DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp33 and PPIG

DIOPT Version :9

Sequence 1:	NP_523773.1	Gene:	cyp33 / 36984	FlyBaseID:	FBgn0028382	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_004783.2	Gene:	PPIG / 9360	HGNCID:	14650	Length:	754	Species:	Homo sapiens

Alignment Length:	172	Identity:	94/172 - (54%)
Similarity:	113/172 - (65%)	Gaps:	9/172 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 RNPQVFFDIRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYG--------YKGCSFHRVIP 193
            :.|:.||||.|....|||:|..|.:||.|||.||||.|||.|:|.|        ||.|.||||:.
Human     6 QRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVK 70

  Fly   194 EFMCQGGDFTNNNGTGGKSIYGKKFNDENFNLKHNSFGTLSMANSGANTNGSQFFICTTKTDWLD 258
            :||.|||||:..||.||:||||..|.||:|.:|||....|||||.|.:||||||||.|..|..||
Human    71 DFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLD 135

  Fly   259 NKHVVFGHVISGAEVVRKMERCGSKSGT-PSQKIVIYSCGEL 299
            ..|||||.||||.||||::|...:.:.: |..::.|.|||||
Human   136 GHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGEL 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp33	NP_523773.1	RRM_PPIE	8..80	CDD:240793
cyp33	NP_523773.1	cyclophilin_ABH_like	139..297	CDD:238907	90/166 (54%)
PPIG	NP_004783.2	cyclophilin	8..175	CDD:412213	90/166 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..754
		PTZ00121	<392..752	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810