Protein Alignment Cc2d2a and CC2D2A

DIOPT Version :10

• Sequence 1: NP_611229.2
• Gene: Cc2d2a / 36982
• FlyBaseID: FBgn0263113
• Length: 1336
• Species: Drosophila melanogaster
• Sequence 2: NP_001073991.2
• Gene: CC2D2A / 57545
• HGNCID: 29253
• Length: 1620
• Species: Homo sapiens
• Alignment Length: 1624
• Identity: 391/1624 - (24%)
• Similarity: 654/1624 - (40%)
• Gaps: 406/1624 - (25%)

  Fly     1 MEAALSRKTAKKKRKTHTTRGYR-----KREQEVQ------KLIRATEGRISGPEHDMEALSLQF 54
            ::||.|:..:...::..|.|..|     |:|.|.:      |.:..|:     .|.|.::.|...
Human   108 LQAARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQ-----QEVDSQSYSRVK 167

  Fly    55 FH--------------GF----------------EGEMQQENDFAVEDCQESDEDSGGELAEEPT 89
            ||              ||                |.|..:|...|......:.|:..||..|.|.
Human   168 FHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPA 232

  Fly    90 DSPSQTFIHIDLHDPPLAWGQLFKQRHYYDESLLYRPSN--TLHFQLHLSDLSELKDSQIRMLNR 152
            ....:.....:|.:...|...|....|..|:.:..||::  ::|.:|.:         :..||..
Human   233 QGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQM---------EREMLFI 288

  Fly   153 YQEQSKSKSGKLGSDLIGQLSGQKPASFLMGKHLYRSV---CHRRFQSVF--------------- 199
            ...|:.....||..::       :| .||..:.||..|   ..|..|::.
Human   289 PSRQTVPTYKKLPENV-------QP-RFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFG 345

  Fly   200 --------------FPPMPP---------SELKGL--------------------PSRRCLKLCL 221
                          ||..||         :||:.|                    |....|.:.:
Human   346 DDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDI 410

  Fly   222 KQLRFSLHPQLLEEHRLAQQLEDLFDVYSQQRKQRICRKLREELEIARQVALKLLASAGQDQTA- 285
            ..|.|:.||....||.||.:|..|:|.|..:.::...:.|.::|:     ||:.....|.|...
Human   411 SGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQ-----ALRNAVQTGLDPEKP 470

  Fly   286 ------------EVKRQLKLTRQLRQRYYAESAAQRNLLQRLLKEWAKLKELRRQQRFQCTRFQL 338
                        |.|.:::.||:.|.   ||....|.||:.::|.|.::|.||..|||..|..:|
Human   471 HQSLDTIQKTINEYKSEIRQTRKFRD---AEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKL 532

  Fly   339 GLRVVHPPDLEASYCAWKESFETDLAEVYREH-------LELFYTRLRLW--------TDQKSHS 388
            .|| ....|.:|...|::...:.:::|:..||       :|.:.|.|:.|        ..:|...
Human   533 VLR-KEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRK 596

  Fly   389 RTATGHS--------------KPPRKPQFDR--IMASLRKEYDKTFKDPEEPYVEVFRLHADEAT 437
            :.|..|.              ||......||  |...:|:...::.:.|.||.:      ..|.:
Human   597 QAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTL------VPELS 655

  Fly   438 ARLSIPGGDQLPKA----------RNYFLKIFLDGQFVGQSRTYRLEPDLQISINECIGVLLERS 492
            ...|:...||.|:|          |:.:||:..:.:.|.::.:..|..|.::...:...:.:. :
Human   656 LAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIV-N 719

  Fly   493 LPENLNIWLYE-----KSTLTPKSRRLAQISTPL----VLSSKDDAVQEKL-------------- 534
            .||:|.:.:||     ..||      ||::..|:    |::.:  |..|::
Human   720 WPESLTLQVYETVGHSSPTL------LAEVFLPIPETTVVTGR--APTEEVEFSSNQHVTLDHEG 776

  Fly   535 -------SFQALSSTQL----AGDVYLYYEYRSTE--------------GWGSALH--------- 565
                   ||:|..|.||    :|.|.....:...|              |:.|||.
Human   777 VGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIG 841

  Fly   566 ---LDDVQRLPDALRQTLL----PQSLPALPQASKELVTPRPPSGRIKKSQLPSLIFAE---QQL 620
               |.|:::|.....::.|    |.:.|.:     :|::. ..||   :|.:|.....|   |:.
Human   842 TSGLTDMKKLAKWAAESKLDPNDPNNAPLM-----QLISV-ATSG---ESYVPDFFRLEQLQQEF 897

