DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and Mecom

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_001376211.1	Gene:	Mecom / 294924	RGDID:	1310997	Length:	1242	Species:	Rattus norvegicus

Alignment Length:	1520	Identity:	292/1520 - (19%)
Similarity:	466/1520 - (30%)	Gaps:	540/1520 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 EGGTEKSQTSGDLYQADVGEYASTAPPEV--DETTSQTIGVPSLEGSDTL-DSPSLTMDVDLPCS 355
            :|...|..||.   :...|.|     ||:  :|       :|..|.:|.: ::|||  .:..|||
  Rat     4 KGRARKLATSN---ECAYGNY-----PEIPLEE-------MPDAEDADGIANAPSL--HIQEPCS 51

  Fly   356 ----------EDGAP-------PNVIKIESDMEDEAHSDSVKLKEHTVEVVPLIKLNGAHKAL-K 402
                      ::|:|       |:.|.|..:.|         |:|.|        :.||...: .
  Rat    52 PATSSESFTPKEGSPYKAPIYIPDDIPIPDEFE---------LREST--------MPGAGLGIWT 99

  Fly   403 EEKLEDGEVEEVEDP--GEELEDPKEQSVITNHTGNNTKEE--------DTTASQV-SALPLILP 456
            :.|:|.|   |...|  ||:..|.|:.|.     |....:|        |.:...| |.|..|..
  Rat   100 KRKIEIG---EKFGPYMGEQRSDLKDSSY-----GWEILDEFCNVKFCIDASQPDVGSWLKYIRF 156

  Fly   457 VGTTRSRSISSRS----------STVSSASQPHLVIDHPESEHNAKPPALKLSLKRR-------- 503
            .|.....::.:..          :.::...:..|.:...|..|....|.:....:.|
  Rat   157 AGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEEDPHEPMAPDIHEERQHRCEDCDQLF 221

  Fly   504 RSKSSSVSQPEK---QTKVEAGGFVSSLLLQRLQSNSNVIPPAISTESQQVLSCAKCNLQFDFER 565
            .|| :.::..:|   .|...|...|...|.|.|:|.|::      .|......|.:|:..  |..
  Rat   222 ESK-AELADHQKFPCSTPHSAFSMVEEDLQQNLESESDL------REIHGNQDCKECDRV--FPD 277

  Fly   566 FQELNKHQAQCSGIQSANSSQLSQKQERFFRCSQCCSV---------HQCWHFFLHMREVHRRYI 621
            .|.|.||             .||..:||.::|.||...         ||..|      :..:.|.
  Rat   278 LQSLEKH-------------MLSHTEEREYKCDQCPKAFNWKSNLIRHQMSH------DSGKHYE 323

  Fly   622 CLYC-NHVYPSVEKLSLHLENKHDIDQSH--------FA-KDAWDQQQSKEDRARHLVCCTCQAT 676
            |..| ..|:.....|..|:.::|...::|        || .....|.:......:..:|..|..:
  Rat   324 CENCAKQVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKS 388

  Fly   677 FVQGSEFEDH--------------DCSQLMQPCALCNQKGGHIIGC--KNNKRKPTKRRRKVRRP 725
            :.|.|....|              ||.|:....:..|:   |...|  ||:........:.:..|
  Rat   389 YTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNK---HRRFCEGKNHFAAGGFFGQGISLP 450

  Fly   726 PEPPLPVSQEAVEQPVPVEAIPEQLPQQLHLQSDIQNPFPAENIPAPEPVEDPPAP----PIPKL 786
            ..|.:..:               .:....|....:.:.|.....||  .:..|.||    ..|.|
  Rat   451 GTPAMDKT---------------SMVNMGHANPGLVDYFGTNRHPA--GLTFPTAPGFSLSFPGL 498

  Fly   787 VVPKIMLRVPKEFQKSVDAALSSTD----------TEDEELETAQPVEEAVS--------APPED 833
            ....:..|.|.....|....||||:          |..:.|...|.:.:|:|        .|.|.
  Rat   499 FPSGLYHRPPLIPASSPVKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKHPPVGDNKPVEL 563

  Fly   834 LPFDAPPPPPPALSYDDSTSSKLNRVL----AELERT-----KLDIERTK--------------- 874
            ||..:....|.....|.|.||.|:.|.    ::||.|     :.|:|..|
  Rat   564 LPERSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDLESDKEKCKENGKMFKDKVS 628

  Fly   875 -----ADIITKKQ---SKIIMANAHLENVVPQVVDPPQHLQPQQEEQRRWSLTPPASPHNNHVN- 930
                 |.|..||:   ..:..|:...:..|...|:.              |:...||....:..
  Rat   629 PLQNLASINNKKEYSNHSVFSASVEEQTAVSGAVND--------------SIKAIASIAEKYFGS 679

  Fly   931 -------------LPEPP-------PALITEFQGQPDAVRRNSLGSDCMDMDDSLNAP---EMEG 972
                         ||.|.       ||........||.              |..:.|   |.:.
  Rat   680 TGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDR--------------DLRSLPLKMEPQS 730

