DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp33 and CWC27

DIOPT Version :9

Sequence 1:	NP_523773.1	Gene:	cyp33 / 36984	FlyBaseID:	FBgn0028382	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_005860.2	Gene:	CWC27 / 10283	HGNCID:	10664	Length:	472	Species:	Homo sapiens

Alignment Length:	147	Identity:	58/147 - (39%)
Similarity:	79/147 - (53%)	Gaps:	22/147 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 ETPSTGPAVIEKAEKRNPQVFFDIRIGGNDAGRIVMLLRADVVPKTAENFRQLCTHEQGYGYKGC 186
            |.|:.|..:::                 ..||.|.:.|.:...||...||.|||.  :.| |...
Human     8 EPPTNGKVLLK-----------------TTAGDIDIELWSKEAPKACRNFIQLCL--EAY-YDNT 52

  Fly   187 SFHRVIPEFMCQGGDFTNNNGTGGKSIYGKKFNDE-NFNLKHNSFGTLSMANSGANTNGSQFFIC 250
            .||||:|.|:.||||.| ..|:||:||||..|.|| :..|:.|..|.::|||:|::.||||||..
Human    53 IFHRVVPGFIVQGGDPT-GTGSGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFT 116

  Fly   251 TTKTDWLDNKHVVFGHV 267
            ..:.|.|:|||.:||.|
Human   117 LGRADELNNKHTIFGKV 133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp33	NP_523773.1	RRM_PPIE	8..80	CDD:240793
cyp33	NP_523773.1	cyclophilin_ABH_like	139..297	CDD:238907	55/130 (42%)
CWC27	NP_005860.2	cyclophilin_CeCYP16-like	8..178	CDD:238906	58/147 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..386
		DUF5401	<302..>472	CDD:375164
		CWC27_CTD	376..428	CDD:412084
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900