGSDCMDMDDSLNAPEMEGS--RDFT--EAQK 981
             .:.:|..:.|               |..::|.|.:|.::|  ..|.|::..|  ::|:  .::|
  Fly   252 -GATNNEKIKL---------------DFSKKNKLTTDLIEM--YANFPQLYDSNHKEFSNMSSRK 298

  Fly   982 ETLEPAPPSQDTQTADEPLAIQPLPPADGIMVAGPDTHTVDLQLDRPLDRFSMVDFVRLCLKSVY 1046
            :..|.                         |.|......||:..|   |.|..:..:|
  Fly   299 QAYES-------------------------MAAEISVPNVDINSD---DIFRAIQNLR------- 328

  Fly  1047 SLCLYCNHARRIAVNVKQLVIHLIGQHRFTATVDSI----TAEELYAETIVAKLKSFLPNLENEY 1107
                                     |..:..|..:|    |||:.|.|..     .|:|
  Fly   329 -------------------------QWYYKNTKHAIYAGSTAEKFYLEVC-----RFMP------ 357

  Fly  1108 MNAASCCSLENGKYVEPFNERIYECFTCRFVTSTHKELYTHNRRLHIKSNI-----TCVMCQTNF 1167
                          .:.:.:|:. |..|..:||:...|.:|..:.|   ||     .|.:|..:|
  Fly   358 --------------AKMYKQRLV-CEFCHQITSSDHVLQSHIFKAH---NIGELPFKCTLCDRSF 404

  Fly  1168 YSYSEILCHICPGEVAGSVYDLQFRCCLCDMAPLPSAFRLMVHLRKQHQACDICLEDCQSQSKLS 1232
            ....|:..||                             ..||:.|.|: |..|.......|.|.
  Fly   405 VGRCELANHI-----------------------------QRVHIGKTHK-CTHCERSFAVMSDLQ 439

  Fly  1233 SHVWKH--KLLHLCYRCGIAYRNKQDISKHLFWKHGTESAGCKQCLQKRWRHVYHFCVPPAEFPC 1295
            .|:..|  ...::|..||.|:|.:..::.|:...|....|                      |.|
  Fly   440 LHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRA----------------------FKC 482

  Fly  1296 EQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRKLLLKHASSH 1345
            ..|...|.|.:.|..|.:.|.......|:.  |.:.|.|...|::|...|
  Fly   483 TMCPKDFVKKVDLSDHIKGHLNIRDKICSV--CGKGFTSCHALIRHRQIH 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	0/15 (0%)
		C2H2 Zn finger	1295..1315	CDD:275370	6/19 (32%)
		C2H2 Zn finger	1323..1341	CDD:275370	5/17 (29%)
		PHD_ING	2110..2156	CDD:276980
CG1602	NP_610291.2	GT1	157..244	CDD:304916	12/86 (14%)
		MADF_DNA_bdg	273..356	CDD:287510	23/149 (15%)
		C2H2 Zn finger	367..388	CDD:275368	6/20 (30%)
		C2H2 Zn finger	397..418	CDD:275368	6/49 (12%)
		COG5048	<423..554	CDD:227381	30/133 (23%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		zf-H2C2_2	437..460	CDD:290200	6/22 (27%)
		C2H2 Zn finger	453..470	CDD:275368	5/16 (31%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	6/21 (29%)
		C2H2 Zn finger	538..559	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100