DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and ing-3

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_496909.1	Gene:	ing-3 / 3564936	WormBaseID:	WBGene00013095	Length:	490	Species:	Caenorhabditis elegans

Alignment Length:	807	Identity:	138/807 - (17%)
Similarity:	227/807 - (28%)	Gaps:	357/807 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly  1366 EKLEDIKEELEEGEDEKEGAHNQEKLLSESLTNNETPKKEESDRIDNSIEPPLSKSENRKRRKKS 1430
            |.|:::..||:|..||..                         ||||.:|..|:
Worm     9 EMLDELPAELKERSDEIR-------------------------RIDNEVESRLN----------- 37

  Fly  1431 KRNKESLEDLNLIAPNLSESDSSDDSDSDAPRSSHQEQPKLPMR--SSVDDLDMPKVMLSPSSES 1493
             ||:|::.|.            .:.:..:.|....:|:.|:...  |::..|...|.:::...:
Worm    38 -RNREAINDF------------FERTGVNMPEEQRKERCKVLQEEFSTIRVLAQRKYLIAEKMQ- 88

  Fly  1494 DADELDGKSKLEDKEEKPLDGSTEEKALDADD----ELEPKKEEDQVDVSIWKNLLQNQAVAIPE 1554
               ||..|.|:..::||    :|.:..::||:    |:..|:....|:     :||
Worm    89 ---ELLKKYKVHLEKEK----TTFQCEMEADNSGVTEMIEKRYTQHVE-----SLL--------- 132

  Fly  1555 EQAVKDEEREDSLVNLPPAKLHVAWSDHDYCKLYRTPAPSPVKQKSANKSSIKTPGENASSDSDS 1619
             .|.|:.:|...:
Worm   133 -TARKERKRRHRV---------------------------------------------------- 144

  Fly  1620 SSSSSSSDSDSSSCSCGSNCSCSSSNSSSSSGNSDDSDSSTARGSP--QKRSRKKSLKVKKSSES 1682
                                      .....|....|.:||....|  .|.|:.|..::.:....
Worm   145 --------------------------GGGGGGGGSSSRASTVASGPLLSKESKDKIQRILQEGVR 183

  Fly  1683 LKIDQNGQNEQNQVEDTTAVNENNNPVAPPSPKPPMYNESDFDTAFSDTDEEFYDSHPQKLANEL 1747
            |::|.:.::.|:.:..           |.|||.|                    ...|.|:|.:.
Worm   184 LRMDLSDESAQSALSS-----------AIPSPAP--------------------RGRPPKIAKDQ 217

  Fly  1748 LTQKREALMAEH------APMRPSNNYDIVENSRPSTPSLPEEASAFADKREKVRNKKKKRERKS 1806
            |.....|::...      .|..|:.......|:...|.|:|...|:..::.|...........:|
Worm   218 LLLSSAAMVVASDDCLTPVPPTPTARRRSNTNALRGTVSIPSALSSMMNRGESTSRFSPNPSERS 282

  Fly  1807 TCKSGKLQPVASTTPPPMDRIPGMPGMIAPLEPPTPILSHPESSLFPVTPLTHRQLQSSMTRMSE 1871
            ...:|    :..::|.|...:         |..|| ..|.|...:.|.||:    ||:|...:||
Worm   283 WSNAG----IDESSPTPTTSL---------LMTPT-FSSGPHIVVSPTTPV----LQNSAFVVSE 329

  Fly  1872 GSSCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVLAPPLQVGMQLIKPQPPPQLTWAKEDLPT 1936
                       .|..|.|:      .||..:.|                         .||.|
Worm   330 -----------SRHGRTRK------LTSRVQEM-------------------------FKETL-- 350

  Fly  1937 PPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGSRPAKRHKPDPNDHLPPIPTLKI 2001
               ||.||          |.|..:|...|        ..|.....|.:|...|....|..|.
Worm   351 ---QRQRN----------HGNSIIALQER--------MSAANLAAAAQHAHAPTSSSPQSPL--- 391

  Fly  2002 RPSLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQPAPPPVLPTPLPVALPVPPPPPPAATAFN 2066
                      |.....:..||||
Worm   392 ----------PEIEGAAEDDDEE------------------------------------------ 404

  Fly  2067 QPIPPALLPNPGFATLQYFKANNIRYPIRPPAGARLAREGESVYCYCRCPYDEVS--EMIACDGD 2129
                     .|.:...:       .:|:..|...  ..|.|..:|:|    :|.|  :|:.||..
Worm   405 ---------GPSYRIKR-------SHPMMAPGSE--DEEDEMHWCFC----NEKSYGDMVQCDNR 447

  Fly  2130 NCLIEWFHFECVGIMVAPQGKWFCAEC 2156
            :|.:.|||:.|:|::..|.|||:|..|
Worm   448 HCTLRWFHYPCIGMVEPPTGKWYCPRC 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980	18/47 (38%)
ing-3	NP_496909.1	ING	3..101	CDD:289749	27/144 (19%)
ing-3	NP_496909.1	PHD_ING	430..474	CDD:276980	18/47 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910