Protein Alignment cyp33 and Ranbp2

DIOPT Version :10

• Sequence 1: NP_523773.1
• Gene: cyp33 / 36984
• FlyBaseID: FBgn0028382
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_035370.2
• Gene: Ranbp2 / 19386
• MGIID: 894323
• Length: 3053
• Species: Mus musculus
• Alignment Length: 244
• Identity: 108/244 - (44%)
• Similarity: 141/244 - (57%)
• Gaps: 40/244 - (16%)

  Fly    83 KPVRVKEDSFKPIWADDDWLQKHAGATLQPEGEPEAE---------------------------K 120
            ||:.|..::.  :|...|:          .:||.:.|                           |
Mouse  2823 KPLNVSNNAL--VWTASDY----------ADGEAKVEQLAVRFKTKEMTESFKKKFEECQQNIIK 2875

  Fly   121 VETPSTGPAVIEKAEKRNPQVFFDIRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYGYKG 185
            ::...|..|. |.::..||.||||:...|...|||:|.|.:::||:||||||.|||.|:|:|:|.
Mouse  2876 LQNGHTSLAA-ELSKDTNPVVFFDVCADGEPLGRIIMELFSNIVPQTAENFRALCTGEKGFGFKN 2939

  Fly   186 CSFHRVIPEFMCQGGDFTNNNGTGGKSIYGKKFNDENFNLKHNSFGTLSMANSGANTNGSQFFIC 250
            ..||||:|:|:|||||.|..|||||:||||.||:||||:|||...|.|||||.|.|||.|||||.
Mouse  2940 SIFHRVVPDFICQGGDITKYNGTGGQSIYGDKFDDENFDLKHTGPGLLSMANYGQNTNSSQFFIT 3004

  Fly   251 TTKTDWLDNKHVVFGHVISGAEVVRKMERCGSKSGTPSQKIVIYSCGEL 299
            ..|.:.||.||||||.|..|.:.|||:|..||..|:.|::|.|..||:|
Mouse  3005 LKKAEHLDFKHVVFGFVKDGMDTVRKIESFGSPKGSVSRRICITECGQL 3053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyp33	NP_523773.1	RRM_PPIE	8..82	CDD:409783
		cyclophilin_ABH_like	139..297	CDD:238907	92/157 (59%)
Ranbp2	NP_035370.2	TPR 1	26..59
		LapB	<33..221	CDD:442196
		TPR repeat	59..89	CDD:276809
		TPR 2	60..93
		TPR 3	94..128
		TPR 4	165..201
		TPR 5	288..319
		TPR 6	583..616
		TPR 7	648..681
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	773..802
		20 X 2 AA repeats of F-G. /evidence=ECO:0000305	1000..3035		99/224 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1171
		RanBD1_RanBP2-like	1180..1296	CDD:270203
		zf-RanBP	1345..1374	CDD:395516
		RanBP2-type Zn finger	1350..1369	CDD:275375
		zf-RanBP	1410..1438	CDD:395516
		RanBP2-type Zn finger	1414..1433	CDD:275375
		zf-RanBP	1469..1498	CDD:395516
		RanBP2-type Zn finger	1473..1492	CDD:275375
		zf-RanBP	1499..1524	CDD:395516
		RanBP2-type Zn finger	1502..1521	CDD:275375
		zf-RanBP	1558..1587	CDD:395516
		RanBP2-type Zn finger	1562..1581	CDD:275375
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1587..1609
		zf-RanBP	1617..1645	CDD:395516
		RanBP2-type Zn finger	1621..1640	CDD:275375
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1648..1675
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1744..1772
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1819..1846
		RanBD2_RanBP2-like	1864..1980	CDD:269998
		Interaction with BICD2. /evidence=ECO:0000250|UniProtKB:P49792	1984..2124
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2030..2060
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2111..2144
		RanBD3_RanBP2-like	2161..2277	CDD:270204
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2316..2348
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2394..2430
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2443..2463
		IR1-M	2468..2530	CDD:463488
		Interaction with sumoylated RANGAP1. /evidence=ECO:0000250	2468..2472
		2 X 50 AA approximate repeats	2470..2596
		Required for E3 SUMO-ligase activity. /evidence=ECO:0000250	2470..2545
		Interaction with UBE2I. /evidence=ECO:0000250	2470..2522
		Interaction with SUMO1. /evidence=ECO:0000250	2523..2596
		IR1-M	2544..2604	CDD:463488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2598..2666
		RanBD4_RanBP2-like	2754..2870	CDD:269999	8/58 (14%)
		cyclophilin_ABH_like	2893..3051	CDD:238907	92/157 (59%)