DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and prz1

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_593073.1	Gene:	prz1 / 2541806	PomBaseID:	SPAC4G8.13c	Length:	681	Species:	Schizosaccharomyces pombe

Alignment Length:	779	Identity:	146/779 - (18%)
Similarity:	241/779 - (30%)	Gaps:	250/779 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VLDQAKEENESHQHGQNNNAKGNEDGKPKKNDDVIDVTMANGQGFKDTPEEETTGTEETAETEET 115
            ::....:.|..|.|...:        :|.|       |.:....:...|......|....|..:|
pombe    63 LISNPSKNNIQHLHPNTS--------EPFK-------TSSKSDEYDSYPRTGNVPTFSFTELNDT 112

  Fly   116 AETEEAEQA--EESLLNSRKSTDTPVDLGANCLTTGSPSKDLVKQELVED---KSEELKE----- 170
            :.:....||  |.|:......:::|   .|..||.||.|........|.:   :.:.:.|
pombe   113 SVSGFGSQAVFENSVSPLSNPSNSP---QAFDLTQGSSSTHNANDFTVNNVGSRRQSIYEFNIGI 174

  Fly   171 PTSISLNEQFLDDIELKTEVEDKSDSLSETHMEFL-TDSEEQPSE-----SLGANHESEIDEKVD 229
            |:|...:.|||.........|....|..:....|| :.|...||.     |:||.:|::....||
pombe   175 PSSNIDSSQFLPVSRAIAASEISPSSSPQLLTSFLPSGSVSNPSSPYLQGSVGALYEADAFNFVD 239

  Fly   230 HFQPKESDSNEVEDKYFQSANEDSESEIEETVYTPPVINLETDSESGDKEFISIKDNESPVLEIE 294
            ..  .::...||:.:.|.|.:.:..|.:.|        |.:..:.:|     |..|...|
pombe   240 VM--SQASGTEVDSERFPSVDFEDPSLLME--------NQQNITGTG-----SFADYLQP----- 284

  Fly   295 GGTEKSQTSGDLYQADVGEYASTAPPEVDETTSQTIGVPSLEGSD-TLDSPSLTMDVDLPCSEDG 358
                  .:||.|     |.:.:.:|.|            |..|.| ..|:.:|...|||  ..:.
pombe   285 ------PSSGSL-----GAFTNASPGE------------SNTGIDFDTDNTNLNPSVDL--LSNH 324

  Fly   359 APPNVIKIESDMEDEAHSDSVKLKEHTVEVVPLIKLNGAHKALKEEKLEDGEVEEVEDPGEE--- 420
            :.|:.|...|...:.:|..|..|       ||     .:.:.|..|...:..:..|..|..|
pombe   325 STPSFIFENSPSAEFSHQSSPYL-------VP-----NSGRTLNSENARESTIRSVNSPFSEDHA 377

  Fly   421 -------LEDPKEQSVITNHTGNNTKEEDTTASQVSALPLILPVGTTRSRSISSRSSTVSSASQP 478
                   :.||...:.::|...|......:...|::.:|             ||.|.:.|..|.|
pombe   378 DASLTTHVFDPISPTALSNSVLNYDSNNFSGTPQINVVP-------------SSPSKSQSGPSLP 429

  Fly   479 HLVIDHPESEHNAKPPALKLSLKRRRSKSSS-VS-QPEKQTKVEAGGFVSSLLLQRLQSNSNVIP 541
                         ..|.|:..:....|:|:| || ||....        :|..||    |:|:..
pombe   430 -------------ANPLLQTDISITYSQSASPVSGQPAMNE--------NSYDLQ----NANLCA 469

  Fly   542 PAISTESQQVLSCAKCNLQFDFERFQELNKHQAQCSGIQSANSSQLSQKQERFFRCSQCCSVHQC 606
            |.:|.....                    :|::..:|.:......:.|....|...|:|.||:|.
pombe   470 PEMSPTYTA--------------------RHRSNSAGSRFDAYEPIPQLYTHFSHSSECLSVNQD 514

  Fly   607 WHF-------------FLHMREVHRR-----------------------------YICLY--CNH 627
            ...             :|.:|....|                             |:|.:  ||.
pombe   515 TELLGKIENDNSKSNDYLSVRNTRPRSRSLNSLVGNKSENSSSSKAKSESKSQGNYVCTFAGCNK 579

  Fly   628 VYPSVEKLSLHLENKH--------DIDQSHFAKDAWDQQQSKEDRARH---------LVCCTCQA 675
            .:.....|..|: |.|        .|.:..||:        :.|:.||         ..|.||..
pombe   580 RFTRAYNLKSHM-NTHTNYRPFQCSICKKSFAR--------QHDKRRHEQLHTGIKAFACVTCNQ 635

  Fly   676 TFVQGSEFEDHDCSQLMQPCALCNQKGGHIIGCKNNKRKPTKRRRKVRRPPEPPLPVSQEAVEQ 739
            .|.:......|..|::.|.|.                  .|...|.::.||.....|:..:.::
pombe   636 RFARMDALNRHYKSEVGQNCL------------------RTATERGIQVPPSRKTAVASTSKQK 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275370
		C2H2 Zn finger	1323..1341	CDD:275370
		PHD_ING	2110..2156	CDD:276980
prz1	NP_593073.1	COG5048	121..620	CDD:227381	122/625 (20%)
		zf-C2H2	570..594	CDD:278523	7/24 (29%)
		C2H2 Zn finger	577..594	CDD:275368	5/17 (29%)
		zf-H2C2_2	586..611	CDD:290200	6/25 (24%)
		C2H2 Zn finger	602..622	CDD:275368	6/27 (22%)
		zf-H2C2_2	616..639	CDD:290200	6/22 (27%)
		C2H2 Zn finger	630..648	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100