DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and ham

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster

Alignment Length:	1432	Identity:	253/1432 - (17%)
Similarity:	405/1432 - (28%)	Gaps:	595/1432 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 LQSDIQNPFPA-ENIPAPEPVEDPPAPPIPKLVVPKIMLRVPKEFQKSVDAALSSTDTEDEEL-- 817
            |...|::.|.| .::|..||||..|                |:.         ...|.:|:||
  Fly    44 LSEQIEDSFAARHHLPQQEPVEGSP----------------PRR---------DHLDIQDQELLH 83

  Fly   818 ---------ETAQPVEEAVSAPPEDLPFDAPPPPPPALSYDDSTS-----SKLNRVLAELERTK- 867
                     :..||       ||..||.........|.|.|...:     ::...:|.|..|.:
  Fly    84 HPNHFHQQNQRQQP-------PPPTLPLSVESSSAAAASVDGMDAFFKDRAQAEHILQEWVRRRE 141

  Fly   868 ----LDIERTKADIITK-------KQSKIIMANAHLENVVPQVVDPPQHLQPQQEEQRRWSLTPP 921
                ||| |....:..|       :.....|..:|..|      ||          |..|
  Fly   142 PVCELDI-RDSGGVYAKTPLQRGTRYGPFPMKLSHQPN------DP----------QLAW----- 184

  Fly   922 ASPHNNHVN-LPEPPPALITEFQGQPDAVRRNSLGSDCM---DMDDSLNAPEM--EGSRDFTEAQ 980
             ..|:.|.| ..||...:.|..:      :..|:..||:   ::...:||..:  |.:|......
  Fly   185 -KAHSRHYNGWLEPTEDVSTWLK------KIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGS 242

  Fly   981 KETLEPAPPS-----QDTQTADEPLAIQPLPPADGIMVA--------GPDTHTVDLQLDRPL--- 1029
            :..::..|.|     :|.....:.||......|..:..:        |..:...|.:.||..
  Fly   243 EMVVDGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSL 307

  Fly  1030 ---DRFSM------------VDFVRLCLKSVYSLCLYCNHARRIAVNVKQLVIHLIGQHRFTATV 1079
               |.||.            :||.    .......:.|....::..::..|..||||.|.|.
  Fly   308 YSGDEFSKDKKNSSLIREGDIDFT----DDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFK--- 365

  Fly  1080 DSITAEELYAETIVAKLKSFLPNLENEYMNAASC--CSLE--------NGKYVEPFNERIYECFT 1134
                                    ::|:    .|  |:|.        ..:.:...|.|.|.|..
  Fly   366 ------------------------QDEF----PCKQCALRFCHRPLLIKHEAISHNNIRKYSCEN 402

  Fly  1135 CRFVTSTHKELYTHNRRLHIKSNITCVMCQTNFYSYSEILCHICP--GEVAGSVYDLQFRCCLCD 1197
            |..|......|..|.|..|:.:.                 ||.||  |:..|:...|
  Fly   403 CSKVFCDPSNLQRHIRAYHVGAR-----------------CHPCPECGKTFGTSSGL-------- 442

  Fly  1198 MAPLPSAFRLMVHLRKQHQ---------ACDICLEDCQSQSKLSSHVWKHKLLHLCYRCGIAYRN 1253
                           ||||         ||::|.:.....|.|.    :||.:|
  Fly   443 ---------------KQHQHIHSSVKPFACEVCSKAYTQFSNLC----RHKRMH----------- 477

  Fly  1254 KQDISKHLFWKHGTESAGCKQCLQKRWRHVYHFCVPPAEFPCEQCGFVFSKAIYLEVHQRM--HT 1316
                            |.|:.                 :..|::|...||....|..|::.  .|
  Fly   478 ----------------ATCRM-----------------QIKCDKCNQSFSTLTSLTKHKKFCDST 509

  Fly  1317 GDFRYACTEEGCEEKFVSRKLLLKHASSHVAKELPQ-AVSVEQTADAAPTEKLEDIKEELEEGED 1380
            |...|       ..:.|:|.  .:|...|.....|. |.:...|..|.|
  Fly   510 GPGPY-------RNQHVNRH--HQHPHQHPLPHQPHLAATATSTCPAPP---------------- 549

  Fly  1381 EKEGAHNQEKLLSESLTNNETPKKE-------------------ESDRIDNSIEP---PLSKSEN 1423
             :|.:.:.....:.::....||...                   ......|.:.|   |:..|:|
  Fly   550 -RESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKN 613

  Fly  1424 RKRRKKSKRNKESLEDLNLIAPNLSESDSSDDSDSDAPRSSHQEQPKLPMRSSVDDLDMPKVMLS 1488
            ..             ||....|.::...|:.|.             |||.          ..:..
  Fly   614 PM-------------DLGCGGPEITSPVSAFDQ-------------KLPF----------GFLKG 642

