DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and erm

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	175/992 - (17%)
Similarity:	282/992 - (28%)	Gaps:	360/992 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   724 RPPEPPLPVSQEAV----EQPVPVEAIPEQLPQQLHLQSDIQNPFPAENIPAPEPVEDPPAPPIP 784
            |..:|..|..:.|:    :.||...|..||.|.|...|.|.|:.              ..|.|:
  Fly     7 RGMQPCSPAGEIAMMPPSKSPVMESAASEQNPAQQSQQQDEQSA--------------KRACPL- 56

  Fly   785 KLVVPKIMLRVPKEFQKSVDAALSSTDTEDEELETAQPVEEAVSAPPEDLPFDAPPPPPPALSY- 848
            |..:.|||                                     .|:..|...|||.|..:|:
  Fly    57 KFSIAKIM-------------------------------------EPDHRPSQVPPPQPAPVSFA 84

  Fly   849 -DDSTSSKLNRVLAELERTKLDIERTKADIITKKQS-KIIMANAHLENVVP--------QVVDPP 903
             :|....:...:.|:.||:...||     :|:..|| ..:..::..:..||        .|..||
  Fly    85 TNDDDEDEDPEIDADSERSCSPIE-----VISLDQSPSTVNYDSAFKKYVPGPCSGATSSVASPP 144

  Fly   904 QHLQPQQEEQRRWSLTPPASPHNNHVNLPEPPP-------------------ALITEFQGQPDAV 949
            .....||....|            |..|....|                   ||..:.|....|.
  Fly   145 STAAVQQFVSSR------------HQELLSQYPLLYYAPNQLMCAAAAAQYAALTAQQQSLASAA 197

  Fly   950 RRNSLGSDCMDMDDSLNAPEMEGSRDFTEAQKETLEPAPPSQDTQTADEPLAIQPLPPADGIMVA 1014
            ..:|..:       ||||     |...:::.:..|            ..|||......|.....|
  Fly   198 HLSSFTA-------SLNA-----SLHHSQSLRRNL------------GHPLAAAAAVAAVAQSQA 238

  Fly  1015 GPD-THTVDLQLDRPLDRFSMVDFVRLCLKSVYSLCLYCNHARRIAVNVKQLVIHLIGQHRFTAT 1078
            .|: .||::   ..|:.:           ::..|..|..|..|:                |....
  Fly   239 VPNLQHTLE---KSPVAQ-----------RTAQSSGLQANLKRK----------------RSPQD 273

  Fly  1079 VDSITAEELYAETIVAKLKSFLPNLENEYMNAASCCSLENGKYVEPFNERIYECFTCRFVTSTHK 1143
            ...:|.......|.....:|..|:.:.. :..:|..|...||      .:.:.|..|..|.:.|.
  Fly   274 QGEVTPPPASTATSATGARSRSPSPQGS-IEDSSPGSASGGK------PKTFSCLECGKVFNAHY 331

  Fly  1144 ELYTHNRRLHIKSN-ITCVMCQTNFYSYSEILCHICPGEVAGSVYDLQFRCCLCDMAPLPSAFRL 1207
            .| |.:..:|..:. ..|.:|...|...|.:..|                              .
  Fly   332 NL-TRHMPVHTGARPFVCKVCGKGFRQASTLCRH------------------------------K 365

  Fly  1208 MVHLRKQHQACDICLEDCQSQSKLSSHVWKHKLLH------LCYRCGIAYRNKQDISKHLFWKHG 1266
            ::|..::...|..|.:.....|.|::    |..:|      :|..||..:..|.:...|.. .|.
  Fly   366 IIHTSEKPHKCQTCGKAFNRSSTLNT----HSRIHAGYKPFVCEYCGKGFHQKGNYKNHKL-THS 425

  Fly  1267 TESAGCKQCLQKRWRHVYHFCVPPAEFPCEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEK 1331
            .|.|                      :.|..|...|.:...|..|...|.....|.|  ..|.:.
  Fly   426 GEKA----------------------YKCNICNKAFHQVYNLTFHMHTHNDKKPYTC--RVCAKG 466

  Fly  1332 FVSRKLLLKHASSHVAKELPQAVSVEQTADAAPTEKLEDIKEELEEGE-----DEKEGAHNQEKL 1391
            |.....|.||                       ..||.:|..:|::.:     |.:.....:|.|
  Fly   467 FCRNFDLKKH-----------------------MRKLHEIGGDLDDLDMPPTYDRRREYTRREPL 508

  Fly  1392 LS--ESLTNNETPKKEESDRIDNSIEPPLSKSENRKRRKKSKRNKESLEDLNLIAPNLSESDSSD 1454
            .|  ...:...||     |....|:.||                      :|:..|.||..::|:
  Fly   509 ASGYGQASGQLTP-----DSSSGSMSPP----------------------INVTTPPLSSGETSN 546

  Fly  1455 DSDSDAPRSSHQEQPKLPMRSSVDDLDMPKVMLSPSSESDADELDGKSKLEDKEEKPLDGSTEEK 1519
            .:   .|||:..:.|.......:.        ::|..    |...|.:.|
  Fly   547 PA---WPRSAVSQYPPGGFHHQLG--------VAPPH----DYPSGSAFL--------------- 581

  Fly  1520 ALDADDELEPKKEEDQVDVSIWKNLLQNQAVAIPEEQAVKDEEREDSLVNLPPAKLHVAWSDHDY 1584
                  :|:|::                     |..|:.:..:::..|.....||:...
  Fly   582 ------QLQPQQ---------------------PHPQSQQHHQQQQRLSETFIAKVFXQ------ 613

  Fly  1585 CKLYRTPAPSPVKQKSANKSSIKTPGENASSDSDSSSSSSSSDSDSSSCS-CGSNCSCSSSNSSS 1648
             :.|.....|.....|...|::.|     ::.:.||.::|.||....... ..:..:.|||||..
  Fly   614 -RYYAESLNSSTGSTSTTSSTVTT-----TTTAISSMATSRSDLLIDXLQFVAAAAAASSSNSGQ 672

  Fly  1649 SSGNSDDSD-SSTARGS 1664
            .:|.|...: ..||.||
  Fly   673 DTGESPSPELGCTALGS 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	0/15 (0%)
		C2H2 Zn finger	1295..1315	CDD:275370	5/19 (26%)
		C2H2 Zn finger	1323..1341	CDD:275370	4/17 (24%)
		PHD_ING	2110..2156	CDD:276980
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	40/232 (17%)
		C2H2 Zn finger	320..340	CDD:275368	6/20 (30%)
		zf-H2C2_2	332..357	CDD:290200	6/25 (24%)
		zf-C2H2	346..368	CDD:278523	5/51 (10%)
		C2H2 Zn finger	348..368	CDD:275368	5/49 (10%)
		zf-H2C2_2	363..385	CDD:290200	4/51 (8%)
		C2H2 Zn finger	376..396	CDD:275368	5/23 (22%)
		zf-H2C2_2	389..413	CDD:290200	6/27 (22%)
		C2H2 Zn finger	404..424	CDD:275368	5/20 (25%)
		zf-H2C2_2	416..441	CDD:290200	7/47 (15%)
		C2H2 Zn finger	432..452	CDD:275368	5/19 (26%)
		C2H2 Zn finger	460..478	CDD:275368	6/42 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100