DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and Prdm16

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	XP_038967290.1	Gene:	Prdm16 / 100366024	RGDID:	2324431	Length:	1276	Species:	Rattus norvegicus

Alignment Length:	1212	Identity:	241/1212 - (19%)
Similarity:	358/1212 - (29%)	Gaps:	405/1212 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 AISTESQQVLSCAKCNLQF------DFERFQELNKHQAQCSGIQSANSSQLSQKQERFFRCSQCC 601
            |.|.:.|.:..| :.|.|.      |.|..:||..|..:  |..|......|..::..|||.:|.
  Rat   175 ACSCDDQNLAMC-QINEQIYYKVIKDIEPGEELLVHVKE--GAYSLGVMAPSLDEDPTFRCDECD 236

  Fly   602 SVHQCWHFFLHMREVHRRYIC------LY-------------------------CNHVYPSVEKL 635
            .:.||   .|.:|. |::|.|      ||                         |..::|:...|
  Rat   237 ELFQC---RLDLRR-HKKYACSSSGAPLYEGLGEELKPEGLGGGNDGQAHECKDCERMFPNKYSL 297

  Fly   636 SLHL-----ENKHDIDQSHFA---KDAWDQQQSKEDRARHLVCCTCQATFVQGSEFEDH------ 686
            ..|:     |.::..||...|   |....:.|...|..:...|..|...|...|..:.|
  Rat   298 EQHMIVHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHV 362

  Fly   687 --------DCSQ---------------------LMQPC--------ALCNQKGGHI-----IGCK 709
                    ||.:                     :.:.|        .||..|..|.     |.||
  Rat   363 GARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCK 427

  Fly   710 N--NKRKPTKRRRKVRRPPE------------PPLPVSQEAVEQPVPVEAIPEQLPQQLHLQSDI 760
            :  .....|....|.||..|            |.||::      |.|:....:..|...|.....
  Rat   428 DCGQMFSTTSSLNKHRRFCEGKNHYTPGGLFTPGLPLT------PSPMMDKTKPSPTLNHGGLGF 486

  Fly   761 QNPFPAENIPAPEPVE-DPPA------------PPI----PKLVVPKIMLRVPKEFQKSVDAAL- 807
            ...||:...|...|.. .|||            ||.    |.|:.|..:|:.|  .....||.|
  Rat   487 SEYFPSRPHPGSLPFSAAPPAFPTLTPGFPGIFPPSLYPRPPLLPPTPLLKSP--LNHGQDAKLH 549

  Fly   808 -----------SSTDTEDEELETAQPVEEAVSAPPEDLPFDAPPPPPPALSYDDSTSSKLNRVL- 860
                       |:.....:....|...||......||...:......|.:| |.|....:|...
  Rat   550 SPLGNPALPLVSAVSNSSQGATAATGPEEKFDGRLEDSYVEKVKNRSPDMS-DGSDFEDINTTTG 613

  Fly   861 AELERT---------KLDIERTKA-DIITKKQSKIIMANAHLENVVPQVVDPPQHLQPQQEEQRR 915
            .:|:.|         .||.:|.|: |.....:||.....|.:         ||..:....|
  Rat   614 TDLDTTTGTGSDLDSDLDSDRDKSKDKGKPAESKPEFGGASV---------PPGAMNSVAE---- 665

  Fly   916 WSLTPPASPHNNHVNLPEPPPALITEFQGQPDAVR------RNSLGSDCMDMDDSLNAPEMEGSR 974
                .||. ::.|...|.|...|:|......|:::      ....|...|.|.:     :..||.
  Rat   666 ----VPAF-YSQHSFFPPPEEQLLTASGAAGDSIKAIASIAEKYFGPGFMSMQE-----KKLGSL 720

  Fly   975 DFTEAQKETLEPAPPSQDTQTADEPLA------IQPLPPADGIMVAGPDTHTVDLQLDRPLDRFS 1033
            .:.........|..|.......|..||      .:|..|.|.:.|.||..       :.|.|
  Rat   721 PYHSVFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSA-------ECPFD--- 775

  Fly  1034 MVDFVRLCLKSVYSLCLYCNHARRIAVNVKQLVIHLIGQHRFTATVDSITAEELYAETIVAKLKS 1098
                          |......|:...:..|..::...|:            |:....:|.::.:
  Rat   776 --------------LTTKPKEAKPALLTPKAPLVPSSGE------------EQPLDLSIGSRAR- 813

  Fly  1099 FLPNLENEYMNAASCCSLENGKYVEPFNERIYECFTCRFVTSTHKELYTHNRRLHIKSNITCVMC 1163
                            :.:||...||....||                 ..|:..:
  Rat   814 ----------------ASQNGGSREPRKNHIY-----------------GERKPGV--------- 836

