DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MESR4 and Taf3

DIOPT Version :9

Sequence 1:	NP_001097359.1	Gene:	MESR4 / 36986	FlyBaseID:	FBgn0034240	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_001258271.1	Gene:	Taf3 / 100360100	RGDID:	2324594	Length:	930	Species:	Rattus norvegicus

Alignment Length:	1050	Identity:	212/1050 - (20%)
Similarity:	329/1050 - (31%)	Gaps:	399/1050 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1288 VPPAEFPCEQCGFVFSKAIYLEVHQRMHTGDFRYACTEEGCEEKFVSRKLLLKHASSHVAKELPQ 1352
            :.|..||.:...|..||...|:..|.          ..:..||:           ..::...||.
  Rat    87 IEPVTFPHQIPSFPVSKNSVLQFPQP----------GSKDAEER-----------KDYIPDYLPP 130

  Fly  1353 AVS--VEQTADAAPTE---KLEDIKEELEEGED-EKEGAHNQEKLLSESLTNNETPKKEESDRID 1411
            .||  .|:..:..||:   ..|.::..|||.:: |:|...|.|..|.:...  ::|:.||
  Rat   131 IVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEVINDENFLGKRPL--DSPEVEE----- 188

  Fly  1412 NSIEPPLSKSENRKRRKKSKRN---------KESLEDLN--LIAPNLSESDSSDDSDSDAPRSSH 1465
                   ..|..|.|...||.:         :|.|..:|  .|.|.||.....|.:|...|
  Rat   189 -------MPSMKRPRLLNSKGDSLDVVLLEAREPLSSINPQKIPPMLSPVHVQDSTDLAPP---- 242

  Fly  1466 QEQPKLPMRSSVDDLDMPKVMLSPSSESDADELDGKSKL---EDKEEKPLDGSTEEKALDADDE- 1526
              .|:.|             ||:|.:         ||:|   :..|.||....|:.||.....:
  Rat   243 --SPEPP-------------MLAPFA---------KSQLPIAKPLETKPFTPKTKTKASSPGQKT 283

  Fly  1527 ------LEPKKEEDQVDVSIWKNLLQNQAVAIPEEQAVKDEEREDSLVNLPPAKLHVAWSDHDYC 1585
                  |.|.:....:          .....||:|:......:.......|....||
  Rat   284 KSPKAALSPARLGSPI----------RSPKTIPKEKKSPGRSKSPKSPKSPKIVTHV-------- 330

  Fly  1586 KLYRTPAPSPVKQKSANKS--------SIK---------TPGEN--------------------- 1612
                 |.| ||:.::.|::        ::|         ||.|.
  Rat   331 -----PQP-PVRPETPNRTPSAMVVEKTVKETIPVKPTQTPPETGKLNIEMQLKKGVVTDKTIDD 389

  Fly  1613 ----------ASSDSDSSSSSSSSDSDS-----------SSCSCGSNCSCSSSNSSSS------- 1649
                      |..:.|....||.|:|:.           |.|:. ...|.||:|.:.|
  Rat   390 SIDAVIARACAEREPDPFEFSSGSESEGDTFTSPKRISVSECTT-PKASTSSNNFTKSLATPLPL 453

  Fly  1650 SGNSDDSDSS-------------TARGSPQ----------------------------------- 1666
            ||.:..||:|             ...|:|.
  Rat   454 SGGTSSSDNSWTMDASIDEVVRKAKLGAPSNMPPTFPYISSPSISPPTPEPLHKGYEEKAKPPPS 518

  Fly  1667 ---KRSRKKSLKVKKSSESLKIDQNGQNEQN--------QVEDTTAVNENNNPVAPPSPKPPMYN 1720
               |:..||.||.|...:..:.|:..:.|:|        :|.:.....|....|..|..:.....
  Rat   519 VDVKKKLKKELKTKLKKKEKQRDRERERERNKEKSKEKDKVREREKEKEAGKEVKYPWKELMKDE 583

  Fly  1721 ESDFDTAFSDTDEEFYDSHPQ-KLANELLTQKREALMAEHAPMRPSNNYDIVENSRPSTPSLPEE 1784
            |||   .:....:||.|...: :|.:.::.::||    :|...:...                |.
  Rat   584 ESD---PYKFKIKEFEDIDAKVRLKDGIVRRERE----KHKDKKKDR----------------ER 625

  Fly  1785 ASAFADKREKVRNKKKKRERKSTCKSGKLQPVASTTPPPMDRIPGMPGMIAPLEPPTPILSHPES 1849
            .....||||:.|.|:|.||.|.     |..|.....||....:|    :.:|.....|.:....|
  Rat   626 GKREKDKRERERLKEKSREDKI-----KAPPTQLVLPPKEMALP----LFSPAAVRVPAMLPAFS 681

  Fly  1850 SLFPVTPLTHRQLQSSMTRMSEGSSCSDADGQLKRSKRQRRPNKFYGYTSDDENMSAVLAPPLQV 1914
            .:.|......::......|..        |.:.|:.|:::...|
  Rat   682 PMLPEKLFEEKEKPKEKERKK--------DKKEKKKKKEKEKEK--------------------- 717

  Fly  1915 GMQLIKPQPPPQLTWAKEDLPTPPKQRNRNNNNSSHHHHSHSNGGMAGSSRKRSKQRSLFGAGGS 1979
                           .|::.....::|.|.........|.|          ::.|...:.
  Rat   718 ---------------EKKEKEKEKEKREREKREKEKERHKH----------EKIKVEPVI----- 752

  Fly  1980 RPAKRHKPDPNDHLPPIPTLKIRPSLLPTTAPPSDSSESSSDDEEAEVNVTSVVPTPQ--PAP-- 2040
                   |.|:   |.||.|.:|              ..:..|   ::.::.|||.|:  |||
  Rat   753 -------PAPS---PVIPRLTLR--------------VGAGQD---KIVISKVVPAPEAKPAPSL 790

  Fly  2041 -----PPVLPTPLPVAL-PVPPPPPPAATAFNQPIPPALLPNPGFATLQYFKANNIRYPIRPPAG 2099
                 ||..|.|:||.: |.|.|||..|.|   .:.|||:|:|..|   ...|.:.:.|:|
  Rat   791 NRPKTPPPAPVPIPVRVSPTPLPPPLLAQA---AVCPALMPSPAPA---LSAAGSAKAPVR---- 845

  Fly  2100 ARLAREGESVYCY-------------CRCPYDEVSEMIACDGDNCLIEWFHFECVGIMVAP--QG 2149
             .:..|..|.|..             |..| |:.|.||.|  |:| .:|:|:.|||||.||  :.
  Rat   846 -SVVTETVSTYVIRDEWGNQIWICPGCNKP-DDGSPMIGC--DDC-DDWYHWPCVGIMAAPPEEM 905

  Fly  2150 KWFCAECRPK 2159
            :|||.:|..|
  Rat   906 QWFCPKCANK 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR4	NP_001097359.1	C2H2 Zn finger	1272..1288	CDD:275368	211/1049 (20%)
		C2H2 Zn finger	1295..1315	CDD:275370	5/19 (26%)
		C2H2 Zn finger	1323..1341	CDD:275370	2/17 (12%)
		PHD_ING	2110..2156	CDD:276980	22/60 (37%)
Taf3	NP_001258271.1	BTP	5..79	CDD:128846
		RSB_motif	596..>654	CDD:292910	18/82 (22%)
		PHD_TAF3	867..912	CDD:276997	21/48 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900