  Fly   973 SRDFTEAQKETLEPAPPSQDTQTADEPLAIQPLPPADGIMVAGPDTHTVDLQLDRPLDRFSMVDF 1037
            ..:..:.||.:.| :|....|:..||    :||......:.|.|.|     ..|:||| .||
  Rat   731 PSEVKKLQKGSSE-SPFDLTTKRKDE----KPLTSGSSKLPATPAT-----SQDQPLD-LSM--- 781

  Fly  1038 VRLCLKSVYSLCLYCNHARRIAVNVK---QLVIHLIGQHRFTATVDSITAEELYAETIVAKLKSF 1099
                            .:|..|...|   ....|:.|:.:.:
  Rat   782 ----------------GSRSRASGTKLTEPRKNHVFGEKKGS----------------------- 807

  Fly  1100 LPNLENEYMNAASCCSLENGKYVEPFNERIYECFTCRFVTSTH--KELYTHNRRLHIKSNITCVM 1162
              |:|.   ..:|..||::.:....|.:.||.....:......  ||.|
  Rat   808 --NMET---RPSSDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKY---------------- 851

  Fly  1163 CQTNFYSYSEILCHICPGEVAGSVYDLQFRCCLCDMAPLPSAFRLMVHLRKQHQACDICLEDCQS 1227
                          :.|.  .|.::..||        |||..       |....|.:...|..:|
  Rat   852 --------------LRPS--PGFLFHPQF--------PLPDQ-------RTWMSAIENMAEKLES 885

  Fly  1228 QSKLSSHVWKHKLLHLCYRCGIAYRNKQDISKHLFWKHGTESAGCKQCLQKRWRHVYHFCVPPAE 1292
            .|.|                      |.:.|:                |.:....::.|..||..
  Rat   886 FSGL----------------------KPEASE----------------LLQSVPSMFSFRAPPNT 912

  Fly  1293 FP------------CEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRKLLLKHASSH 1345
            .|            |..||.:|.::..|..|.|.|||:..|.|  :.|:..|.....|.:|..:.
  Rat   913 LPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRC--KYCDRSFSISSNLQRHVRNI 975

  Fly  1346 VAKELP-----------QAVSVEQ------------TADAAPTEKLEDIKEELEEGEDEKEGAHN 1387
            ..||.|           |..::::            ||.::|..:||.....|    |:||.|:.
  Rat   976 HNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESAGAIL----DDKEDAYF 1036

  Fly  1388 QE--KLLSESLTNNETPKKEESDRIDNS---IEPPLSKSENRKRRKKSKRNKESLEDLNLIAPNL 1447
            .|  ..:..|...:::|:..| :|::.|   .|..|:.|:|     ....:.|.:||..|    |
  Rat  1037 TEIRNFIGNSNHGSQSPRNME-ERMNGSHFKDEKALATSQN-----SDLLDDEEVEDEVL----L 1091

  Fly  1448 SESDSSDD-------------SDSDAPRSSHQEQPKLPM------------------------RS 1475
            .|.|..:|             .|.:.|...::|...|.|                        |.
  Rat  1092 DEEDEDNDIPGKPRKELGVTNLDEEIPEDDYEEAGALEMSCKVSPVRYKEEDYKSGLSALDHIRH 1156

  Fly  1476 SVDDLDMPKVMLSPSSESDADELDGKSKLEDKEEKPLDGSTEEKA------LDADDELEPKKEED 1534
            ..|.|.|.:  :..:..:||:...|.|.:.::.::||...::.:|      |...|.|.|.....
  Rat  1157 FTDSLKMRE--MEENQYTDAELSFGSSHVPEELKQPLHRKSKSQAYAMMLSLSDKDALHPTSHGS 1219

  Fly  1535 QVDVSIWKNLLQNQAVAIPEEQAVK 1559
            .   ::|.::    |.|..|..|::
  Rat  1220 S---NVWHSM----ARAAAESSAIQ 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	2/15 (13%)
		C2H2 Zn finger	1295..1315	CDD:275370	7/19 (37%)
		C2H2 Zn finger	1323..1341	CDD:275370	4/17 (24%)
		PHD_ING	2110..2156	CDD:276980
Mecom	NP_001376211.1	SET	50..207	CDD:394802	35/181 (19%)
		C2H2 Zn finger	214..263	CDD:275368	12/55 (22%)
		C2H2 Zn finger	268..288	CDD:275368	8/34 (24%)
		zf-H2C2_2	280..304	CDD:404364	10/36 (28%)
		zf-C2H2	294..316	CDD:395048	5/21 (24%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		C2H2 Zn finger	324..346	CDD:275368	5/21 (24%)
		SFP1	<347..399	CDD:227516	8/51 (16%)
		C2H2 Zn finger	354..374	CDD:275368	3/19 (16%)
		zf-C2H2	380..402	CDD:395048	5/21 (24%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		C2H2 Zn finger	411..429	CDD:275368	5/20 (25%)
		PHA00733	881..977	CDD:177301	27/135 (20%)
		zf-C2H2	925..947	CDD:395048	7/21 (33%)
		C2H2 Zn finger	927..947	CDD:275368	7/19 (37%)
		zf-H2C2_2	939..963	CDD:404364	9/25 (36%)
		C2H2 Zn finger	955..976	CDD:275368	5/22 (23%)
		zf-C2H2	982..1004	CDD:395048	1/21 (5%)
		C2H2 Zn finger	984..1004	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100