DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and CG32767

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_001162674.1	Gene:	CG32767 / 31430	FlyBaseID:	FBgn0052767	Length:	1281	Species:	Drosophila melanogaster

Alignment Length:	1688	Identity:	280/1688 - (16%)
Similarity:	507/1688 - (30%)	Gaps:	570/1688 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 DVGEYASTAPPEVDETTSQTIGVPSLEGSDTLDSPSLTMDV-----DLPCSEDGAPPNVIKIESD 369
            |.|...|||.|.:........||..::|...::..:|:..:     |.|..:|..|.....:...
  Fly     9 DGGSGTSTALPSLFPAVGAAAGVKDMDGLMAINDSALSQQIEFILQDAPMEQDDDPHQHTHVHHH 73

  Fly   370 MEDEAHSDSVKLKEHTVEVVPLIKLNGAHKALKEEKLEDGEVEEVEDPGEELEDPKEQSVITNHT 434
            ...:.|..|     |            :|:..:::.|:..:.:      ::...|.....:.|.:
  Fly    74 HHSQHHPHS-----H------------SHQQQQQQHLQQQQQQ------QQHHHPHHHLKLDNSS 115

  Fly   435 GNNTKEEDTTASQVSALPL------ILPVGTTRSRSISSRSSTVSSASQPHLVIDHPESEHNAKP 493
            .|:   ..|.|:..:|:.:      .....|..|.|.||.||:.:|.:..||
  Fly   116 NNH---PPTAAAAAAAVAVAATTAATAAAATNNSASFSSNSSSSNSNNSNHL------------- 164

  Fly   494 PALKLSLKRRRSKSSSVSQPEKQTKVEAGGFVSSLLLQRLQSNSNVIPPAISTESQQVLSCAKCN 558
                     ...:...:.|.::|.:            ..|.:...:|..|  |.:..||:.:...
  Fly   165 ---------DNQQQLLIQQQQQQQQ------------HHLLNGRRIIIQA--TGNSSVLAASDIK 206

  Fly   559 LQFDFERFQELNKHQAQCSGIQSANSSQLSQKQERFFRCSQCCSVHQCWHFFLHMREVHRRYICL 623
            .:.:.|...|||....| ...:.|.:::..::.|.....|
  Fly   207 EEDEEEEDPELNDENLQ-DIEEEAQAAEADEEPETTAHLS------------------------- 245

  Fly   624 YCNHVYPSVEKLSLHLENKHDIDQSHFAKDAWDQQQSKEDRARHLVCCTCQ-------------A 675
                     .::.|.||...::......:|..|.::.:..:..:.:....|             |
  Fly   246 ---------TQVKLELEEDDEMPDEEEEEDEDDDEELQHGQLEYQISAATQTAGAATSSAAGGAA 301

  Fly   676 TFVQGSEFEDHDCSQLMQPCALCNQKGGHIIGCKNNKRKPTKRRRKVRRPPEPPLPVSQEAVEQP 740
            |...||:       ||:|..|      |.|:       ..|..|..|        ||::.|:.|
  Fly   302 TAGGGSQ-------QLVQLPA------GSIV-------STTTHRLSV--------PVTEAALVQ- 337

  Fly   741 VPVEAIPEQLPQQLHLQSDIQNPFPAEN----IPAPEPVEDPPAPPIPKLVVPKIMLRVPKEFQK 801
                           ||   :.|....|    :.|.......||        ..::.|.|.....
  Fly   338 ---------------LQ---RRPVYISNAVGGLTAGATYVRMPA--------AAVISRSPMTVLN 376

  Fly   802 SVDAALSSTDTEDEELETAQPVEEAVSAPPEDLPFDAPPPPPPALSYDDSTSSKLNRVLAELERT 866
            .|..||.:|..   .|:|.|....|.:|..:.|          ||:.:.....:..:  |:.:|.
  Fly   377 VVQQALPATQL---ILQTQQQQTPAAAAAEQQL----------ALALEQQRQQQEQQ--AQQQRQ 426