  Fly  1164 QTNFYSYSEILCHICPGEVAGSVYDLQFRCCLCDMAPLPSAFRL-----MVHLRKQHQACDICLE 1223
                   .|.|..:||.::.... .|.:        ..||.|.:     .|..||......:..|
  Rat   837 -------GEGLPKVCPAQLPQQP-SLHY--------AKPSPFFMDPIYSRVEKRKVADPVGVLKE 885

  Fly  1224 DCQSQSKLSSHVWKHKLLHLCYRCGIAYRNKQDISKHLFWKHGTES-----AGCKQCLQKRWRHV 1283
            .....|.|..|.....:              :.:::.|      ||     |.....||....|.
  Rat   886 KYLRPSPLLFHPQMSAI--------------ETMTEKL------ESFAAMKADSGSSLQPLPHHP 930

  Fly  1284 YHFCVPP------------AEFPCEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRK 1336
            ::|..||            ..:.|..||.:|.::..|..|.|.|||:..|.|  :.|:..|....
  Rat   931 FNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRC--KYCDRSFSISS 993

  Fly  1337 LLLKHASSHVAKELPQAVSVEQTADAAPTEKLEDIKEELEEGEDEKEGAHNQEKLLSESLTNNET 1401
            .|.:|..:...||.|....:........|.....:|:.      |.|||...:.  |..|||:
  Rat   994 NLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKH------EHEGAPVSQH--SGVLTNH-- 1048

  Fly  1402 PKKEESDRIDNSIEPPLSKSENRKRRKKSKRNKESLEDLNLIAPNLSESDSSDDSDSDAPRSSHQ 1466
                    :..|...|.|:|:|.....: |.:....|..|.||.:                ..:|
  Rat  1049 --------LGTSASSPTSESDNHALLDE-KEDSYFSEIRNFIANS----------------EMNQ 1088

  Fly  1467 EQPKLPMRSSVDDLD-MPKVMLSPSSESDADELDGKSKLEDKEEKPLDGSTEEKALDA--DDELE 1528
            ...::..|..|.||| .|.   .|.|.|        :|.||.||:      ||:.|:.  ||.|.
  Rat  1089 ASTRMDKRPEVQDLDGNPP---CPGSAS--------AKQEDVEEE------EEEELEEEDDDSLA 1136

  Fly  1529 PKKEEDQVDVSIWKNLLQNQAVAIPEEQAVKDEEREDSLVNL 1570
            .|.:||.|..:             ||.|.|.::|.::...||
  Rat  1137 GKSQEDTVSPT-------------PEPQGVYEDEEDEEPPNL 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	4/15 (27%)
		C2H2 Zn finger	1295..1315	CDD:275370	7/19 (37%)
		C2H2 Zn finger	1323..1341	CDD:275370	4/17 (24%)
		PHD_ING	2110..2156	CDD:276980
Prdm16	XP_038967290.1	PR-SET_PRDM16	61..222	CDD:380990	13/49 (27%)
		C2H2 Zn finger	232..252	CDD:275368	7/23 (30%)
		zf-C2H2	282..304	CDD:395048	4/21 (19%)
		C2H2 Zn finger	284..304	CDD:275368	4/19 (21%)
		zf-H2C2_2	296..320	CDD:404364	6/23 (26%)
		zf-C2H2	310..332	CDD:395048	5/21 (24%)
		C2H2 Zn finger	312..332	CDD:275368	5/19 (26%)
		zf-C2H2	338..359	CDD:395048	5/20 (25%)
		C2H2 Zn finger	340..358	CDD:275368	5/17 (29%)
		zf-C2H2	367..389	CDD:395048	2/21 (10%)
		C2H2 Zn finger	369..389	CDD:275368	2/19 (11%)
		zf-C2H2	395..417	CDD:395048	4/21 (19%)
		C2H2 Zn finger	397..417	CDD:275368	4/19 (21%)
		C2H2 Zn finger	426..444	CDD:275368	4/17 (24%)
		zf-C2H2	952..974	CDD:395048	7/21 (33%)
		C2H2 Zn finger	954..974	CDD:275368	7/19 (37%)
		zf-H2C2_2	966..990	CDD:404364	9/25 (36%)
		SUF4-like	982..>1016	CDD:411020	8/35 (23%)
		C2H2 Zn finger	982..1008	CDD:411020	7/27 (26%)
		C2H2 Zn finger	982..1003	CDD:275368	5/22 (23%)
		zf-C2H2	1009..1031	CDD:395048	2/21 (10%)
		C2H2 Zn finger	1011..1031	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100