DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and Mecom

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_001347963.1	Gene:	Mecom / 14013	MGIID:	95457	Length:	1242	Species:	Mus musculus

Alignment Length:	1539	Identity:	295/1539 - (19%)
Similarity:	471/1539 - (30%)	Gaps:	524/1539 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 EGGTEKSQTSGDLYQADVGEYASTAPPEVDETTSQTIGVPSLEGSDTLDSPSLTMDVDLPCS--- 355
            :|...|..||.:....:..|......|:.|..     |:.|:        |||  .:..|||
Mouse     4 KGRARKLATSNECAYGNYPEIPLEEMPDADAD-----GITSV--------PSL--HIQEPCSPAT 53

  Fly   356 -------EDGAP-------PNVIKIESDMEDEAHSDSVKLKEHTVEVVPLIKLNGAHKAL-KEEK 405
                   ::|:|       |:.|.|..:.|         |:|.|        :.||...: .:.|
Mouse    54 SSESFTPKEGSPYKAPIYIPDDIPIPDEFE---------LREST--------MPGAGLGIWTKRK 101

  Fly   406 LEDGEVEEVEDP--GEELEDPKEQSVITNHTGNNTKEE--------DTTASQV-SALPLILPVGT 459
            :|.|   |...|  ||:..|.|:.|.     |....:|        |.:...| |.|..|...|.
Mouse   102 IEIG---EKFGPYMGEQRSDLKDSSY-----GWEILDEFCNVKFCIDASQPDVGSWLKYIRFAGC 158

  Fly   460 TRSRSISSRS----------STVSSASQPHLVIDHPESEHNAKPPALKLSLKRR--------RSK 506
            ....::.:..          :.::...:..|.:...|..|....|.:....:.|        .||
Mouse   159 YDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEEDPHEPMAPDIHEERQHRCEDCDQLFESK 223

  Fly   507 SSSVSQPEK---QTKVEAGGFVSSLLLQRLQSNSNVIPPAISTESQQVLSCAKCNLQFDFERFQE 568
             :.::..:|   .|...|...|...|.|.|:|.|::      .|......|.:|:..  |...|.
Mouse   224 -AELADHQKFPCSTPHSAFSMVEEDLQQNLESESDL------REIHGNQDCKECDRV--FPDLQS 279

  Fly   569 LNKHQAQCSGIQSANSSQLSQKQERFFRCSQCCSV---------HQCWHFFLHMREVHRRYICLY 624
            |.||             .||..:||.::|.||...         ||..|      :..:.|.|..
Mouse   280 LEKH-------------MLSHTEEREYKCDQCPKAFNWKSNLIRHQMSH------DSGKHYECEN 325

  Fly   625 C-NHVYPSVEKLSLHLENKHDIDQSH--------FA-KDAWDQQQSKEDRARHLVCCTCQATFVQ 679
            | ..|:.....|..|:.::|...::|        || .....|.:......:..:|..|..::.|
Mouse   326 CAKQVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQ 390

  Fly   680 GSEFEDH--------------DCSQLMQPCALCNQKGGHIIGC--KNNKRKPTKRRRKVRRPPEP 728
            .|....|              ||.|:....:..|:   |...|  ||:........:.:..|..|
Mouse   391 FSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNK---HRRFCEGKNHFAAGGFFGQGISLPGTP 452

  Fly   729 PLPVSQEAVEQPVPVEAIPEQLPQQLHLQSDIQNPFPAENIPAPEPVEDPPAP----PIPKLVVP 789
            .:..:               .:....|....:.:.|.....||  .:..|.||    ..|.|...
Mouse   453 AMDKT---------------SMVNMSHANPGLADYFGTNRHPA--GLTFPTAPGFSFSFPGLFPS 500

  Fly   790 KIMLRVPKEFQKSVDAALSSTD----------TEDEELETAQPVEEAVS--------APPEDLPF 836
            .:..|.|..........||||:          |..:.|...|.:.:|:|        .|.|.||.
Mouse   501 GLYHRPPLIPASPPVKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKHPPVGDNKPVELLPE 565

  Fly   837 DAPPPPPPALSYDDSTSSKLNRVL----AELERT-----KLDIERTKADIITKKQSKIIMANAHL 892
            .:....|.....|.|.||.|:.|.    ::||.|     :.|:|..|..  .|:..|:.
Mouse   566 RSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDLESDKEK--CKENGKMF------ 622

  Fly   893 ENVVPQVVDPPQHLQPQQEEQRRWSLTPPASPHNNHVNLPEPPPALITEFQGQPDAVRRNSLGSD 957
                ...|.|.|:|.         |:| ....||||...    .|.:.|......|| .:|:.:.
Mouse   623 ----KDKVSPLQNLA---------SIT-NKKEHNNHSVF----SASVEEQSAVSGAV-NDSIKAI 668

  Fly   958 CMDMDDSLNAPEMEGSRD---------------FTEAQKETLEPAPPSQDTQTADEPLAIQPLPP 1007
            ....:....:..:.|.:|               |..|..:::.|.|   |......||.::|..|
Mouse   669 ASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFP---DRDLRSLPLKMEPQSP 730

  Fly  1008 A----------------------DGIMVAGPD--THTVDLQLDRPLDRFSMVDFVRLCLKSVYSL 1048
            :                      :..:.:||.  :.|.....|:||| .||
Mouse   731 SEVKKLQKGSSESPFDLTTKRKDEKPLTSGPSKPSGTPATSQDQPLD-LSM-------------- 780