  Fly   867 KLDIERTKADIITKKQSKIIMANAHLENVVPQVVDPPQHLQPQQEEQRRWSLTPPASPHNNHVNL 931
            :...:..:.....::|.:                   |..|.|||:||:           ....|
  Fly   427 QQQQQEQQRQQQQQQQQQ-------------------QQQQAQQEQQRQ-----------QQQQL 461

  Fly   932 PEPPPALITEFQGQPDAVRRNSLGSDCMDMDDSLNAPEMEGSRDFTEAQKETLEPAPPSQDTQTA 996
            .:      .:.|.|...|:.::.||...:.:.:.|:         |.:...|    |.:..|.|.
  Fly   462 QQ------QQQQQQTHPVKHSASGSSSTNNNSTTNS---------TNSNNNT----PAATATVTT 507

  Fly   997 DEPLAIQPLPPADGIMVAGPDTHTVDLQLDRPLDRFSMVDFVRLCLKSVYSLCLYCNHARRIAVN 1061
            .                                  :..|:    |::...|..|:..|....|.|
  Fly   508 S----------------------------------YQCVE----CVEKFDSKELFDIHRSGHANN 534

  Fly  1062 VKQLVIHLIGQHRFTATVDSITAEELYAETIVAKLKSFLPNLENEYMNAASCCSLENGKYVEPFN 1126
            :|..:.:::                             |.:|:|...:...|
  Fly   535 MKCAICNMV-----------------------------LKSLKNYEKHCLRC------------- 557

  Fly  1127 ERIYECFTC----RFVTSTHKELYTHNRRLHIKSNITCVMCQTNFYSYSEILCHICPGEVAGSVY 1187
             :.|||..|    ||..:..|.:..|..:...:....|.:|...|.|:.....|
  Fly   558 -KPYECQICGRVVRFRPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSFEYFKVH----------- 610

  Fly  1188 DLQFRCCLCDMAPLPSAFRLMVHLRKQHQACDIC------LEDCQSQSKLSSHVWKHKLLHLCYR 1246
                               ..:|....:..|:||      |...:..|||.|.|..||
  Fly   611 -------------------KKIHNENVNLTCEICGKVFSALASLRGHSKLHSGVKLHK------- 649

  Fly  1247 CGIAYRNKQDISKHLFWKHGTESAGCKQCLQKRWRHVYHFCVPPAEFPCEQCGFVFSKAIYLEVH 1311
                                                            |:.||..|.:...|::|
  Fly   650 ------------------------------------------------CDVCGKGFGQRYNLKIH 666

  Fly  1312 QRMHTGDFRYACTEEGCEEKFVSRKLLLKHASSHVAKELPQAVSVEQTADAAPTEKLEDIKEELE 1376
            .|.|||||.:.|  :.|::|..::..|..|...|: ::.|.|.:...||..|.:.|..:......
  Fly   667 ARTHTGDFPFEC--KICKKKLHTQSSLQTHMQVHL-RDQPGAAAAAATAAGAASSKASNSSNSSN 728

  Fly  1377 EGEDEKEGAHNQ--EKLLSESLTNNETPKKEESDRIDNSIEPPLSKSENRKRRKKSKRNKESLED 1439
            ........:.:.  ...:|.:.|.....|.|.    .:.||.|.:.|  .::.::|:.::..|:|
  Fly   729 SSNSSSSNSSSNGVSAAVSAATTTTTIVKLEP----PHEIERPGTSS--NQQLQQSQHHQMELDD 787

  Fly  1440 LNLIAPNLSESDSSDDSDSDAPRSSHQEQPKLPMRSSVDDLDMPKVMLSPSSESDADELDGKSKL 1504
            .:.::     .|..|.|......|||.........::.:|        |..|.:.:..|:..|..
  Fly   788 QSGLS-----GDEEDGSGGGMNSSSHIVNATTNRLTTGED--------SSESSNASLHLNQHSST 839

