DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp33 and PPIL2

DIOPT Version :9

Sequence 1:	NP_523773.1	Gene:	cyp33 / 36984	FlyBaseID:	FBgn0028382	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	XP_011528343.1	Gene:	PPIL2 / 23759	HGNCID:	9261	Length:	616	Species:	Homo sapiens

Alignment Length:	306	Identity:	92/306 - (30%)
Similarity:	133/306 - (43%)	Gaps:	66/306 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PFG--DIADIQMPADYESQRHRGFAFI----------EYEQSEDAAAAIDNMNDSELCGRTIRVN 80
            ||.  ||..:|.|.:.:......|..:          |.:..:|.:..:.|.|
Human   149 PFSRQDIITLQDPTNLDKFNVSNFYHVKNNMKIIDPDEEKAKQDPSYYLKNTN------------ 201

  Fly    81 LAKPVRVKEDSFKPIWADDDWLQKHAGATLQPEGEPEAEKVE-------------TPSTGPAVIE 132
             |:.....::.:|....|:     ...||::   .||.:||:             ...|..|::.
Human   202 -AETRETLQELYKEFKGDE-----ILAATMK---APEKKKVDKLNAAHYSTGKVSASFTSTAMVP 257

  Fly   133 KAEKRNPQVFFD------------IRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYGYKG 185
            :.......:..|            :|:..| .|.:.:.|..|:.|||.|||.:||   :.:.|.|
Human   258 ETTHEAAAIDEDVLRYQFVKKKGYVRLHTN-KGDLNLELHCDLTPKTCENFIRLC---KKHYYDG 318

  Fly   186 CSFHRVIPEFMCQGGDFTNNNGTGGKSIYGKKFNDE-NFNLKHNSFGTLSMANSGANTNGSQFFI 249
            ..|||.|..|:.||||.| ..||||:|.:||.|.|| ..||.|...|.|||||||.|:|.|||||
Human   319 TIFHRSIRNFVIQGGDPT-GTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFI 382

  Fly   250 CTTKTDWLDNKHVVFGHVISGAEVVRKMERCGS--KSGTPSQKIVI 293
            ......:||.||.:||.|:.|.:|:..||...|  |:..|.::|.|
Human   383 TFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp33	NP_523773.1	RRM_PPIE	8..80	CDD:240793	11/63 (17%)
cyp33	NP_523773.1	cyclophilin_ABH_like	139..297	CDD:238907	70/170 (41%)
PPIL2	XP_011528343.1	RING-Ubox_PPIL2	38..110	CDD:319577
		RING_Ubox	100..159	CDD:388418	4/9 (44%)
		U-box domain, a modified RING finger	103..146	CDD:319361
		cyclophilin_RING	281..440	CDD:238904	69/153 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810