Protein Alignment Cc2d2a and Cc2d2b

DIOPT Version :10

• Sequence 1: NP_611229.2
• Gene: Cc2d2a / 36982
• FlyBaseID: FBgn0263113
• Length: 1336
• Species: Drosophila melanogaster
• Sequence 2: XP_011245721.2
• Gene: Cc2d2b / 668310
• MGIID: 3645359
• Length: 1470
• Species: Mus musculus
• Alignment Length: 1589
• Identity: 341/1589 - (21%)
• Similarity: 600/1589 - (37%)
• Gaps: 405/1589 - (25%)

  Fly     2 EAALSRKTAKKKRK--THTTRGYRKREQEVQKLIRATEGRISGPE----------HDMEAL---S 51
            |..:.|..:|::.:  |.|.||   :.:|..|..:.::|..|..|          ...|.|   .
Mouse    24 EEMVDRHLSKEENRNITETLRG---KVREKLKNAKISQGEKSSAEPLTDTKTYRWSKTEVLLDEG 85

  Fly    52 LQFFHGFEGE-----MQQENDFAVEDCQESDEDSGG---ELAEEPTDSPSQTFIHIDLHDPPLA- 107
            |.||. ..||     .|......|.:.......|||   ..||.|.:...:..|..||.:...|
Mouse    86 LSFFI-LSGEEDSAVSQSSQQKTVSESYSKQSASGGGFRNTAEGPDEDFMEEVILTDLFEVKAAD 149

  Fly   108 ----WGQLFKQRHYYDESLLYRPSNTLHFQLHLSDLSELKDSQIRMLNRYQEQSKSKSGKLGSDL 168
                ..|:.||     |:.::.||:        |.::..:.....||.|..|..
Mouse   150 YEDDQEQIKKQ-----EANIFVPSS--------SPVASQQKLPKGMLPRILEDE----------- 190

  Fly   169 IGQLSGQKPASFLMGKHLYRSVCHR---RFQSV-----FFPPMPPSELKGLPS--------RRCL 217
             |....:||.:       |:.:|::   |..|:     :|.  ...|:..|||        |.|:
Mouse   191 -GLYVQKKPET-------YKKICNKMENRLLSLQEGKCWFE--ESGEIMSLPSPIRPSWNYRLCM 245

  Fly   218 K---------------------LCLKQ-----------------LRFSLHPQLLEEHRLAQQLED 244
            .                     .|.:.                 |:||.||...:||.|..:|..
Mouse   246 SKESLNPALKTIHRKAVKSDVGCCFRDRMDGQREMYQLDLNIVGLQFSHHPLFSQEHVLCARLLR 310

  Fly   245 LFDVYSQQRKQRICRKLREELEIARQVALKLLA---SAGQDQTAEVK---RQLKLTRQLRQRYYA 303
            |.:....:::|.:.:.|.|:|. |.:.|.||::   ...|..|..::   ||:..|:||   |.|
Mouse   311 LCESLQDRQRQSVSQLLYEKLR-ALKDATKLISKNPELSQFTTKSLQDYYRQISDTKQL---YEA 371

  Fly   304 ESAAQRNLLQRLLKEWAKLKELRRQQRFQCTRFQL-------GLRVVHPPDLEASYCAWKESFET 361
            |.....:||..:|:.|.::|.||::|.|..|..::       .||.:...:.|| ..:|
Mouse   372 EREKDHSLLHSVLQTWKQIKSLRQKQGFTSTPVKVQFHSIFHSLRALTSSENEA-ITSW------ 429

  Fly   362 DLAEVYREHLELF---------YTRLRLWTDQKSHSRTATGHSKPPRKPQFDRIMASLRKEYDKT 417
               .|...|:...         :.:...|.:|..     .|.|:.|.....:..:.:  ::.::|
Mouse   430 ---FVITPHVFWIGLVSLGTAPWVKTNTWDEQNQ-----AGVSEGPGDGSGETPLQN--EDTEET 484