  Fly  1505 EDKEEKPLDGSTEEKALDADDELEPKKEEDQVDVS------IWKNLLQNQAVAIPEEQAVKDEER 1563
            ..........|:.::.:....: :.::.:.|..||      :.||.:|..:    ::|..:.:::
  Fly   840 SSSPASQHQVSSHQQHVHQQQQ-QQQQSQQQYLVSAPTRTIVIKNYMQQGS----QQQQQQQQQQ 899

  Fly  1564 EDSLVNLPPAKLHVAWSDHDYCKLYRTPAPSPVKQKSANKSSIKTPGENASSDSDSSSSSSSSDS 1628
            :                        .|..|:||......:|...|  .|.|.::.|::|||:|.:
  Fly   900 Q------------------------HTSDPTPVLHAQVIQSGAGT--SNGSGNTSSTNSSSNSST 938

  Fly  1629 DSSSCSCGSNCSCS------------SSNSSSSSGNS----------------DDSDSST----- 1660
            :..:.:.|.|.|..            |:.||:.||.|                ..|.|||
  Fly   939 NIVTTNAGGNLSNGSQLIRKTPIIHHSTGSSNGSGGSALTSVVQQTGVISPAQSPSSSSTSCSSS 1003

  Fly  1661 ------ARGSPQKRSRKKS--------LKVKKSSESLKIDQNGQNEQNQVEDTTAVNENNNPVAP 1711
                  |.|.|...:...:        ::..::.:..:..|....:|.|.:..|..|.:.|
  Fly  1004 TVLVSKATGVPLSIASSAAAALGGSTIIRSTRNHQQQQQQQQPAQQQQQQQRVTQRNNHRN---- 1064

  Fly  1712 PSPKPPMYNESDFDTAFSDTDEEFYDSHPQKLANELLTQKREALMAEHAPMRPSNNYDIVENSRP 1776
                    :......|..|.||:..:..||:..:...||:.....:.| ....::::|..::...
  Fly  1065 --------HHRRRHLADMDDDEDDDEDQPQQQTHTQQTQQHHHHHSHH-HNHHNHHFDDDDDDEK 1120

  Fly  1777 STPSLPEEA----------SAFADKREKVRNKKKKRERKSTCKSGKLQPVASTTPPPMDRIPGMP 1831
            |:|||...|          |...|....:..|::.....|........|     |....||....
  Fly  1121 SSPSLATAAIIKVEPNLYSSGSGDNSNDMFIKEEVMFEDSAALHSPQSP-----PSSKFRISNFD 1180

  Fly  1832 GMIAPLE-------PPTPILSHPES-------SLFPVTPLTHRQLQSSMTRMSEGSSCSDADG 1880
            ..:....       ||...|..|.|       .|:|......|...||:..:...:|.|..||
  Fly  1181 SDLVDHHVDLNHSLPPYGNLFEPHSIPDSIPVQLYPDDDDDFRLDHSSLGGLHNTTSSSTTDG 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	0/15 (0%)
		C2H2 Zn finger	1295..1315	CDD:275370	7/19 (37%)
		C2H2 Zn finger	1323..1341	CDD:275370	4/17 (24%)
		PHD_ING	2110..2156	CDD:276980
CG32767	NP_001162674.1	C2H2 Zn finger	537..557	CDD:275368	3/48 (6%)
		C2H2 Zn finger	562..582	CDD:275368	5/19 (26%)
		C2H2 Zn finger	594..614	CDD:275368	5/49 (10%)
		C2H2 Zn finger	622..642	CDD:275368	6/19 (32%)
		zf-C2H2	648..670	CDD:278523	9/76 (12%)
		C2H2 Zn finger	650..670	CDD:275368	7/19 (37%)
		zf-H2C2_2	662..684	CDD:290200	10/23 (43%)
		C2H2 Zn finger	678..698	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100