  Fly   621 QFCGLDVLLDNRRFQLLHSRHQQ----RNLHTKQLRFVPALEQEISE------EEPLPDGRGTVQ 675
            .|.....|..::||:|||.|.|:    ||.  ||   ||..::||.|      |:.|.| |..::
Human   898 NFVSDQELNRSKRFRLLHLRSQEVPEFRNY--KQ---VPVYDREIMEKVFQDYEKRLRD-RNVIE 956

  Fly   676 LLEPGTYWNPIDLHKHRGRKFLQLLYE------VIASQSARRAKALQTPLPLLLLAEDSDRSSGT 734
            ..|      .||.|:....|:||.:.|      :||.|....|.        :::.|:....|..
Human   957 TKE------HIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLAD--------MIVEEEVPNISIL 1007

  Fly   735 GWTALWRAFCSVFQGQRNSLPREPSGWSGHQ--SAPDLFK-SFCVSLHVVRATGVPVR------- 789
            |        .|:|:......|..|.. .|.:  :|.:|.. ...:.:::|||..:|||
Human  1008 G--------LSLFKLAEQKRPLRPRR-KGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKF 1063

  Fly   790 ---SRHILNLNERRSSAGGDMSTSLFVTQTLMYSNVRPFVTLSYGQRLCRSRTAEGSNPTWNEQL 851
               ||.....:|:.:::....|.:......|....|||||.:|:.:.:|.:.||||.||:|||:|
Human  1064 QQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEEL 1128

  Fly   852 QLQIQSQFGD--------LRDDLKISLFDELIEQQYSDE---ASDVYQRVQCNWLGEFRVPINSL 905
            :|..::..||        ::|.:.|::|||::.....|:   .|.::.|::.:|||..::|.:::
Human  1129 ELPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTI 1193

  Fly   906 LASRTFEGCIELAMPKVLVGY--KRPLI-----DSVTNMPTDQYPEFKEAVHLWFYLSIEPGGGD 963
            ......:|..::.:|.||:||  :|.:|     |||.::        .|..::..:::|||   .
Human  1194 YFQARIDGTFKIDIPPVLLGYSKERNMILERGFDSVRSL--------SEGSYITLFITIEP---Q 1247

  Fly   964 LAPLHSCALACAEKPELQQYLDERRLELQQ------LLPQPQRYVEPLVCTAQGKRVCLTRLMDP 1022
            |.|..|    ..||.|.|:  ||:.|:..:      .|..|.|.....|....||.|.:||.:.|
Human  1248 LVPGES----IREKFESQE--DEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKP 1306

  Fly  1023 VPLPPAAVPSGENPL----EICIRYVSLLSHLRSYDPCQGFRGVWLDNQSLLDSTWCSVKDLGVL 1083
            :..|...:....|.|    |:..|||||:..|.......|...:|..:...||......::..||
Human  1307 LNPPQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVL 1371

  Fly  1084 LCNYMLSLGLECWLILGVSCPHGECSFVLFRQPETAELFLVSPATGKRYQLQDVHCPLRRIYCVV 1148
            ||||.||||.:.||::|.:.|.|..::||  ..|.....:.:|.:|..|...|..|||:.:.|::
Human  1372 LCNYFLSLGKKAWLLMGNAIPEGPTAYVL--TWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLI 1434

  Fly  1149 GKQNIYFNIQTETRVSMTHFNLQDGACWFPLFRRRVPAP-QSGVQKLDYAYKRSYE--LSQLQKH 1210
            |..||:||||........:|::.....|...|.|.:|.| .|.||..:..|:||.:  .::||..
Human  1435 GPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDR 1499

  Fly  1211 IERKIMKKISAWRTTRKTIWN-------RAFQPRLHKILCDMEDLSTFSRGRYDEPIFSEQLERE 1268
            ||:.:.:||..||....|.||       |.|.|.|.|           |:|...|.....:|.::
Human  1500 IEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEK-----------SQGEDVEDDHRAELLKQ 1553

  Fly  1269 FPNYRLYGFTLNFAYTNLAAISERIRTSCIHYNHDASVEFCVAVHLHAHANDVLSVWLFLLSMV 1332
            ..:||..||.|:..|:.:..:.:.:.::.:|.....:|||.:||::|.:..:|||||:::.|::
Human  1554 LGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLI 1617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cc2d2a	NP_611229.2	COG4913	<231..>352	CDD:443941	38/133 (29%)
		CC2D2AN-C2	421..>545	CDD:464780	34/167 (20%)
		C2	<824..917	CDD:425499	31/103 (30%)
CC2D2A	NP_001073991.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..241		27/137 (20%)
		DUF5523	131..383	CDD:465443	50/273 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	592..628		6/35 (17%)
		CC2D2AN-C2	645..819	CDD:464780	37/188 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1062..1087		4/24 (17%)
		DDA1	1066..>1099	CDD:401980	5/32 (16%)
		C2	<1097..>1135	CDD:472691	18/37 (49%)