  Fly   418 F----KDPEEPYVEVFR---------------------LHADEATARLSIPGGDQLPKARNYFLK 457
            .    .|||...||..:                     |:..:..|::         :...||:|
Mouse   485 LSHPASDPEGTEVEKTKPITLVPQLSFTAELTNLSKCSLYEQKRRAKM---------QKLKYFIK 540

  Fly   458 IFLDGQFVGQSRTYRLEPDLQISINECIGVLLERSLPENLNIWLYEKSTLTPKSRRLAQISTPLV 522
            ||.:.:.|.::....|:.|.::...:...:.| ...||.:.:.:||   ::.:|..|.::..||.
Mouse   541 IFYNNKQVSRTSVSPLQFDFKVMFQQIFNIQL-IYWPETICLEVYE---VSKRSTLLVKLYLPLP 601

  Fly   523 LSSKDDAVQEKLSFQALSSTQLAGDVYL-YYEYRSTE-------GWGSAL-----HLDDVQ---- 570
                             :.|:|.|...| |.|:.|.:       |.||.:     ..:|.:
Mouse   602 -----------------NKTELKGKTVLEYTEFSSDKLVIPMDGGVGSNVPFNLKESEDEELCLL 649

  Fly   571 -------RLPDALRQTLLP-----QSL----------------PALP----------QASKELVT 597
                   .|..||.:..:|     |||                |.||          .|....:.
Mouse   650 TSGKLSYSLSWALDENGIPLTPVSQSLSSAYCSVLRNVDARGVPGLPWIVNSQKLCEWADDARID 714

  Fly   598 PRPPSG----------RIKKSQLPSLIFAEQ---QLQFCGLDVLLDNRRFQLLHSRHQQRNLHTK 649
            |..|..          |.|..::|.....||   :..|...:.:..::|||||..|:..: |...
Mouse   715 PHNPDYSDITEHIMCLRHKGQEIPKYFRLEQLQDEFNFVSEEEMERSKRFQLLQLRNAGQ-LDLF 778

  Fly   650 QLRFVPALEQEI------------SEEEPLPDGRGTVQLLEPGTYWNPIDLHKHRGRKFLQLLYE 702
            .|:.:|..:.||            .::.|:.|             .|.|...:.....||:.:..
Mouse   779 LLQPMPLYDNEIPDIVFQEYESQAQKDIPISD-------------VNSITAQRINSVNFLKKVRR 830

  Fly   703 VIASQSARRAKALQTPLPLLLLAEDSDRSSGTGWTALWRAFCSVFQGQRNSLP-REPSGWSGHQS 766
            :|..:..:..|     ..|..:..|.:....|  :.|..|.|...:.:|...| |:.......||
Mouse   831 LIMKRIVKVNK-----FNLSDIVADYEEIVST--SQLTDAICKFIEPRRKLKPQRKERRKVTAQS 888

  Fly   767 APDLFKSFCVSLHVVRATGVPVRS-----------------RHILNLNERRSSAGGDMSTSLFVT 814
            ..|  ....:.:.::||..:|.|.                 .|:.|.|..:.....::
Mouse   889 ISD--GDMKILVRILRAYNIPTRKTVSYRTLSMPTHLRSSMSHLRNQNAAKLVPSNEV------- 944

  Fly   815 QTLMYSNVRPFVTLSYGQRLCRSRTAEGSNPTWNEQLQLQIQSQFGD--------LRDDLKISLF 871
              :....|.||:.:|:...:.::..|.||:|.|||::::...|...|        ::|::.|::|
Mouse   945 --INEDTVHPFIEVSFQHTVYQTNIANGSHPCWNEEIKVDFISPGHDYSFSSLSKIKDNIHINIF 1007