  Fly  1049 CLYCNHARRIAVNVK---QLVIHLIGQHRFTATVDSITAEELYAETIVAKLKSFLPNLENEYMNA 1110
                 .:|..|...|   ....|:.|:.:.:                         |::.   ..
Mouse   781 -----GSRGRASGTKLTEPRKNHVFGEKKGS-------------------------NMDT---RP 812

  Fly  1111 ASCCSLENGKYVEPFNERIYECFTCRFVTSTH--KELYTHNRRLHIKSNITCVMCQTNFYSYSEI 1173
            :|..||::.:....|.:.||.....:......  ||.|
Mouse   813 SSDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKY--------------------------- 850

  Fly  1174 LCHICPGEVAGSVYDLQFRCCLCDMAPLPSAFRLMVHLRKQHQACDICLEDCQSQSKLSSHVWKH 1238
               :.|.  .|.::..||        |||..       |....|.:...|..:|.|.|
Mouse   851 ---LRPS--PGFLFHPQF--------PLPDQ-------RTWMSAIENMAEKLESFSAL------- 888

  Fly  1239 KLLHLCYRCGIAYRNKQDISKHLFWKHGTESAGCKQCLQKRWRHVYHFCVPPAEFP--------- 1294
                           |.:.|:                |.:....::.|..||...|
Mouse   889 ---------------KPEASE----------------LLQSVPSMFSFRAPPNTLPENLLRKGKE 922

  Fly  1295 ---CEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRKLLLKHASSHVAKELP----- 1351
               |..||.:|.::..|..|.|.|||:..|.|  :.|:..|.....|.:|..:...||.|
Mouse   923 RYTCRYCGKIFPRSANLTRHLRTHTGEQPYRC--KYCDRSFSISSNLQRHVRNIHNKEKPFKCHL 985

  Fly  1352 ------QAVSVEQ------------TADAAPTEKLEDIKEELEEGEDEKEGAHNQE--KLLSESL 1396
                  |..::::            ||.::|..:||.....|    |:||.|:..|  ..:..|.
Mouse   986 CDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESAGAIL----DDKEDAYFTEIRNFIGNSN 1046

  Fly  1397 TNNETPKKEESDRIDNS---IEPPLSKSENRKRRKKSKRNKESLEDLNLIAPNLSESDSSDDSDS 1458
            ..:::|:..| :|::.|   .:..|:.|:|     ....:.|.:||..|:        ..:|.|:
Mouse  1047 HGSQSPRNME-ERMNGSHFKDKKALATSQN-----SDLLDDEEVEDEVLL--------DEEDEDN 1097

  Fly  1459 DAPRSSHQEQPKLPMRSSVDDLDMPKVMLSPSSESDADELDGKSKLEDKEEKPLDGSTEEKALDA 1523
            |.|.                         .|..|.....||        ||.|.|...|..||:.
Mouse  1098 DIPG-------------------------KPRKELGVTRLD--------EEIPEDDYEEAGALEM 1129

  Fly  1524 DDELEP--KKEEDQVDVSIWKNLLQNQAVAIPEEQAVKDEEREDSLVNLPPAKLHVAWSDHDYCK 1586
            ..:..|  .||||      :|:.|...........::|..|.|::           .::|.:...
Mouse  1130 SCKASPVRYKEED------YKSGLSALDHIRHFTDSLKMREMEEN-----------QYTDAELSS 1177

  Fly  1587 LYRTPAPSPVKQKSANKSSIKTPGENAS-SDSDSSSSSSSSDSD 1629
            :..:..|..:||....||..:......| ||.||...:|.|.|:
Mouse  1178 ISSSHVPEELKQTLHRKSKSQAYAMMLSLSDKDSLHPTSHSSSN 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	2/15 (13%)
		C2H2 Zn finger	1295..1315	CDD:275370	7/19 (37%)
		C2H2 Zn finger	1323..1341	CDD:275370	4/17 (24%)
		PHD_ING	2110..2156	CDD:276980
Mecom	NP_001347963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..68		13/60 (22%)
		SET	90..194	CDD:214614	21/111 (19%)
		C2H2 Zn finger	213..262	CDD:275368	12/55 (22%)
		C2H2 Zn finger	267..287	CDD:275368	8/34 (24%)
		zf-H2C2_2	279..303	CDD:316026	10/36 (28%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..345	CDD:275368	5/21 (24%)
		C2H2 Zn finger	353..373	CDD:275368	3/19 (16%)
		zf-C2H2_8	354..438	CDD:318181	16/86 (19%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		C2H2 Zn finger	410..428	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..623		20/85 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	612..625		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..824		22/150 (15%)
		CTBP-binding motif 1. /evidence=ECO:0000250	744..748		0/3 (0%)
		CTBP-binding motif 2. /evidence=ECO:0000250	775..779		3/4 (75%)
		PHA00733	880..976	CDD:177301	27/135 (20%)
		zf-C2H2	924..946	CDD:306579	7/21 (33%)
		C2H2 Zn finger	926..946	CDD:275368	7/19 (37%)
		zf-H2C2_2	938..962	CDD:316026	9/25 (36%)
		C2H2 Zn finger	954..975	CDD:275368	5/22 (23%)
		zf-H2C2_2	966..992	CDD:316026	5/25 (20%)
		C2H2 Zn finger	983..1003	CDD:275368	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1117		22/121 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100