  Fly  1489 PSSESDA-DELDGKS---KLEDK-EEKPL----DGSTEE--KALDADDELE----PKKEEDQVDV 1538
            .:|||.| |::..|.   |.|:| :::||    :|..:|  .:||...:||    ..|.|:|.|:
  Fly   643 ENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDM 707

  Fly  1539 SIWKNLLQNQAVAIPEEQAVKDEEREDSLVNLPPAKLHVAWSDHDYCKLYRTPAPSPVKQKSANK 1603
            .     .:.:.|:.|::|..:|:.:...:::.||                  ||.:|
  Fly   708 K-----QEPERVSTPDQQQAEDDRKSIDIMSTPP------------------PADTP-------- 741

  Fly  1604 SSIKTPGENASSDSDSSSSSSSSDSDSSSCSCGSNCSCSSSNSSSSSGNSDDS-----------D 1657
                              |......|.|.|.       ..|..|..:..::|:           :
  Fly   742 ------------------SGGDGPLDLSICR-------KRSAGSFFTAPAEDNLMLHRFMPRLHE 781

  Fly  1658 SSTARGSPQKRSRKKSLKVKKSSESLKIDQNGQNEQNQVEDTTAVNENNNPVAPPSPKPPMYNES 1722
            ....||.|        ||::||..|.   ::..::::....:.......:|...|||.||    :
  Fly   782 FEAERGQP--------LKMRKSHSSA---ESSTSQKSHKGSSPTPTPTASPGLTPSPSPP----T 831

  Fly  1723 DFDTAFSDTDEEFYDSHPQKLANELLTQKREALMAEHAPMRPSNNYDIVENSRPSTPSLPE---- 1783
            ......|.|.|          ...:.|....|..|:|:.:             .|.|:||:
  Fly   832 SAGGELSSTSE----------GGAVPTMAAAAFAADHSAL-------------ASGPTLPQTHPT 873

  Fly  1784 --------------------------------EASAFADKREKVRNK--------KKKRERKSTC 1808
                                            .|||.|.||.....|        .|.::|.| |
  Fly   874 FHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYS-C 937

  Fly  1809 K-SGKLQPVASTTPPPMDRIPGMPGMIAPLEPPTPILSHPESSLFPVTPLTHRQL---------- 1862
            | .||:.|.::.....:....|        |.|.|......:  |.::....|.:
  Fly   938 KFCGKVFPRSANLTRHLRTHTG--------EQPYPCKYCDRA--FSISSNLQRHVRNIHNKERPF 992

  Fly  1863 -----------QSSMTR-----MSEGSSCSDA-------------DGQLKRSKRQRRPNKFYGYT 1898
                       |:::.|     .|||::..|:             |...|...|...||...|..
  Fly   993 RCELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAEREEYFDDIRKFMNRVYTPNSLAGNE 1057

  Fly  1899 SDDENMSAVLAPPLQVGMQLIKPQPPPQLTWAKEDLPTPPKQRNRNNNNSSHHHHSHSNGGMAGS 1963
            .|.|..                |....|....::|      ..|.|||:|:..:::.|:|....|
  Fly  1058 GDTEEY----------------PNSDDQSVNLEKD------SGNFNNNSSNISNNNSSSGNNNNS 1100

  Fly  1964 SR 1965
            |:
  Fly  1101 SK 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	1/15 (7%)
		C2H2 Zn finger	1295..1315	CDD:275370	6/21 (29%)
		C2H2 Zn finger	1323..1341	CDD:275370	2/17 (12%)
		PHD_ING	2110..2156	CDD:276980
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	29/150 (19%)
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	3/20 (15%)
		SFP1	<391..479	CDD:227516	29/158 (18%)
		C2H2 Zn finger	400..421	CDD:275368	6/20 (30%)
		SUF4-like	403..>445	CDD:411020	14/81 (17%)
		C2H2 Zn finger	403..421	CDD:411020	5/17 (29%)
		C2H2 Zn finger	429..449	CDD:275368	9/42 (21%)
		C2H2 Zn finger	457..477	CDD:275368	6/23 (26%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	25/91 (27%)
		COG5048	935..>1028	CDD:227381	18/103 (17%)
		zf-C2H2	935..957	CDD:395048	6/22 (27%)
		C2H2 Zn finger	937..957	CDD:275368	5/19 (26%)
		zf-H2C2_2	949..973	CDD:404364	4/33 (12%)
		C2H2 Zn finger	965..986	CDD:275368	2/22 (9%)
		C2H2 Zn finger	994..1014	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100