  Fly   872 DELIEQQYSD---EASDVYQRVQCNWLGEFRVPINSLLASRTFEGCIELAMPKVLVGYKRPLIDS 933
            ||::.:::.|   ::...:..:|.||||....|.::||......|..::.:|.:|:||..    |
Mouse  1008 DEVVIEKHEDHCLKSCSAHSYIQKNWLGSISFPFSALLQQPEISGTFQVNIPPILLGYTW----S 1068

  Fly   934 VTNMP-----TDQYPEFKEAVHLWFYLSIEPGGGDLAPLHSCALACAEKPELQQYLDE-RRLELQ 992
            .|.:|     :.|.|  ||...|..:.:|||.          .......|::.::.|: ..|:..
Mouse  1069 NTYVPPREDCSGQNP--KECTFLNIFATIEPQ----------ISYVTYNPKVDEFSDQIDILQRA 1121

  Fly   993 QLLPQ------PQRYVEPLVCTAQGKRVCLTR----LMDPVPLPPAAVPSGENPLEICIRYVSLL 1047
            |...:      |.|.|...|...:|..:.:||    |..|..|....:......|::..|:|||:
Mouse  1122 QTFTRNCKAMFPNRRVVATVFNGEGMHILVTRYIKALNPPQQLLDIFLHDSNATLDLIARFVSLI 1186

  Fly  1048 SH-LRSYDPCQGFRGVWLDNQSLLDSTWCSVKDLGVLLCNYMLSLGLECWLILGVSCPHGECSFV 1111
            .. ..:.|...| ..:|:.::..:.....:.::..:||||:.|..|.:..:.||.|...|..::|
Mouse  1187 PFAAETLDENDG-SDIWMTSECCISLAIGNKEEHAILLCNFFLYFGKKALVTLGTSVLEGHVAYV 1250

  Fly  1112 LFRQPETAELFLVSPATGKRYQLQDVHCPLRRIYCVVGKQNIYFNIQTETRVSMTHFNLQDGACW 1176
            |.:  ||.|..|.:|:||:.::..|..|||:.:.|:...:|::||||.........|:....:.|
Mouse  1251 LTQ--ETDECLLWNPSTGQCHKQFDPFCPLQSVDCLFNDKNVWFNIQQNNTPMAVQFDYSKESFW 1313

  Fly  1177 FPLFRRRVPAPQS-GVQKLDYAYKRSYE--LSQLQKHIERKIMKKISAWRTTRKTIWNRAFQPRL 1238
            ..|..:.|...:: .||..:..|..:.:  :..|:..|||.:..|:..||....|.|||.....|
Mouse  1314 KQLLPKNVQGTKAQSVQPEEIVYSDTNKSMVEDLKSRIERALKCKMMEWRPKHPTRWNRQCTSVL 1378

  Fly  1239 HKILCDMEDLSTFSRGRYDEPIFSE-QLEREFPNYRLYGFTLNFAYTNLAAISERIRTSCIHYNH 1302
            .:||..:|    |..|.:..  |.: .|||....|.:.||.:...||::.|:.:.:..:.:|.:.
Mouse  1379 RQILPKLE----FYPGSFAS--FEDSDLERLLQFYWVTGFPIQMPYTDVQAVIDAVYQTGLHASE 1437

  Fly  1303 DASVEFCVAVHLHAHANDVLSVWLFLLSM 1331
            ....||.:||::|.:.|::||||::|.|:
Mouse  1438 FPQTEFALAVYIHPYPNNILSVWVYLASL 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cc2d2a	NP_611229.2	COG4913	<231..>352	CDD:443941	37/133 (28%)
		CC2D2AN-C2	421..>545	CDD:464780	24/144 (17%)
		C2	<824..917	CDD:425499	27/103 (26%)
Cc2d2b	XP_011245721.2	DUF5523	19..260	CDD:465443	56/273 (21%)
		CC2D2AN-C2	504..671	CDD:464780	34/196 (17%)
		C2	946..>979	CDD:472691	11/32 (34%)