Protein Alignment MESR4 and ing-3

DIOPT Version :10

• Sequence 1: NP_523775.2
• Gene: MESR4 / 36986
• FlyBaseID: FBgn0034240
• Length: 2171
• Species: Drosophila melanogaster
• Sequence 2: NP_496909.1
• Gene: ing-3 / 3564936
• WormBaseID: WBGene00013095
• Length: 490
• Species: Caenorhabditis elegans
• Alignment Length: 807
• Identity: 138/807 - (17%)
• Similarity: 227/807 - (28%)
• Gaps: 357/807 - (44%)

  Fly  1366 EKLEDIKEELEEGEDEKEGAHNQEKLLSESLTNNETPKKEESDRIDNSIEPPLSKSENRKRRKKS 1430
            |.|:::..||:|..||..                         ||||.:|..|:
 Worm     9 EMLDELPAELKERSDEIR-------------------------RIDNEVESRLN----------- 37

  Fly  1431 KRNKESLEDLNLIAPNLSESDSSDDSDSDAPRSSHQEQPKLPMR--SSVDDLDMPKVMLSPSSES 1493
             ||:|::.|.            .:.:..:.|....:|:.|:...  |::..|...|.:::...:
 Worm    38 -RNREAINDF------------FERTGVNMPEEQRKERCKVLQEEFSTIRVLAQRKYLIAEKMQ- 88

  Fly  1494 DADELDGKSKLEDKEEKPLDGSTEEKALDADD----ELEPKKEEDQVDVSIWKNLLQNQAVAIPE 1554
               ||..|.|:..::||    :|.:..::||:    |:..|:....|:     :||
 Worm    89 ---ELLKKYKVHLEKEK----TTFQCEMEADNSGVTEMIEKRYTQHVE-----SLL--------- 132

  Fly  1555 EQAVKDEEREDSLVNLPPAKLHVAWSDHDYCKLYRTPAPSPVKQKSANKSSIKTPGENASSDSDS 1619
             .|.|:.:|...:
 Worm   133 -TARKERKRRHRV---------------------------------------------------- 144

  Fly  1620 SSSSSSSDSDSSSCSCGSNCSCSSSNSSSSSGNSDDSDSSTARGSP--QKRSRKKSLKVKKSSES 1682
                                      .....|....|.:||....|  .|.|:.|..::.:....
 Worm   145 --------------------------GGGGGGGGSSSRASTVASGPLLSKESKDKIQRILQEGVR 183

  Fly  1683 LKIDQNGQNEQNQVEDTTAVNENNNPVAPPSPKPPMYNESDFDTAFSDTDEEFYDSHPQKLANEL 1747
            |::|.:.::.|:.:..           |.|||.|                    ...|.|:|.:.
 Worm   184 LRMDLSDESAQSALSS-----------AIPSPAP--------------------RGRPPKIAKDQ 217

  Fly  1748 LTQKREALMAEH------APMRPSNNYDIVENSRPSTPSLPEEASAFADKREKVRNKKKKRERKS 1806
            |.....|::...      .|..|:.......|:...|.|:|...|:..::.|...........:|
 Worm   218 LLLSSAAMVVASDDCLTPVPPTPTARRRSNTNALRGTVSIPSALSSMMNRGESTSRFSPNPSERS 282

  Fly  1807 TCKSGKLQPVASTTPPPMDRIPGMPGMIAPLEPPTPILSHPESSLFPVTPLTHRQLQSSMTRMSE 1871
            ...:|    :..::|.|...:         |..|| ..|.|...:.|.||:    ||:|...:||
 Worm   283 WSNAG----IDESSPTPTTSL---------LMTPT-FSSGPHIVVSPTTPV----LQNSAFVVSE 329

  Fly  1872 GSSCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVLAPPLQVGMQLIKPQPPPQLTWAKEDLPT 1936
                       .|..|.|:      .||..:.|                         .||.|
 Worm   330 -----------SRHGRTRK------LTSRVQEM-------------------------FKETL-- 350

  Fly  1937 PPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGSRPAKRHKPDPNDHLPPIPTLKI 2001
               ||.||          |.|..:|...|        ..|.....|.:|...|....|..|.
 Worm   351 ---QRQRN----------HGNSIIALQER--------MSAANLAAAAQHAHAPTSSSPQSPL--- 391

  Fly  2002 RPSLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQPAPPPVLPTPLPVALPVPPPPPPAATAFN 2066
                      |.....:..||||
 Worm   392 ----------PEIEGAAEDDDEE------------------------------------------ 404

  Fly  2067 QPIPPALLPNPGFATLQYFKANNIRYPIRPPAGARLAREGESVYCYCRCPYDEVS--EMIACDGD 2129
                     .|.:...:       .:|:..|...  ..|.|..:|:|    :|.|  :|:.||..
 Worm   405 ---------GPSYRIKR-------SHPMMAPGSE--DEEDEMHWCFC----NEKSYGDMVQCDNR 447

  Fly  2130 NCLIEWFHFECVGIMVAPQGKWFCAEC 2156
            :|.:.|||:.|:|::..|.|||:|..|
 Worm   448 HCTLRWFHYPCIGMVEPPTGKWYCPRC 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_523775.2	C2H2 Zn finger	1272..1288	CDD:275368
		zf-C2H2	1293..1315	CDD:395048
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980	18/47 (38%)
ing-3	NP_496909.1	ING	3..101	CDD:463768	27/144 (19%)
		KAR9	<194..318	CDD:430088	29/168 (17%)
		TNG2	<384..475	CDD:227367	31/168 (18%)
		PHD_ING	430..474	CDD:276980	18/47 (38%)